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With support from The ALS Association, NEALS provides up-to-date information about ALS interventional trials and observational studies.
With support from The ALS Association, NEALS provides up-to-date information about ALS interventional trials and observational studies.
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Trial Name | Study Type | Phase | Status | KEY |
---|---|---|---|---|
Effect of Salbutamol on Walking Capacity in Ambulatory ALS Patients | Interventional | Phase 2 | Not yet recruiting | p_2 os_nye st_int country_France NCT05860244 |
Clinical Characteristics, Natural History, Health Care Measures, and the Frequency of Genetic Variants in the Genes of SOD1, C9orf72, FUS and TARDBP in Patients With Sporadic and Familial Amyotrophic Lateral Sclerosis (ALS) | Observational [Patient Registry] | N/A | Recruiting | os_enr FUS C9orf72 SOD1 otherGenes st_obs country_Germany NCT05852405 |
Registry Study of the Provision of Assistive Devices, Medicines, and Other Healthcare Measures in an Inter-cohort Observation of Patients With ALS , SMA and Other Neurological Diseases. | Observational | N/A | Recruiting | os_enr st_obs country_Germany NCT05852418 |
Contribution of a Multimodal Digital Platform in the Management and Follow-up of Patients With Amyotrophic Lateral Sclerosis Treated With Non-invasive Ventilation: Randomized Controlled Study | Interventional | N/A | Not yet recruiting | p_NA os_nye p_Oint st_int country_France NCT05837507 |
Digital Smartwatch Measurements as Potential Biomarkers for Remote Disease Tracking in ALS (CAPTURE ALS Smarwatch) | Observational | N/A | Not yet recruiting | os_nye os_ahv st_obs state_Alberta country_Canada NCT05830214 |
Ambulatory Versus Inpatient Initiation of Home Non-invasive Mechanical Ventilation in Patient With Amyotrophic Lateral Sclerosis: a Prospective, Noninferiority Randomized Controlled Trial (The NIB-study) | Interventional | N/A | Not yet recruiting | p_NA os_nye st_plc p_Oint st_int NCT05829330 |
Evaluation of the Effect of Respiratory Physiotherapy by Mechanical In-exsufflator on Respiratory Function in Patients With Amyotrophic Lateral Sclerosis: A Pilot Study | Interventional | N/A | Not yet recruiting | p_NA os_nye p_Oint st_int state_Occitanie country_France NCT05819931 |
An Open-label, Randomized, 2-sequence, 2-period, 2-treatment, 2-part Study to Evaluate the Relative Bioavailability of SAR443820 in Tablet Formulation Versus Capsule Formulation in Fasted Condition (Part 1) and the Food-effect on SAR443820 in Tablet Formulation (Part 2) in Healthy Adult Male and Female Participants | Interventional | Phase 1 | Not recruiting | p_1 os_nte os_ahv st_plc p_Oint st_int state_Minnesota country_United States NCT05797701 |
A Phase 1, Single-center, Open-label, 2-part, 2-treatment Period, 1-sequence, Cross-over, Drug-drug Interaction Study to Investigate the Effect of Erythromycin on SAR443820 (Part A) and the Effect of Itraconazole on SAR443820 (Part B) in Healthy Adult Participants | Interventional | Phase 1 | Not recruiting | p_1 os_nte os_ahv p_Oint st_int state_Minnesota country_United States NCT05797753 |
A Randomized, Double-blind, Placebo-controlled Study of the Safety, Tolerability and Pharmacokinetics of Ascending Single and 14-day Repeated Oral Doses of SAR443820 in Healthy Adult Participants. | Interventional | Phase 1 | Not recruiting | p_1 os_nte os_ahv st_plc p_Oint st_int state_Minnesota country_United States NCT05795907 |
Technical Evaluation and Usability Analysis of a Novel Ear-worn Assistive Device | Interventional | N/A | Not yet recruiting | p_NA os_nye os_ahv p_Oint st_int NCT05784727 |
Counterfactual Thinking Assessment in Amyotrophic Lateral Sclerosis | Observational | N/A | Recruiting | os_enr st_obs country_Italy NCT05768646 |
Spinal Cord Gray and White Matter Imaging in Amyotrophic Lateral Sclerosis | Observational | N/A | Recruiting | os_enr st_obs country_Switzerland NCT05764434 |
Open Label Extension Study to Investigate Long Term Safety, Tolerability and Efficacy of Tauroursodeoxycholic Acid in Patients With ALS Who Completed the TUDCA-ALS Study | Interventional | Phase 3 | Recruiting | p_3 os_enr st_wad st_int country_Belgium country_France country_Germany country_Ireland country_Italy country_Netherlands country_United Kingdom NCT05753852 |
Longitudinal Assessment of Autonomic and Sensory Nervous System in ALS | Interventional | N/A | Recruiting | p_NA os_enr p_Oint st_int state_Benevento country_Italy NCT05747937 |
Effects of Long Term Ventilation Support on the Quality of Life of ALS Patients and Their Families | Interventional | N/A | Recruiting | p_NA os_enr os_ahv p_Oint st_int country_Norway NCT05744310 |
Virtual Seating Coach on Power Wheelchairs of Persons With ALS | Interventional | N/A | Not recruiting | p_NA os_nte p_Oint st_int state_North Carolina country_United States NCT05742828 |
Single Neuron Population Dynamics in Human Speech Motor Cortex for a Speech Prosthesis | Interventional | N/A | Recruiting | p_NA os_enr p_Oint st_int state_California country_United States state_Massachusetts NCT05724173 |
The Effects of Rehabilitation on Functional Outcomes in Patients With SOD1 ALS Treated With Tofersen | Interventional | N/A | Recruiting | p_NA os_enr p_Oint SOD1 st_int state_Missouri country_United States NCT05725759 |
The Effect of Low-İntensity Combined Exercises on Fatigue, Balance and Quality of Life in Patients With Early Stage ALS | Interventional | N/A | Recruiting | p_NA os_enr p_Oint st_int state_Bakirkoy country_Turkey NCT05716074 |
Phase 1 Safety Run-in Study and Phase 1b Randomized, Double Blinded, Placebo Controlled Trial | Interventional | Phase 1 | Recruiting | p_1 os_enr st_plc p_Oint st_int state_New York country_United States NCT05695521 REGALS, T Cells |
A Multicenter, Open-label Extension (OLE) Study to Evaluate the Safety, Pharmacodynamics, and Clinical Effects of WVE-004 in Patients With C9orf72-associated Amyotrophic Lateral Sclerosis (ALS) and/or Frontotemporal Dementia (FTD) | Interventional | Phase 1/Phase 2 | Recruiting | p_1 p_2 os_enr st_wad p_Oint C9orf72 st_int country_Netherlands country_United Kingdom NCT05683860 |
Anticipated Patient and Caregiver Burden: Impact in People With Amyotrophic Lateral Sclerosis | Interventional | N/A | Recruiting | p_NA os_enr p_Oint st_int country_France NCT05632757 |
A Multi-Center, Randomized, Double-Blind Placebo Controlled Multiple-Ascending Dose Study to Evaluate the Safety and Tolerability of QRL-201 in Amyotrophic Lateral Sclerosis | Interventional | Phase 1 | Recruiting | p_1 os_enr st_plc p_Oint st_int state_Alberta country_Canada state_Quebec NCT05633459 |
A Phase IIIb, Open Label Extension Study Evaluating The Safety And Tolerability of AMX0035 Up To 108 Weeks In Adult Participants With Amyotrophic Lateral Sclerosis (ALS) Previously Enrolled In Study A35-004 (PHOENIX) | Interventional | Phase 3 | Recruiting | p_3 os_enr st_wad st_int country_Belgium country_France country_Germany country_Ireland country_Italy country_Netherlands country_Poland country_Portugal country_Spain country_Sweden country_United Kingdom NCT05619783 |
Satisfaction of Patients With Amyotrophic Lateral Sclerosis Under Non-invasive Ventilation Regarding Home Assisted Teleconsultation | Interventional | N/A | Not yet recruiting | p_NA os_nye p_Oint st_int country_France NCT05621213 |
A Mindful Community for People With ALS and Their Primary Caregivers | Interventional | N/A | Not yet recruiting | p_NA os_nye p_Oint st_int NCT05595850 |
Factors Associated With Success of Non-invasive Positive Pressure Ventilation in Patients With Amyotrophic Lateral Sclerosis: A Retrospective Cohort Study | Observational | N/A | Not recruiting | os_nte st_obs country_Korea, Republic of NCT05581771 |
Feasibility and Sensitivity of a Symptom Monitoring Application in Real Time (SMART) for ALS | Observational | N/A | Recruiting | os_enr p_Oint st_obs Massachusetts General Hospital state_Massachusetts country_United States NEALS1245 |
Glial Activation Measured by PBR28-PET in People with Neurogenerative Disease | Observational | N/A | Recruiting | os_enr p_Oint st_obs Massachusetts General Hospital state_Massachusetts country_United States NEALS1381 |
Positron Emission Tomography to Characterize in vivo Neuroinflammation in the Spinal Cord in People with ALS | Observational | N/A | Not recruiting | os_nte p_Oint st_obs Massachusetts General Hospital state_Massachusetts country_United States NEALS1244 |
Rasch-built Outcome Measures to Improve ALS Clinical Trials | Observational | N/A | Recruiting | os_enr p_Oint st_obs Emory University state_Georgia country_United States NEALS5844 |
Multicenter, Open-label Extension Study Following the Studies MT-1186-A03 or A04 to Evaluate the Safety of Oral Edaravone in Subjects With Amyotrophic Lateral Sclerosis (ALS) | Interventional | Phase 3 | Recruiting | p_3 os_enr st_wad st_int state_Aichi country_Japan state_Chiba state_Fukushima state_Kagawa state_Kanagawa state_Kumamoto state_Osaka state_Shiga state_Tokyo NCT05568615 |
Plasmapheresis in Amyotrophic Lateral Sclerosis With Autoantibody Against NRIP | Interventional | N/A | Not yet recruiting | p_NA os_nye st_wad p_Oint st_int NCT05562960 |
Prospective Randomized Open, Blinded Endpoint (PROBE) Study of AMDX-2011P as a Retinal Tracer in Subjects With Neurodegenerative Diseases Associated With Amyloidogenic Proteinopathy | Interventional | Phase 1/Phase 2 | Recruiting | p_1 p_2 os_enr st_wad p_Oint TDP-43 st_int state_California country_United States NCT05542576 |
