Study Purpose:
An open-label dose-escalation trial was performed to assess the safety and tolerability of high doses of coenzyme Q10 (CoQ10) in ALS. CoQ10, a cofactor in mitochondrial electron transfer, may improve the mitochondrial dysfunction in ALS. In this study, CoQ10 was safe and well tolerated in 31 subjects treated with doses as high as 3,000 mg/day for 8 months.
Study Status:
Not recruiting
Disease:
Amyotrophic Lateral Sclerosis (ALS) , Familial ALS , Sporadic ALS
Study Type:
Interventional
Type of Intervention:
Drug Trial
Intervention Name:
Placebo:
Phase:
N/A
Study Chair(s)/Principal Investigator(s):
Merit Cudkowicz, Massachusetts General Hospital
Clinicaltrials.gov ID:
Neals Affiliated?
Yes
Coordinating Center Contact Information
Study Sponsor:
Estimated Enrollment:
31
Estimated Study Start Date:
06 / 01 / 2001
Estimated Study Completion Date:
05 / 31 / 2003
Posting Last Modified Date:
05 / 09 / 2019
Date Study Added to neals.org:
05 / 09 / 2019