A Double-blind, Placebo-controlled, Exploratory Randomised Clinical Trial to Assess the Safety and Efficacy of IFB-088 Plus Riluzole 100 mg vs Placebo Plus Riluzole 100 mg in Patients With Bulbar-onset Amyotrophic Lateral Sclerosis. | Interventional | Phase 2 | Recruiting | p_2 os_enr st_plc st_int country_France country_Italy NCT05508074 |
Quality of Life Evaluation With the SRI Questionnaire of ALS Patient With Non-invasive Ventilation | Interventional | N/A | Recruiting | p_NA os_enr p_Oint st_int country_France NCT05498883 |
Clinical & Genetic Studies in ALS and Other Neurodegenerative Motor Neuron Disorders | Observational | N/A | Recruiting | os_enr st_obs state_Florida country_United States NCT05474235 |
Enhancement and Optimization of a Mobile iBCI for Veterans With Paralysis | Interventional | N/A | Not yet recruiting | p_NA os_nye st_wad p_Oint st_int state_Rhode Island country_United States NCT05470478 |
A Phase 3, Open-Label Extension of COURAGE-ALS (CY 5031)![]() | Interventional | Phase 3 | Not recruiting | p_3 os_nte st_wad _NAT st_int state_Arizona country_United States state_California state_Colorado state_District of Columbia state_Florida state_Indiana state_Kansas state_Maryland state_Michigan state_Nebraska state_New York state_North Carolina state_Ohio state_Texas state_Virginia state_Wisconsin state_New South Wales country_Australia state_Queensland country_Belgium state_Alberta country_Canada state_New Brunswick state_Ontario state_Quebec state_Saskatchewan country_Ireland country_Italy country_Netherlands country_Spain country_Sweden NCT05442775 |
In Depth Observational Clinical Trial - Analyzing Participation Experiences Of Amyotrophic Lateral Sclerosis Patients | Observational | N/A | Not yet recruiting | os_nye st_obs NCT05423678 |
Stem Cells for Research in Motor Neuron Disease![]() | Observational | N/A | Recruiting | os_enr os_ahv _NAT p_Oint st_obs Massachusetts General Hospital state_Massachusetts country_United States NEALS1131 |
Assessing Activation of Brain Microglia in ALS with Simultaneous MR-PET![]() | Observational | N/A | Not recruiting | os_nte _NAT p_Oint st_obs Massachusetts General Hospital state_Massachusetts country_United States NEALS1130 |
Evaluation of microglial activation using the PET imaging ligand [18F]PBR06 in patients with amyotrophic lateral sclerosis compared to healthy volunteers | Interventional | Phase 1 | Not recruiting | p_1 os_nte p_Oint st_int Institute for Neurodegenerative Disorders state_Connecticut country_United States NEALS1221 |
Genomic Translation for Amyotrophic Lateral Sclerosis Care![]() | Observational | N/A | Not recruiting | os_nte _NAT p_Oint st_obs Columbia University state_New York country_United States state_California state_Colorado state_Michigan state_Minnesota state_Missouri state_North Carolina state_Oregon state_Pennsylvania state_Texas state_Utah state_Washington country_United Kingdom NCT02795897 |
The Natural History of SOD1 Amyotrophic Lateral Sclerosis![]() | Observational | N/A | Not recruiting | os_nte _NAT p_Oint st_obs Washington University in St. Louis state_Missouri country_United States NEALS1151 |
Longitudinal Study Comparing the Responsiveness of Outcomes Measures in ALS Trials![]() | Observational | N/A | Not recruiting | os_nte _NAT p_Oint st_obs Massachusetts General Hospital state_Massachusetts country_United States state_California state_Kentucky state_Missouri state_Pennsylvania NEALS1146 |
Microbiome Assessment in People with ALS (MAP ALS)![]() | Observational | N/A | Not recruiting | os_nte _NAT p_Oint st_obs Massachusetts General Hospital state_Massachusetts country_United States NEALS1206 |
Cross-Sectional ALS Biofluid Biomarker (CABB) Study![]() | Observational | N/A | Not recruiting | os_nte _NAT p_Oint st_obs Massachusetts General Hospital (NCRI) state_Massachusetts country_United States state_Connecticut state_District of Columbia state_Kentucky state_Maryland state_Missouri state_New Hampshire state_North Carolina state_Oregon state_Pennsylvania state_Tennessee state_Washington state_Wisconsin NEALS1205 |
Answer ALS: Individualized Initiative for ALS Discovery![]() | Observational | N/A | Not recruiting | os_nte _NAT p_Oint st_obs Massachusetts General Hospital state_Massachusetts country_United States state_California state_Georgia state_Illinois state_Maryland state_Missouri state_Ohio state_Texas NCT02574390 |
Phenotype, Genotype & Biomarkers in ALS and Related Disorders | Observational | N/A | Not recruiting | os_nte p_Oint st_obs University of Miami state_Florida country_United States state_California state_Iowa state_Kansas state_Minnesota state_North Carolina state_Ohio state_Pennsylvania state_Texas state_Virginia country_Germany country_South Africa NCT02327845 |
Analysis of Immune Activation in the Peripheral Blood of Patients with ALS![]() | Observational | N/A | Not recruiting | os_nte _NAT p_Oint st_obs Massachusetts General Hospital state_Massachusetts country_United States NEALS1133 |
Multicenter PLS Cohort Study of Oxidative Stress and Disease Progression | Observational | N/A | Not recruiting | os_nte p_Oint st_obs The Eleanor and Lou Gehrig MDA/ALS Research Center state_New York country_United States state_Kansas state_Kentucky state_Texas state_Ontario country_Canada NEALS1126 |
Magnetic Resonance Spectroscopy in Amyotrophic Lateral Sclerosis![]() | Observational | N/A | Not recruiting | os_nte _NAT p_Oint st_obs Neurological Clinical Research Institute at Massachusetts General Hospital state_Massachusetts country_United States NEALS1123 |
Coping Effectiveness Training for Recently Diagnosed ALS Patients and Care Partners | Interventional | N/A | Not recruiting | p_NA os_nte p_Oint st_int New York State Psychiatric Institute, Columbia University Medical Center state_New York country_United States NCT01583205 |
Effectiveness Trial of Detailed NIPPV Feedback to Patients | Interventional | Phase 3 | Not recruiting | p_3 os_nte st_int University of Pittsburgh state_Pennsylvania country_United States NCT01035476 |
Measuring self-reported fatigue in people with ALS and healthy volunteers | Observational | N/A | Not recruiting | os_nte p_Oint st_obs Sean M. Healey and AMG Center for ALS at Massachusetts General Hospital (MGH) state_Massachusetts country_United States NEALS5738 |
Safety Study of Oral Edaravone Administered in Subjects With ALS | Interventional | Phase 3 | Not recruiting | p_3 os_nte st_wad st_int state_Arizona country_United States state_Arkansas state_California state_Colorado state_Florida state_Georgia state_Massachusetts state_Michigan state_Minnesota state_Nebraska state_North Carolina state_Pennsylvania state_Tennessee state_Texas state_Washington state_Wisconsin state_Alberta country_Canada state_Quebec state_Alpes Maritimes country_France state_Marcland state_Piemonte country_Italy NCT04165824 |
TRIAL READY (Clinical Trial Readiness) | Observational | N/A | Not recruiting | os_nte p_Oint st_obs University of Miami state_Florida country_United States state_Kansas state_Pennsylvania NCT03912987 |
Non-invasive Brain Stimulation for the Treatment of Depression Symptoms in ALS: A Pilot Study | Interventional | N/A | Not recruiting | p_NA os_nte p_Oint st_int Hospital for Special Surgery state_New York country_United States NCT03373981 |
A randomized, placebo-controlled trial of topiramate in amyotrophic lateral sclerosis![]() | Interventional | N/A | Not recruiting | os_nte _NAT st_int NEALS5595 |
A Clinical Trial of Creatine in ALS![]() | Interventional | N/A | Not recruiting | os_nte _NAT st_int NEALS5594 |
Tolerance of high-dose coenzyme Q10 in ALS![]() | Interventional | N/A | Not recruiting | os_nte _NAT st_int NEALS5593 |
Trial of Celecoxib in Amyotrophic Lateral Sclerosis![]() | Interventional | N/A | Not recruiting | os_nte _NAT st_int NEALS5592 |
Generation and characterization of cell lines for amyotrophic lateral sclerosis![]() | Observational | N/A | Not recruiting | os_nte _NAT p_Oint st_obs Johns Hopkins University state_Maryland country_United States NEALS5591 |
Clinical Procedures to Support Research in ALS (CAPTURE-ALS) | Observational | N/A | Recruiting | os_enr p_Oint st_obs University of Miami state_Florida country_United States state_California state_Colorado state_Kansas state_Minnesota state_New York state_North Carolina state_Oregon state_Texas NCT03489278 |
The DIALS (Dominant Inherited ALS) Network![]() | Observational | N/A | Recruiting | os_enr _NAT p_Oint st_obs Massachusetts General Hospital; NCRI state_Massachusetts country_United States state_Missouri NEALS1330 |
Genetic Characterization of Movement Disorders and Dementias | Observational | N/A | Recruiting | os_enr os_ahv p_Oint st_obs National Institute of Aging country_United States state_Maryland NCT02014246 |
Cognition, Behavior and Caregiver Burden in Amyotrophic Lateral Sclerosis | Observational | N/A | Not recruiting | os_nte p_Oint st_obs VA Boston Healthcare System state_Massachusetts country_United States NEALS1335 |
Expanded Access Use of microRNA Delivered Intrathecally via Adeno-Associated Virus rh10 as Therapy for Mutant SOD1 Mediated Amyotrophic Lateral Sclerosis (ALS)![]() | Interventional | Phase 1 | Not recruiting | p_1 os_nte st_wad _NAT p_Oint st_int Massachusetts General Hospital state_Massachusetts country_United States NEALS1331 |
A Randomized, Double-Blind, Controlled, Parallel Group Study to Evaluate the Efficacy and Safety of FLX-787-ODT for Treatment of Muscle Cramps in Adult Subjects With Motor Neuron Disease | Interventional | Phase 2 | Not recruiting | p_2 os_nte st_plc st_int state_Arizona country_United States state_California state_Colorado state_Connecticut state_District of Columbia state_Florida state_Indiana state_Kansas state_Maryland state_Missouri state_New York state_North Carolina state_Oregon state_Pennsylvania state_Texas state_Utah state_Vermont state_Washington state_Wisconsin NCT03196375 |
Longitudinal Assessment of the Gut Microbiome in People with ALS | Observational | N/A | Recruiting | os_enr os_ahv p_Oint st_obs Sean M. Healey & AMG Center for ALS at Massachusetts General Hospital state_Massachusetts country_United States NEALS5832 |
PLS Natural History Study (PNHS) | Observational | N/A | Recruiting | os_enr p_Oint st_obs Columbia University state_New York country_United States state_California state_Florida state_Georgia state_Illinois state_Kansas state_Kentucky state_Maryland state_Massachusetts state_Michigan state_Minnesota state_Missouri state_Nebraska state_Ohio state_Pennsylvania state_Texas state_Virginia state_Alberta country_Canada state_Ontario state_Quebec state_Toronto NEALS5827 |
Home-based Remote Digital Monitoring to Assess ALS progression (Track-ALS)![]() | Observational | N/A | Recruiting | os_enr _NAT p_Oint st_obs Barrow Neurological Institute state_Arizona country_United States state_Georgia NEALS5826 Track-ALS |
PATHOGENESIS IN C9ORF72-RELATED ALS (PiCALS) | Observational | N/A | Recruiting | os_enr os_ahv p_Oint st_obs Emory ALS Center state_Georgia country_United States NEALS5814 |
ALS Sample Repository (Living Library) | Observational | N/A | Recruiting | os_enr os_ahv p_Oint st_obs Massachusetts General Hospital state_Massachusetts country_United States NEALS5788 |
A Longitudinal Analysis of Biomarkers in Patients with ALS | Observational | N/A | Recruiting | os_enr os_ahv p_Oint st_obs Massachusetts General Hospital state_Massachusetts country_United States NEALS5787 |
Microbiome in the Progression of ALS (MPALS) | Observational | N/A | Not recruiting | os_nte p_Oint st_obs Emory ALS Center state_Georgia country_United States NEALS5784 |
ECoG for Motor and Speech Control (BRAVO) | Interventional | N/A | Recruiting | p_NA os_enr p_Oint st_int University of California, San Francisco state_California country_United States NCT03698149 |
Phenotype, Genotype and Biomarkers 2 | Observational | N/A | Recruiting | os_enr os_ahv p_Oint st_obs University of Miami state_Florida country_United States state_Kansas state_Pennsylvania country_South Africa NCT04875416 |
Survey of communication methods, interventions, and participation for people with ALS | Observational | N/A | Not recruiting | os_nte p_Oint st_obs Oregon Health & Science University state_Oregon country_United States NEALS5772 |
A Single or Multiple Visit Protocol for Collection of DNA/RNA/Serum/Plasma/CSF in Amyotrophic Lateral Sclerosis and related disorders | Observational | N/A | Recruiting | os_enr p_Oint st_obs PrecisionMed state_California country_United States state_Missouri state_Oregon state_Texas NEALS5765 |
Smartphone Application to Track the Progression of ALS and Related Motor Neuron Diseases | Observational | N/A | Recruiting | os_enr p_Oint st_obs Johns Hopkins University state_Maryland country_United States NEALS5759 |
Brain-Computer Interface Implant for Severe Communication Disability | Interventional | N/A | Recruiting | p_NA os_enr p_Oint st_int Johns Hopkins Hospital state_Maryland country_United States NCT04576650 |
Psychological Management by Meditation of Full COnscience in Virtual REality of People With Amyotrophic Lateral Sclerosis: Effects on Cognition, Behavior, Quality of Life and Psychological Well-being | Interventional | N/A | Not yet recruiting | p_NA os_nye p_Oint st_int NCT05409508 |
An Prospective Study in a Cohort of Amyotrophic Lateral Sclerosis (ALS) Patients Participating in a Phase IIb Drug Study (NCT05357950) to Evaluate the Correlation Between Oculometric Measurements and ALS Functional Rating Scale (ALSFRS-R) | Observational | N/A | Recruiting | os_enr st_obs country_Israel NCT05407428 |
A Phase 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study Evaluating Safety and Efficacy of CORT113176 (Dazucorilant) in Patients With Amyotrophic Lateral Sclerosis (DAZALS) | Interventional | Phase 2 | Recruiting | p_2 os_enr st_plc st_int country_Belgium country_France country_Netherlands country_Poland NCT05407324 |
Study of Structural and Functional Brain Connectivity Changes in ALS (CoALS-II) | Observational | N/A | Recruiting | os_enr st_obs state_New Hampshire country_United States NCT05404867 |
A Phase 1/2 Study to Evaluate the Safety, Pharmacokinetics and Biodistribution of an Imaging Agent, 18F-OP-801 (18F Hydroxyl Dendrimer), After Intravenous Administration to Patients With Amyotrophic Lateral Sclerosis (ALS) and Healthy Volunteers (HV) | Interventional | Phase 1/Phase 2 | Recruiting | p_1 p_2 os_enr st_wad p_Oint st_int state_California country_United States NCT05395624 |
Control Cohort CTRL COH | Interventional | N/A | Not yet recruiting | p_NA os_nye st_wad p_Oint st_int country_France NCT05370079 |
A Phase IIb, Randomized, Multi-Center, Multinational, Prospective, Double-Blind, Placebo-Controlled Study, With an Open Label Extension, to Evaluate Safety, Tolerability and Efficacy of PrimeC in Subjects With ALS | Interventional | Phase 2 | Recruiting | p_2 os_enr st_plc st_int country_Israel NCT05357950 |
Stratification of Presymptomatic Amyotrophic Lateral Sclerosis: the Development of Novel Imaging Biomarkers | Interventional | N/A | Not yet recruiting | p_NA os_nye st_wad p_Oint st_int NCT05358431 |
Investigating the Genetic Basis of Hereditary Spastic Paraplegia | Observational [Patient Registry] | N/A | Recruiting | os_enr st_obs state_Massachusetts country_United States NCT05354622 |
Contribution of Diaphragmatic Ultrasound for Monitoring Diaphragmatic Function in Patients With Amyotrophic Lateral Sclerosis | Observational | N/A | Not yet recruiting | os_nye st_obs country_France NCT05352958 |
A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Parallel Study to Assess the Efficacy, Safety, Tolerability, PK, and Biomarker Effects of PTC857 in Adult Subjects With Amyotrophic Lateral Sclerosis (CARDINALS)![]() | Interventional | Phase 2 | Recruiting | p_2 os_enr st_plc _NAT st_int state_California country_United States state_Florida state_Georgia state_Kansas state_Michigan state_Nebraska state_Pennsylvania state_Texas state_Queensland country_Australia state_Victoria country_France country_Poland country_Spain NCT05349721 |
Metabotropic Glutamate Receptor 5 Imaging in Amyotrophic Lateral Sclerosis Using Positron Emission Tomography | Interventional | N/A | Recruiting | p_NA os_enr p_Oint st_int country_Switzerland NCT05340660 |
Dysphagia, Quality of Life and Attitudes Towards Percutaneous Endoscopic Gastrostomy in Patients With Amyotrophic Lateral Sclerosis | Observational | N/A | Not yet recruiting | os_nye st_obs country_Slovenia NCT05336760 |
Volume Targeted Versus Pressure Targeted Non-invasive Ventilation in Amyotrophic Lateral Sclerosis: a Randomised Control Trial. | Interventional | N/A | Recruiting | p_NA os_enr p_Oint st_int state_West Midlands country_United Kingdom NCT05328492 |
Exploring the Electro-mechanical Coupling of Fasciculations in Motor Neuron Disease Using Surface Electromyography and Ultrasound: a Feasibility Study | Interventional | N/A | Not recruiting | p_NA os_nte p_Oint st_int country_United Kingdom NCT05314348 |
A Longitudinal Analysis of Biomarkers in Patients With ALS | Observational | N/A | Recruiting | os_enr st_obs state_Florida country_United States NCT05309408 |
Human Neural Progenitor Cells Secreting Glial Cell Line-Derived Neurotrophic Factor (CNS10-NPC-GDNF) Delivered to the Motor Cortex for the Treatment of Amyotrophic Lateral Sclerosis | Interventional | Phase 1 | Recruiting | p_1 os_enr st_wad p_Oint st_int Cedars-Sinai Medical Center state_California country_United States NCT05306457 stem cell |
Optimising the Management of Ventilated Patients and Quality of Life in Motor Neurone Disease: a Pilot Study | Interventional | N/A | Not yet recruiting | p_NA os_nye st_wad p_Oint st_int NCT05299372 |
An Open-Label Extension for the Phase 2, Randomised, Double-Blind, Placebo-Controlled Study in Early Symptomatic Amyotrophic Lateral Sclerosis Patients on Stable Background Therapy to Assess Bioenergetic Catalysis With CNM-Au8 to Slow Disease Progression in ALS | Interventional | Phase 2 | Not recruiting | p_2 os_nte st_int state_New South Wales country_Australia NCT05299658 |
Evaluation of the Early Use of the Pressure Relaxer in the Respiratory Impairment of Patients With Amyotrophic Lateral Sclerosis: Multicenter Randomized Controlled Study. | Interventional | N/A | Not yet recruiting | p_NA os_nye p_Oint st_int NCT05297487 |
An Assistive Powered Wheelchair: Stage 2 Trial - Powered Wheelchair User Evaluation of an Obstacle Alerting System. A Non-interventional Study | Observational | N/A | Not recruiting | os_nte st_obs state_Kent country_United Kingdom NCT05292690 |
A Phase 1, Randomized, Double-Blind, Placebo-Controlled, Dose-Escalating Study to Evaluate the Safety and Pharmacokinetics of Single Ascending and Multiple Doses of Prosetin in Healthy Volunteers | Interventional | Phase 1 | Recruiting | p_1 os_enr st_plc p_Oint st_int country_United States state_Texas NCT05279755 |
Home-based Remote Digital Monitoring to Assess ALS Progression (Track ALS) | Observational | N/A | Recruiting | os_enr st_obs state_Arizona country_United States state_Georgia NCT05276349 |
A Phase 2, Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of SAR443820 in Adult Participants With Amyotrophic Lateral Sclerosis, Followed by an Open-label Extension![]() | Interventional | Phase 2 | Recruiting | p_2 os_enr st_plc _NAT st_int Sanofi state_Arizona country_United States state_California state_Colorado state_District of Columbia state_Florida state_Illinois state_Maryland state_Massachusetts state_New York state_Pennsylvania state_Utah state_Wisconsin country_Belgium state_Alberta country_Canada state_Ontario state_Quebec country_China country_France country_Germany country_Italy state_Aichi country_Japan state_Chiba state_Tokushima state_Tokyo country_Netherlands country_Poland state_Barcelona [Barcelona] country_Spain state_Catalunya [Cataluña] country_Sweden state_Devon country_United Kingdom state_Staffordshire NCT05237284 HIMALAYA |
A Phase 2a Open-Label Preliminary Safety, Efficacy, and Biomarker Study of WP-0512 in Patients With Amyotrophic Lateral Sclerosis (ALS) | Interventional | Phase 2 | Not recruiting | p_2 os_nte st_wad st_int Woolsey Pharmaceuticals country_United States state_Arizona state_Colorado state_Florida state_Illinois state_Kentucky state_Missouri state_New York state_New South Wales country_Australia state_Queensland state_Victoria NCT05218668 |
Cultivating Self-Compassion Course for Persons Living With Amyotrophic Lateral Sclerosis | Observational | N/A | Not recruiting | os_nte p_Oint st_obs Washington University School of Medicine state_Missouri country_United States NCT05202743 |
Randomised Double-Blind Placebo-Controlled Phase 3 Trial of Triumeq in Amyotrophic Lateral Sclerosis | Interventional | Phase 3 | Recruiting | p_3 os_enr st_plc st_int state_New South Wales country_Australia state_Queensland state_South Australia state_Tasmania state_Victoria state_Western Australia NCT05193994 |
Neurodegenerative Alzheimer's Disease and Amyotrophic Lateral Sclerosis (NADALS) Basket Proof of Concept Trial Including Asymptomatic Individuals Using Baricitinib | Interventional | Phase 1/Phase 2 | Recruiting | p_1 p_2 os_enr st_wad p_Oint st_int state_Massachusetts country_United States NCT05189106 |
Non-invasive Brain-computer Interfaces for Control of Assistive Devices | Interventional | N/A | Recruiting | p_NA os_enr p_Oint st_int The University of Texas at Austin state_Texas country_United States NCT05183152 |
A Multicenter, Randomized, Double-blind, Placebo-controlled Study to Investigate the Efficacy and Safety of FAB122 in Patients With Amyotrophic Lateral Sclerosis | Interventional | Phase 3 | Not recruiting | p_3 os_nte st_plc st_int country_Belgium country_France country_Germany country_Ireland country_Italy country_Netherlands country_Poland country_Portugal country_Spain country_Sweden country_United Kingdom NCT05178810 |
A 6-Month Extension Study Following Protocol VMALS-002-2 (A Phase 2a, Double-Blind, Randomized, Placebo-Controlled, Multicenter Study to Assess the Safety of Engensis in Participants With Amyotrophic Lateral Sclerosis) | Interventional | Phase 2 | Not recruiting | p_2 os_nte st_plc st_int country_United States state_Texas country_Korea, Republic of NCT05176093 |
A Phase IIa Trial to Evaluate the Safety, Tolerability, and Biological Activity of LAM-002A (Apilimod Dimesylate Capsules) in C9ORF72-Associated Amyotrophic Lateral Sclerosis![]() | Interventional | Phase 2 | Not recruiting | p_2 os_nte st_plc _NAT C9orf72 st_int country_United States state_Iowa state_Maryland state_Massachusetts NCT05163886 |
A Phase 3b, Multicenter, Randomized, Double-blind Extension Study to Evaluate the Continued Efficacy and Safety of Oral Edaravone Administered for an Additional Period of up to 48 Weeks Following Study MT-1186-A02 in Subjects With Amyotrophic Lateral Sclerosis (ALS) | Interventional | Phase 3 | Recruiting | p_3 os_enr st_plc st_int state_Arkansas country_United States state_Florida state_Georgia state_Illinois state_Maryland state_Nebraska state_Pennsylvania state_Texas state_Washington state_West Virginia state_Alberta country_Canada state_Ontario state_Quebec country_Germany state_Aichi country_Japan state_Chiba state_Fukuoka state_Fukushima state_Hiroshima state_Ishikawa state_Kagawa state_Kanagawa state_Kumamoto state_Kyoto state_Miyagi state_Niigata state_Osaka state_Shizuoka state_Tokyo state_Seongdong-gu country_Korea, Republic of country_Switzerland NCT05151471 |
Investigation of the Use of 1 Minute Sit to Stand Test to Evaluate Physical Capacity and Effort-Related Desaturation in Individuals With Amyotrophic Lateral Sclerosis | Observational | N/A | Not yet recruiting | os_nye st_obs country_Turkey NCT05151211 |
Target ALS Biomarker Study; Longitudinal Biofluids, Clinical Measures, and At - Home Measures | Observational [Patient Registry] | N/A | Recruiting | os_enr p_Oint st_obs country_United States state_Arizona state_California state_District of Columbia state_Florida state_Missouri state_New York state_Pennsylvania NCT05137665 |
A Multi-centre Randomised Controlled Trial of Polysomnographic Titration of Non-invasive Ventilation in Motor Neurone Disease (PSG4NIVinMND; 3, Three Letter Acronyms [3TLA]) | Interventional | N/A | Recruiting | p_NA os_enr p_Oint st_int country_Australia NCT05136222 |
Genetisk Studie av Amyotrofisk Lateral Sklerose (ALS) | Observational [Patient Registry] | N/A | Recruiting | os_enr st_obs country_Norway NCT05119387 |
Biospecimen Biorepository for the Study of ALS, ALS-FTD and Similar Neurodegenerative Disorders | Observational [Patient Registry] | N/A | Recruiting | os_enr p_Oint st_obs Mayo Clinic in Florida state_Florida country_United States NCT05116943 |
Cell Signaling, Reinnervation and Metabolism in Kennedy Disease and Amyotrophic Lateral Sclerosis (ALS) | Interventional | N/A | Not yet recruiting | p_NA os_nye st_wad p_Oint st_int country_France NCT05107349 CERMALS |
Intermuscular Coherence: A Biomarker for Early Diagnosis and Follow-up of ALS | Observational | N/A | Recruiting | os_enr p_Oint st_obs University of Chicago country_United States state_California state_Massachusetts state_Missouri NCT05104710 |
Tideglusib for the Treatment of Amyotrophic Lateral Sclerosis (TIDALS): a Randomized Placebo-controlled Phase II Trial | Interventional | Phase 2 | Not yet recruiting | p_2 os_nye st_plc st_int country_Switzerland NCT05105958 |
Home-Based Spirometry Through Telemedicine in Amyotrophic Lateral Sclerosis (ALS) | Observational | N/A | Recruiting | os_enr st_obs state_New York country_United States state_North Carolina NCT05106569 |
A Randomized Placebo-controlled Trial of Nicotinamide/Pterostilbene Supplement in ALS: The NO-ALS Study. Extension Protocol | Interventional | N/A | Recruiting | p_NA os_enr p_Oint st_int country_Norway NCT05095571 |
Contribution of the Neurofilament Assay for the Diagnosis of ALS (Amyotrophic Lateral Sclerosis) in Situations of Diagnostic Standoff After Evaluation in an Expert ALS Center | Observational | N/A | Not yet recruiting | os_nye st_obs NCT05077696 |
Analysis of Human ALS Tissues and Registry of ALS Patients | Observational [Patient Registry] | N/A | Recruiting | os_enr p_Oint st_obs University of Illinois at Chicago state_Illinois country_United States NCT05067179 |
A Phase 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AL001 in C9orf72-Associated Amyotrophic Lateral Sclerosis![]() | Interventional | Phase 2 | Not recruiting | p_2 os_nte st_plc _NAT C9orf72 st_int country_United States state_Arizona state_California state_Colorado state_Florida state_Indiana state_Maryland state_Massachusetts state_Michigan state_Missouri state_Pennsylvania state_Washington NCT05053035 |
A Phase 2a, Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate Safety, Tolerability, Pharmacodynamic Markers, and Pharmacokinetics of AP-101 in Patients With Familial Amyotrophic Lateral Sclerosis (fALS) and Sporadic Amyotrophic Lateral Sclerosis (sALS)![]() | Interventional | Phase 2 | Recruiting | p_2 os_enr st_plc _NAT st_int Montreal Neurological Institute and Hospital country_Canada state_California country_United States state_Alberta state_Ontario state_Quebec country_Germany country_Korea, Republic of country_Sweden NCT05039099 |
A Phase 2 Open Label Trial of 3K3A-APC in Amyotrophic Lateral Sclerosis | Interventional | Phase 2 | Not recruiting | p_2 os_nte st_wad st_int state_New South Wales country_Australia NCT05039268 |
Optimizing INITIation of Non-invasive Ventilation in ALS Patients | Observational [Patient Registry] | N/A | Not yet recruiting | os_nye st_obs NCT05033951 |
Nuclear Factor Kappa Beta Inhibition in Patients With Amyotrophic Lateral Sclerosis: A Phase II Randomized Placebo Controlled Trial | Interventional | Phase 2 | Recruiting | p_2 os_enr st_plc st_int state_Ontario country_Canada NCT05031351 |
A Phase III, Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial to Evaluate the Safety and Efficacy of AMX0035 Versus Placebo for 48-week Treatment of Adult Patients With Amyotrophic Lateral Sclerosis (ALS)![]() | Interventional | Phase 3 | Not recruiting | p_3 os_nte st_plc _NAT st_int country_United States state_Arizona state_California state_Colorado state_Florida state_Georgia state_Illinois state_Maryland state_Massachusetts state_Minnesota state_Missouri state_Nebraska state_New Jersey state_New York state_North Carolina state_Ohio state_Pennsylvania state_Texas state_Virginia state_Washington country_Belgium country_France country_Germany country_Ireland country_Italy country_Netherlands country_Poland country_Portugal country_Spain country_Sweden country_United Kingdom NCT05021536 |
Olfactory Deficits in Neurologic Disease | Observational | N/A | Not recruiting | os_nte st_obs state_Massachusetts country_United States NCT05019014 |
A Phase 1b, Multicenter, Randomized, Placebo-Controlled, Double-Blind Study, Followed by an Open-Label Extension, to Determine the Safety, Pharmacokinetics, and Pharmacodynamics of DNL343 in Participants With Amyotrophic Lateral Sclerosis | Interventional | Phase 1 | Not recruiting | p_1 os_nte st_plc p_Oint st_int Centre for Human Drug Research (CHDR) country_Netherlands state_Arizona country_United States state_California state_Florida state_Georgia state_North Carolina state_South Holland NCT05006352 |
Safety of Cultured Allogeneic Adult Umbilical Cord Derived Mesenchymal Stem Cell Intrathecal Injection for the Treatment of Amyotrophic Lateral Sclerosis | Interventional | Phase 1 | Not recruiting | p_1 os_nte st_wad p_Oint st_int country_Antigua and Barbuda NCT05003921 |
Effectiveness of Expiratory Muscle Strength Training for Improving Communication in ALS | Interventional | N/A | Not recruiting | p_NA os_nte p_Oint st_int Purdue University state_Indiana country_United States NCT05003167 |
EMERALD TRIAL Open-Label Extension Study (EMERALD OLE) | Interventional | Phase 4 | Not recruiting | p_4 os_nte st_wad p_Oint st_int state_Queensland country_Australia NCT04997954 |
A Phase 1/2 Two-center, Double-blind, Randomized, Placebo-controlled Multi-period Crossover (N-of-1) Study to Evaluable the Feasibility, Safety, and Efficacy of TJ-68 in Patients With Amyotrophic Lateral Sclerosis (ALS) and Muscle Cramps | Interventional | Phase 1/Phase 2 | Recruiting | p_1 p_2 os_enr st_plc p_Oint st_int state_Florida country_United States state_New York NCT04998305 |
A Phase 2a Study of TPN-101 in Patients With Amyotrophic Lateral Sclerosis (ALS) and/or Frontotemporal Dementia (FTD) Associated With Hexanucleotide Repeat Expansion in the C9orf72 Gene (C9ORF72 ALS/FTD)![]() | Interventional | Phase 2 | Not recruiting | p_2 os_nte st_plc _NAT C9orf72 st_int country_United States state_California state_Maryland state_Massachusetts state_Minnesota state_New York state_North Carolina state_Flemish Brabankt country_Belgium country_France state_Baden-Wuerttemberg country_Germany state_A Coruña country_Spain NCT04993755 |
A Pharmacokinetic and Pharmacodynamic Study of AMX0035 in Patients With ALS | Interventional | Phase 1/Phase 2 | Not recruiting | p_1 p_2 os_nte st_wad p_Oint st_int country_United States state_Florida NCT04987671 |
Multimodal Brain Imaging Study of Language Cognitive Function in Patients With Amyotrophic Lateral Sclerosis | Observational | N/A | Not recruiting | os_nte st_obs country_China NCT04960540 |
A Study on the Biomarkers of Motor Neuron Disease/Frontal Dementia Spectrum Disease in China | Observational | N/A | Recruiting | os_enr st_obs state_Beijing country_China NCT04961450 |
Application of Motor Unit Estimation Index in Amyotrophic Lateral Sclerosis and Related Diseases | Observational | N/A | Recruiting | os_enr st_obs country_China NCT04956822 |
Home Care Needs and Current Nursing Status of Patients With Amyotrophic Lateral Sclerosis | Observational | N/A | Recruiting | os_enr st_obs country_China NCT04953481 |
Detection of Appetite and Analysis of Related Factors in Patients With Amyotrophic Lateral Sclerosis (ALS) | Observational | N/A | Recruiting | os_enr st_obs state_Beijing country_China NCT04953624 |
Pleiotropy and Mechanism of Peripheral Nerve Related Genes in the Progression of Amyotrophic Lateral Sclerosis | Observational | N/A | Not yet recruiting | os_nye st_obs state_Beijing country_China NCT04953494 |
Effect of Sleep Disorder on Onset and Progression of Amyotrophic Lateral Sclerosis | Observational | N/A | Recruiting | os_enr st_obs state_Beijing country_China NCT04952038 |
A Single-center, Open-label Clinical Study to Evaluate the Efficacy and Safety of Low-dose IL-2 in the Treatment of Immune-associated ALS Syndrome | Interventional | Phase 2 | Recruiting | p_2 os_enr st_wad st_int state_Beijing country_China NCT04952155 |
Tear Fluid and Ocular Surface Metabolomics and Lipidomics in Lateral Amyotrophic Sclerosis: a Prospective Comparative Study | Interventional | N/A | Recruiting | p_NA os_enr p_Oint st_int country_France NCT04953286 |
Brain Imaging Study of Amyotrophic Lateral Sclerosis Based on Accurate Brain Volume Quantitative Analysis | Observational | N/A | Not recruiting | os_nte st_obs state_Beijing country_China NCT04952025 |
Efficacy and Safety of Nitrazine in the Treatment of Amyotrophic Lateral Sclerosis: a Multicenter, Randomized, Double-blind, Placebo-controlled Clinical Study | Interventional | Phase 2 | Recruiting | p_2 os_enr st_plc st_int state_Beijing country_China NCT04950647 |
A Multi-center, Randomized, Double-blind, Positives Parallel Controlled, Phase Ⅱ Clinical Trial to Evaluate the Efficacy and Safety of Huollingshengji Granules in the Treatment of Amyotrophic Lateral Sclerosis (Spleen qi Deficiency, Kidney Yang Deficiency Syndrome) | Interventional | Phase 2/Phase 3 | Recruiting | p_2 p_3 os_enr st_wad st_int country_China NCT04950933 |
Investigation on the Knowledge Needs of ALS Patients and Their Caregivers at Home | Observational | N/A | Not recruiting | os_nte st_obs country_China NCT04950231 |
A Randomized, Double-Blind, Placebo-Controlled Study to Assess Safety, Tolerability, and Pharmacokinetics Following Multiple Doses of ABBV-CLS-7262 in Subjects With Amyotrophic Lateral Sclerosis Followed by an Active Treatment Extension | Interventional | Phase 1 | Not recruiting | p_1 os_nte st_plc p_Oint st_int state_California country_United States state_Florida state_Maryland state_Massachusetts state_Minnesota state_Alberta country_Canada state_New Brunswick state_Ontario state_Quebec NCT04948645 |
ALS and Airway Clearance (ALSAC) Is There a Best Therapy for Airway Clearance in Patients With ALS | Interventional | N/A | Not recruiting | p_NA os_nte p_Oint st_int state_Texas country_United States NCT04947436 |
Relationship Between N-trimethylamine Oxide, a Metabolite of Intestinal Flora, and Pathogenesis and Progression of Amyotrophic Lateral Sclerosis | Observational | N/A | Not recruiting | os_nte st_obs country_China NCT04948346 |
A Phase 3, Multi-Center, Double-Blind, Randomized, Placebo-Controlled Trial to Evaluate the Efficacy and Safety of Reldesemtiv in Patients With Amyotrophic Lateral Sclerosis (ALS)![]() | Interventional | Phase 3 | Not recruiting | p_3 os_nte st_plc _NAT st_int country_United States state_Arizona state_California state_Colorado state_District of Columbia state_Florida state_Illinois state_Indiana state_Iowa state_Kansas state_Maryland state_Massachusetts state_Michigan state_Missouri state_Nebraska state_New York state_North Carolina state_Ohio state_Oregon state_Pennsylvania state_Tennessee state_Texas state_Vermont state_Virginia state_Wisconsin state_New South Wales country_Australia state_Queensland state_South Australia state_Western Australia country_Belgium state_Alberta country_Canada state_New Brunswick state_Ontario state_Quebec state_Saskatchewan country_Denmark country_France country_Germany state_Dublin country_Ireland country_Italy country_Netherlands country_Poland country_Portugal country_Spain country_Sweden country_Switzerland country_United Kingdom NCT04944784 |
A Study to Investigate the Feasibility of Administration of a Speech Battery and the Use of Speech-based Biomarkers for the Clinical Assessment of Common Neurodegenerative and Psychiatric Disorders in a Remote Setting. | Observational [Patient Registry] | N/A | Not recruiting | os_nte st_obs state_Greater London country_United Kingdom NCT04939818 |
A Multicenter, Randomized, Double-blind, Placebo-controlled, Phase 1b/2a Study of WVE-004 Administered Intrathecally to Patients With C9orf72-associated Amyotrophic Lateral Sclerosis (ALS) or Frontotemporal Dementia (FTD) | Interventional | Phase 1/Phase 2 | Not recruiting | p_1 p_2 os_nte st_plc p_Oint C9orf72 st_int state_New South Wales country_Australia state_Queensland state_Western Australia country_Belgium state_Ontario country_Canada state_Quebec country_Ireland country_Netherlands country_New Zealand country_Sweden country_United Kingdom NCT04931862 |
Investigation of EEG and TMS-based Biomarkers of Amyotrophic Lateral Sclerosis, Multiple Sclerosis and Frontotemporal Dementia | Observational | N/A | Recruiting | os_enr st_obs state_Leinster country_Ireland NCT04918251 |
A Phase I Tolerability, Safety, Pharmacokinetics and Preliminary Efficacy Study of Oral Monepantel in Individuals With Motor Neurone Disease | Interventional | Phase 1 | Recruiting | p_1 os_enr st_wad p_Oint st_int state_New South Wales country_Australia state_Victoria NCT04894240 |
Home Telemonitoring of Bulbar Function by Acoustic Measurement of Swallowing and Speech Sounds in ALS | Observational | N/A | Recruiting | os_enr st_obs state_Pennsylvania country_United States NCT04889898 |
Inspiratory Muscle Training in Respiratory Capacity, Heart Rate Variability, Life Quality and Emotional State in Patients With Amyotrophic Lateral Sclerosis. | Interventional | N/A | Not recruiting | p_NA os_nte p_Oint st_int state_Madrid country_Spain NCT04889248 |
China Amyotrophic Lateral Sclerosis Registry of Patients With Traditional Chinese Medicine | Observational [Patient Registry] | N/A | Recruiting | os_enr st_obs country_China NCT04885374 |
Continuous Measurement of Activity in Patients With Muscle Pathology and in Control Subjects | Interventional | N/A | Recruiting | p_NA os_enr p_Oint st_int country_Belgium NCT04882904 |
Anti-Cholinergic Receptors Antibodies and Dysautonomia Symptoms Relationships in Pure Autonomic Failure, Amyotrophic Lateral Sclerosis, Postural Orthostatic Tachycardia Syndrome: a Pathophysiology Based Therapeutic New Strategy. | Interventional | N/A | Not recruiting | p_NA os_nte p_Oint st_int country_Italy NCT04875949 |
Contribution of Whole Body Muscle MRI for Early Diagnosis of Amyotrophic Lateral Sclerosis. | Interventional | N/A | Recruiting | p_NA os_enr p_Oint st_int country_France NCT04868994 |
Remotely Supervised Transcranial Direct Current Stimulation for Slowing Disease Progression in Amyotrophic Lateral Sclerosis (ALS) | Interventional | N/A | Recruiting | p_NA os_enr st_plc p_Oint st_int Brain Plasticity Lab state_Illinois country_United States NCT04866771 |
Staging System in Amyotrophic Lateral Sclerosis | Observational | N/A | Recruiting | os_enr st_obs country_France NCT04858555 |
A Phase 3 Randomized, Placebo-Controlled Trial With a Longitudinal Natural History Run-In and Open-Label Extension to Evaluate BIIB067 Initiated in Clinically Presymptomatic Adults With a Confirmed Superoxide Dismutase 1 Mutation![]() | Interventional | Phase 3 | Recruiting | p_3 os_enr st_plc _NAT SOD1 st_int country_United States state_Arizona state_California state_Florida state_Georgia state_Illinois state_Maryland state_Massachusetts state_Missouri state_New York state_Texas state_New South Wales country_Australia country_Belgium country_Brazil state_Alberta country_Canada state_Ontario state_Quebec country_France country_Germany country_Italy state_Kagoshima-Ken country_Japan state_Tokyo-To country_Korea, Republic of country_Poland country_Spain country_Sweden state_Staffordshire country_United Kingdom NCT04856982 ATLAS |
Clinical Trial in Phase II of Intramuscular Infusion of Autologous Bone Marrow Stem Cells in Patients With Amyotrophic Lateral Sclerosis. | Interventional | Phase 2 | Not yet recruiting | p_2 os_nye st_plc st_int country_Spain NCT04849065 |
A Randomized, Double-blind, Parallel Group, Single Centre, Phase 1b/2 Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Three Orally Administered Doses of Enoxacin (200mg Twice Daily, 400mg Twice Daily and 600mg Twice Daily) in Adults With Amyotrophic Lateral Sclerosis | Interventional | Phase 1/Phase 2 | Not recruiting | p_1 p_2 os_nte st_plc p_Oint st_int state_Quebec country_Canada NCT04840823 |
Frequency of SOD1 and C9orf72 Gene Mutations in French ALS | Observational | N/A | Not recruiting | os_nte st_obs country_France NCT04819555 |
Efficacy and Tolerability of Beta Hydroxybutyrate Ester in Patients With Amyotrophic Lateral Sclerosis (ALS) | Interventional | N/A | Recruiting | p_NA os_enr p_Oint st_int state_Baden-Wurttemberg country_Germany NCT04820478 |
Safety and Clinical Effects of Repeated Intrathecal Injections of Autologous Mesenchymal Stem Cells in Patients With Amyotrophic Lateral Sclerosis (ALS) | Interventional | Phase 1/Phase 2 | Not recruiting | p_1 p_2 os_nte st_wad p_Oint st_int NCT04821479 |
Expression Profile Study of Macrophages From Patients Affected by Amyotrophic Lateral Sclerosis (ALS) or Other Related Motor Impairments | Observational | N/A | Recruiting | os_enr st_obs country_France NCT04816227 |
Effectiveness of Two Oral Appliances on the Degree of Satisfaction of Patients With Amyotrophic Lateral Sclerosis for Managing Oral Self-biting Injuries: a Randomized Crossover Study | Interventional | N/A | Not recruiting | p_NA os_nte p_Oint st_int state_L'Hospitalet De Llobregat country_Spain NCT04809675 |
Xavier Electromyographic Wheelchair Control for Limited Mobility Patients | Interventional | N/A | Not recruiting | p_NA os_nte p_Oint st_int state_Florida country_United States NCT04800926 |
"Patient's TeleMonitoring With Amyotrophic Lateral Sclerosis Treated by Non Invasive Ventilation at Home." Tele Monitoring Ventilation At Home (TM-VAH) | Interventional | N/A | Recruiting | p_NA os_enr p_Oint st_int country_France NCT04797845 |
Geometrical Facial Deformation According to Posture and Non-invasive Ventilation Mask Virtual Fit in Amyotrophic Lateral Sclerosis | Observational | N/A | Not recruiting | os_nte st_obs state_Gyeongnam country_Korea, Republic of NCT04798183 |
Targeting Metabolic Flexibility in ALS (MetFlex); Safety and Tolerability of Trimetazidine for the Treatment of ALS | Interventional | Phase 2 | Not recruiting | p_2 os_nte st_wad st_int state_Queensland country_Australia country_Netherlands country_United Kingdom NCT04788745 |
A Phase 1-3 Study to Evaluate the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of Intrathecally Administered ION363 in Amyotrophic Lateral Sclerosis Patients With Fused in Sarcoma Mutations (FUS-ALS)![]() | Interventional | Phase 3 | Recruiting | p_3 os_enr st_plc _NAT FUS st_int country_United States state_California state_Maryland state_Massachusetts state_Missouri state_New York state_Ohio state_Utah state_VL-Brabant country_Belgium state_Quebec country_Canada country_Italy country_Korea, Republic of country_Netherlands country_United Kingdom NCT04768972 |
A Randomized, Double-Blind, Placebo-Controlled, Phase 2 Study to Assess Efficacy, Long Term Safety and Tolerability of RT001 in Subjects With Amyotrophic Lateral Sclerosis | Interventional | Phase 2 | Recruiting | p_2 os_enr st_plc st_int country_Estonia country_Latvia country_Netherlands country_Sweden NCT04762589 |
A Phase 1 Study to Assess the Safety and Tolerability of PET Imaging With [11C]CPPC [5-cyano-N-(4-(4-[11C]Methylpiperazin-1-yl)-2-(Piperidin-1-yl)Phenyl)Furan-2-carboxamide] Radioligand in Patients With Amyotrophic Lateral Sclerosis | Interventional | Phase 1 | Recruiting | p_1 os_enr st_wad p_Oint st_int Johns Hopkins University state_Maryland country_United States NCT04749433 |
Phase 1/2 Study of Bosutinib in Patients With Amyotrophic Lateral Sclerosis (ALS) | Interventional | Phase 1/Phase 2 | Recruiting | p_1 p_2 os_enr st_wad p_Oint st_int country_Japan NCT04744532 |
A Double-blind, Randomized, Multicenter, Placebo-Controlled, Parallel, Phase III Clinical Trial to Evaluate the Efficacy and Safety of Lenzumestrocel(Neuronata-R® Inj.) in Patients With Amyotrophic Lateral Sclerosis | Interventional | Phase 3 | Recruiting | p_3 os_enr st_plc st_int state_Kyungsangnam-do country_Korea, Republic of NCT04745299 |
Determining the Feasibility, Acceptability, and Potential Effectiveness of Sharing Video Recordings of Multidisciplinary ALS Clinics With Patients and Their Caregivers | Interventional | N/A | Not recruiting | p_NA os_nte p_Oint st_int state_New Hampshire country_United States NCT04719403 |
University of Pennsylvania Centralized Observational Research Repository on Neurodegenerative Disease (UNICORN) | Observational | N/A | Recruiting | os_enr p_Oint st_obs University of Pennsylvania state_Pennsylvania country_United States NCT04715399 |
A Virtual Peer-to-peer Support Programme for Family Caregivers of Individuals With Motor Neurone Disease at Risk of Becoming or Currently Technology-dependent: Randomised Controlled Trial | Interventional | N/A | Recruiting | p_NA os_enr p_Oint st_int country_United Kingdom NCT04695210 |
New Magnetic Resonance Imaging Biomarkers in Amyotrophic Lateral Sclerosis | Interventional | N/A | Recruiting | p_NA os_enr p_Oint st_int country_France NCT04691011 |
Analysis of Capillary Retinal and Papillary Vascularization in Patients With Amyotrophic Lateral Sclerosis | Interventional | N/A | Recruiting | p_NA os_enr p_Oint st_int country_France NCT04686110 |
A Bridged Phase 1, Randomized, Double-blind, Placebo-controlled Study to Investigate the Safety, Tolerability, and Pharmacokinetics of Multiple Doses of TBN in Healthy Subjects | Interventional | Phase 1 | Not yet recruiting | p_1 os_nye st_plc p_Oint st_int NCT04667013 |
Impact of the Combined Treatment of Curcumin and Resveratrol Liposomed Polyphenols With G04CB02 on the Clinical Improvement of ALS Patients | Interventional | Phase 2 | Not recruiting | p_2 os_nte st_plc st_int country_Spain NCT04654689 |
The Evaluation of the Effect of Wharton's Jelly Mesenchymal Stem Cells (WJMSCs) on the Immune System of Patients With Amyotrophic Lateral Sclerosis (ALS) | Interventional | Phase 1/Phase 2 | Not recruiting | p_1 p_2 os_nte st_wad p_Oint st_int country_Poland NCT04651855 |
A Phase 2a, Double-Blind, Randomized, Placebo-Controlled, Multicenter Study to Assess the Safety of Engensis in Participants With Amyotrophic Lateral Sclerosis | Interventional | Phase 2 | Not recruiting | p_2 os_nte st_plc st_int Helixmith Co., Ltd. state_Arizona country_United States state_Illinois state_Maryland state_Texas country_Korea, Republic of NCT04632225 |
A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Evaluate the Efficacy and Safety of Pegcetacoplan in Subjects With Amyotrophic Lateral Sclerosis (ALS) | Interventional | Phase 2 | Not recruiting | p_2 os_nte st_plc st_int country_United States state_California state_Colorado state_Florida state_Georgia state_Indiana state_Maryland state_Minnesota state_New York state_Texas state_Vermont state_New South Wales country_Australia state_Queensland state_Victoria country_Belgium country_Czechia country_France country_Germany country_Ireland country_Italy country_Japan country_Netherlands country_Poland country_Spain country_Ukraine country_United Kingdom NCT04579666 |
A Phase 3, Multi-center, Open-label, Safety Extension Study of Oral Edaravone Administered Over 96 Weeks in Subjects With Amyotrophic Lateral Sclerosis (ALS) | Interventional | Phase 3 | Not recruiting | p_3 os_nte st_wad st_int Mitsubishi Tanabe Pharma Development America, Inc. country_United States state_Arizona state_Arkansas state_Colorado state_Florida state_Georgia state_Maryland state_Nebraska state_North Carolina state_Pennsylvania state_Tennessee state_Texas state_Wisconsin state_Alberta country_Canada state_Quebec state_Cedex 1 country_France state_Marcland state_Hessen country_Germany state_Lower Saxony state_Lombardia country_Italy state_Piemonte state_Aichi country_Japan state_Chiba state_Fukuoka state_Fukushima state_Hokkaido state_Ishikawa state_Kagawa state_Kanagawa state_Kumamoto state_Miyagi state_Niigata state_Osaka state_Shiga state_Shizuoka state_Tokyo NCT04577404 |
Exploratory Evaluation of [11C]MPC6827 Pharmacokinetics With Positron Emission Tomography (PET) | Interventional | Phase 1 | Recruiting | p_1 os_enr st_wad p_Oint st_int Columbia University state_New York country_United States NCT04575727 |
A Phase 2a Safety, Tolerability, Pharmacokinetic (PK), and Pharmacodynamic (PD) Study of Intravenous ANX005 in Subjects With Amyotrophic Lateral Sclerosis (ALS) | Interventional | Phase 2 | Recruiting | p_2 os_enr st_wad st_int country_United States state_Arizona state_California state_Florida state_New York state_Alberta country_Canada state_New Brunswick state_Ontario state_Quebec NCT04569435 |
A Phase 3b, Multicenter, Randomized, Double-Blind Study to Evaluate Efficacy and Safety of Oral Edaravone Administered for a Period of 48 Weeks in Subjects With Amyotrophic Lateral Sclerosis (ALS) | Interventional | Phase 3 | Not recruiting | p_3 os_nte st_plc st_int Mitsubishi Tanabe Pharma Development America, Inc. country_United States state_Arizona state_Arkansas state_California state_Colorado state_Florida state_Georgia state_Illinois state_Louisiana state_Maryland state_Massachusetts state_Minnesota state_Nebraska state_Nevada state_New York state_Pennsylvania state_Tennessee state_Texas state_Vermont state_Virginia state_Washington state_West Virginia state_Wisconsin state_Alberta country_Canada state_New Brunswick state_Ontario state_Quebec state_Saskatchewan state_Lower Saxony country_Germany state_Nordrhein-Westfalen state_Piemonte country_Italy state_Aichi country_Japan state_Chiba state_Fukuoka state_Fukushima state_Hiroshima state_Hokkaido state_Ishikawa state_Kagawa state_Kanagawa state_Kumamoto state_Kyoto state_Miyagi state_Niigata state_Osaka state_Saitama state_Shiga state_Shizuoka state_Tokyo country_Korea, Republic of state_BE country_Switzerland NCT04569084 |
A Randomized Placebo-controlled Trial of Nicotinamide/Pterostilbene Supplement in ALS: The NO-ALS Study | Interventional | N/A | Recruiting | p_NA os_enr p_Oint st_int country_Norway NCT04562831 |
COVID-19 Amyotrophic Lateral Sclerosis (ALS) Registry | Observational [Patient Registry] | N/A | Not recruiting | os_nte p_Oint st_obs Neurosciences Institute state_North Carolina country_United States NCT04559009 |
Open Label Study: Treatment of ALS Fatigue With PolyMVA | Interventional | Phase 1 | Not recruiting | p_1 os_nte st_wad p_Oint st_int University of Missouri-Columbia School of Medicine state_Missouri country_United States NCT04557410 |
Randomized, Parallel Safety and Efficacy Study of Lipoic Acid in Patients With Amyotrophic Lateral Sclerosis | Interventional | N/A | Not recruiting | p_NA os_nte p_Oint st_int state_Zhejiang country_China NCT04518540 |
AMX0035 for Amyotrophic Lateral Sclerosis - Compassionate Use Protocol | Interventional | Phase 2/Phase 3 | Not recruiting | p_2 p_3 os_nte st_wad st_int state_California country_United States state_Massachusetts state_Michigan state_North Carolina NCT04516096 |
A Randomized, Double-blind, Placebo-controlled Pilot Study to Evaluate the Biological Activity, Safety, and Pharmacokinetics of PU-AD in Subjects With Amyotrophic Lateral Sclerosis (ALS) | Interventional | Phase 2 | Not recruiting | p_2 os_nte st_plc st_int NCT04505358 |
An Open-label, Single-center, 6-month Trial of Theracurmin for Patients With Amyotrophic Lateral Sclerosis (ALS) | Interventional | Phase 2 | Not recruiting | p_2 os_nte st_wad st_int Duke University Medical Center state_North Carolina country_United States NCT04499963 |
A Phase 1/2 Multiple-Ascending-Dose Study With a Long-Term Open-Label Extension to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Effect on Disease Progression of BIIB105 Administered Intrathecally to Adults With Amyotrophic Lateral Sclerosis With or Without Poly-CAG Expansion in the Ataxin-2 Gene![]() | Interventional | Phase 1/Phase 2 | Recruiting | p_1 p_2 os_enr st_plc _NAT p_Oint Ataxin-2 st_int country_United States state_California state_District of Columbia state_Florida state_Georgia state_Maryland state_Massachusetts state_Missouri state_Pennsylvania state_Utah state_Quebec country_Canada country_Italy country_Netherlands NCT04494256 ALSpire |
Remote Pulmonary Function Testing and Nurse Respiratory Health Coaching in Amyotrophic Lateral Sclerosis | Interventional | N/A | Recruiting | p_NA os_enr p_Oint st_int Hershey Medical Center ALS Clinic state_Pennsylvania country_United States NCT04490148 |
Optimizing BCI-FIT: Brain Computer Interface - Functional Implementation Toolkit | Interventional | N/A | Recruiting | p_NA os_enr p_Oint st_int Oregon Health & Science University state_Oregon country_United States NCT04468919 |
Quantifying Fatigue of the Respiratory and Swallowing Musculature in Patients With Amyotrophic Lateral Sclerosis | Interventional | N/A | Not recruiting | p_NA os_nte p_Oint st_int University of Pittsburgh Medical Center Presbyterian Hospital state_Pennsylvania country_United States NCT04468191 |
A Study on the Natural History and Clinical Features of Amyotrophic Lateral Sclerosis (ALS) in Mainland China | Observational | N/A | Recruiting | os_enr st_obs country_China NCT04454892 |
A Clinical Study on Safety and Effectiveness of Intravenous Infusion Plasma From Healthy Young People to Treat Amyotrophic Lateral Sclerosis | Interventional | Phase 1 | Not recruiting | p_1 os_nte st_wad p_Oint st_int country_China NCT04454840 |
To Evaluate the Correlation Between Peripheral Neurofilament Levels and Clinical Subtypes of Amyotrophic Lateral Sclerosis and the Severity of Peripheral Motor Axonal Involvement. | Observational | N/A | Not recruiting | os_nte st_obs country_China NCT04455542 |
Venous Disease Thromboembolic and Amyotrophic Lateral Sclerosis | Observational | N/A | Not recruiting | os_nte st_obs country_France NCT04446325 |
Validazione Italiana Dello Strumento BBI (Beaumont Behavioural Inventory) Per la Valutazione Delle Alterazioni Comportamentali Nel Paziente Affetto da Malattia Del Motoneurone | Observational | N/A | Not recruiting | os_nte st_obs country_Italy NCT04440644 |
Respiratory Complications Associated With ALS and Their Treatments | Observational | N/A | Not recruiting | os_nte st_obs country_United Kingdom NCT04430686 |
A Phase IIa, Randomized, Open-label, Multi-Center, Multi-Dose Study to Evaluate the Effects of ALZT-OP1a in Subjects With Mild-Moderate Stage Amyotrophic Lateral Sclerosis (ALS) | Interventional | Phase 2 | Not recruiting | p_2 os_nte st_wad st_int AZTherapies, Inc. country_United States state_California state_Florida state_New York state_North Carolina state_Oregon NCT04428775 |
Social Cognition in Patients With Amyotrophic Lateral Sclerosis | Interventional | N/A | Recruiting | p_NA os_enr p_Oint st_int country_France NCT04406675 |
An Observational Study to Assess Clinical Manifestations and Biomarkers in Amyotrophic Lateral Sclerosis Type 4 and Other Inherited Neurological Disorders of RNA Processing. | Observational | N/A | Recruiting | os_enr p_Oint st_obs National Institutes of Health Clinical Center state_Maryland country_United States NCT04394871 |
Efficacy of Transcranial Static Magnetic Field Stimulation (tSMS) in Amyotrophic Lateral Sclerosis (ALS). | Interventional | N/A | Recruiting | p_NA os_enr p_Oint st_int country_Italy NCT04393467 |
The Safety and Effectiveness of Cholinergic Receptor Block Therapy in the Treatment of Amyotrophic Lateral Sclerosis | Interventional | Phase 2 | Not yet recruiting | p_2 os_nye st_int state_Shanghai country_China NCT04391361 |
Brain Computer Interface Prototype Development for Assisted Alternative Communication in ALS | Interventional | N/A | Not yet recruiting | p_NA os_nye st_wad p_Oint st_int state_Provence Alpes Cote d'Azur country_France NCT04380649 |
ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) | Observational | N/A | Recruiting | os_enr p_Oint st_obs Mayo Clinic country_United States state_Alabama state_California state_Colorado state_Florida state_Georgia state_Illinois state_Indiana state_Maryland state_Massachusetts state_Michigan state_Minnesota state_Missouri state_Nevada state_New York state_North Carolina state_Ohio state_Pennsylvania state_Tennessee state_Texas state_Washington state_British Columbia country_Canada state_Ontario NCT04363684 |
Neurobiological and Neuro-immunological Mechanisms of Dyspnea in Amyotrophic Lateral Sclerosis | Interventional | N/A | Not yet recruiting | p_NA os_nye st_wad p_Oint st_int NCT04332198 |
Registration Study of Natural History and Clinical Characteristics of Amyotrophic Lateral Sclerosis (ALS) in Mainland China | Observational [Patient Registry] | N/A | Not recruiting | os_nte st_obs state_Beijing country_China NCT04328675 |
A Sequential Dose-Escalation, Randomized, Active-Controlled, Multi-Center, Phase 1/2a Clinical Trial to Evaluate the Safety, Tolerability and Efficacy of SNR1611 in Patients With Amyotrophic Lateral Sclerosis | Interventional | Phase 1/Phase 2 | Not recruiting | p_1 p_2 os_nte st_wad p_Oint st_int country_Korea, Republic of NCT04326283 |
A Phase 2a Open-Label, Multi-Center Study to Evaluate the Safety and Tolerability of Multiple Doses of AT-1501 in Adults With ALS | Interventional | Phase 2 | Not recruiting | p_2 os_nte st_wad st_int state_Arizona country_United States state_California state_Georgia state_Indiana state_Kansas state_Maryland state_Massachusetts state_New York state_Oregon state_Texas country_Canada NCT04322149 |
A Treatment Continuation Study for Patients With Amyotrophic Lateral Sclerosis/Motor Neuron Disease Who Have Successfully Complete Study CMD-2019-001 | Interventional | Phase 2 | Not recruiting | p_2 os_nte st_wad st_int state_New South Wales country_Australia NCT04313166 |
The Reliability and Validity of Turkish Version of ''The Dyspnea-ALS-Scale (DALS-15)" | Observational | N/A | Not recruiting | os_nte st_obs country_Turkey NCT04305639 |
Motor Neurone Disease - Systematic Multi-Arm Adaptive Randomised Trial | Interventional | Phase 2/Phase 3 | Recruiting | p_2 p_3 os_enr st_plc st_int state_County Armagh country_United Kingdom NCT04302870 |
HEALEY ALS Platform Trial![]() | Interventional | Phase 2/Phase 3 | Recruiting | p_2 p_3 os_enr st_plc _NAT st_int Healey Center for ALS at Massachusetts General Hospital state_Massachusetts country_United States state_Arizona state_California state_Colorado state_Connecticut state_District of Columbia state_Florida state_Georgia state_Idaho state_Illinois state_Indiana state_Iowa state_Kansas state_Kentucky state_Louisiana state_Maryland state_Michigan state_Minnesota state_Missouri state_Nebraska state_New Hampshire state_New York state_North Carolina state_Ohio state_Oregon state_Pennsylvania state_Tennessee state_Texas state_Utah state_Virginia state_Washington state_Wisconsin state_Nevada state_New Jersey NCT04297683-NEALS |
Cortico-Spinal tDCS as Rehabilitative Intervention in Amyotrophic Lateral: a Randomized, Double-blind, Sham-controlled Trial Followed by an Open-label Phase | Interventional | N/A | Not recruiting | p_NA os_nte p_Oint st_int state_BS country_Italy NCT04293484 |
An Extension Study to Assess the Long-Term Safety, Tolerability, Pharmacokinetics, and Effect on Disease Progression of BIIB078 Administered to Previously Treated Adults With C9ORF72-Associated Amyotrophic Lateral Sclerosis | Interventional | Phase 1 | Not recruiting | p_1 os_nte st_wad p_Oint st_int state_California country_United States state_Florida state_Georgia state_Maryland state_Massachusetts state_Missouri state_Nebraska state_New York state_Tennessee state_Alberta country_Canada state_Ontario state_Quebec country_Netherlands country_Switzerland state_Greater London country_United Kingdom state_South Yorkshire NCT04288856 |
Radicava® (Edaravone) Findings in Biomarkers From ALS (REFINE-ALS)![]() | Observational | N/A | Recruiting | os_enr _NAT p_Oint st_obs Massachusetts General Hospital state_Massachusetts country_United States state_Arizona state_California state_Colorado state_District of Columbia state_Florida state_Maryland state_Michigan state_Nebraska state_Nevada state_Ohio state_Pennsylvania state_Utah state_Wisconsin state_Ontario country_Canada NCT04259255 |
Understanding Palliative Care and End of Life Needs in the ALS Population: The First Step to Improving Patient and Caregiver Quality of Life | Interventional | N/A | Not recruiting | p_NA os_nte p_Oint st_int state_Ontario country_Canada NCT04257760 |
Clinical Pharmacology Study of Oral Edaravone in Amyotrophic Lateral Sclerosis Patients With Gastrostomy | Interventional | Phase 1 | Not recruiting | p_1 os_nte st_wad p_Oint st_int country_Japan NCT04254913 |
A Phase 3, Double-Blind, Randomized, Placebo-Controlled, Parallel Group, Multicenter Study With an Open-Label Extension to Evaluate the Efficacy and Safety of Ravulizumab in Patients With Amyotrophic Lateral Sclerosis (ALS) | Interventional | Phase 3 | Not recruiting | p_3 os_nte st_plc st_int country_United States state_Arizona state_California state_Colorado state_Florida state_Illinois state_Indiana state_Kansas state_Kentucky state_Maryland state_Massachusetts state_Nevada state_New York state_North Carolina state_Ohio state_Pennsylvania state_Tennessee state_Texas state_Vermont state_Virginia state_Washington state_New South Wales country_Australia state_Queensland state_Western Australia country_Belgium state_Alberta country_Canada state_New Brunswick state_Ontario state_Quebec state_Saskatchewan country_Denmark state_Alpes Maritimes country_France state_Haute Vienne state_Herault state_Indre Et Loire state_Rhone state_Baden Wuerttemberg country_Germany state_Bayern state_Niedersachsen state_Thueringen country_Ireland country_Israel country_Italy state_Aichi-Ken country_Japan state_Chiba-Ken state_Miyagi-Ken state_Niigata-Ken state_Shiga-Ken state_Tokushima-Ken state_Tokyo-To country_Netherlands country_Poland state_Barcelona country_Spain country_Sweden country_Switzerland state_Greater London country_United Kingdom state_West Midlands NCT04248465 |
A Clinical Investigation of the Safety and Efficacy of Clenbuterol on Motor Function in Individuals With Amyotrophic Lateral Sclerosis | Interventional | Phase 2 | Not recruiting | p_2 os_nte st_wad st_int Duke University Medical Center state_North Carolina country_United States NCT04245709 |
Mitochondrial Capacity Boost in ALS (MICABO-ALS) Trial | Interventional | Phase 2 | Recruiting | p_2 os_enr st_wad st_int state_Texas country_United States NCT04244630 |
Tolerability, Safety and Efficacy of Sigh During Non-invasive Mechanical Ventilation in Patients With Motor Neuron Disease- A Pilot Study | Interventional | N/A | Not recruiting | p_NA os_nte p_Oint st_int country_Italy NCT04240925 |
Salivary Raman Fingerprint as Biomarker for the Diagnosis of Amyotrophic Lateral Sclerosis | Observational | N/A | Recruiting | os_enr st_obs country_Italy NCT04233099 |
Comparison Between Breath Stacking Technique Associated With Expiratory Muscle Training and Breath Stacking Technique in Amyotrophic Lateral Sclerosis Patients: a Randomized Single Blind Trial | Interventional | N/A | Not recruiting | p_NA os_nte p_Oint st_int state_DF country_Brazil NCT04226144 |
Phase 2/3 Trial of Autologous Hybrid TREG/Th2 Cell (RAPA-501) Therapy for Amyotrophic Lateral Sclerosis | Interventional | Phase 2/Phase 3 | Recruiting | p_2 p_3 os_enr st_wad st_int Rapa Therapeutics LLC country_United States state_Massachusetts state_New Jersey NCT04220190 |
A Single-Center, Open Label Study to Assess the Safety and Tolerability of Metformin in Subjects With C9orf72 Amyotrophic Lateral Sclerosis Over 24 Weeks of Treatment | Interventional | Phase 2 | Recruiting | p_2 os_enr st_wad C9orf72 st_int UF Health at the University of Florida state_Florida country_United States NCT04220021 |
Clinical Pharmacology Study of Oral Edaravone in Patients With Amyotrophic Lateral Sclerosis (ALS) | Interventional | Phase 1 | Not recruiting | p_1 os_nte st_wad p_Oint st_int country_Japan NCT04176224 |
Safety and Tolerability of Fat-rich vs. Carbohydrate-rich High-caloric Food Supplements in Patients With Amyotrophic Lateral Sclerosis (ALS) | Interventional | Phase 1 | Not recruiting | p_1 os_nte p_Oint st_int state_Baden-Wurttemberg country_Germany NCT04172792 |
Open Label Study to Evaluate the Safety, Tolerability and Preliminary Efficacy of Ciprofloxacin/Celecoxib Combination in Patients With ALS | Interventional | Phase 2 | Not recruiting | p_2 os_nte st_wad st_int country_Israel NCT04165850 |
A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Amyotrophic Lateral Sclerosis | Observational | N/A | Recruiting | os_enr p_Oint st_obs ProgenaBiome state_California country_United States NCT04150809 |
The Efficacy and Safety of Vitamin E Mixed Tocotrienols In Patients With Amyotrophic Lateral Sclerosis (ALS) : A Pilot Exploratory Study | Interventional | Phase 2 | Not recruiting | p_2 os_nte st_plc st_int country_Malaysia NCT04140136 |
The Ontario Neurodegenerative Disease Research Initiative | Observational | N/A | Not recruiting | os_nte st_obs state_Ontario country_Canada NCT04104373 |
A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study in Early Symptomatic Amyotrophic Lateral Sclerosis Patients on Stable Background Therapy to Assess Bioenergetic Catalysis With CNM-Au8 to Slow Disease Progression in ALS. | Interventional | Phase 2 | Not recruiting | p_2 os_nte st_plc st_int country_Australia state_New South Wales NCT04098406 |
Oxidative Markers and Efficacy in Amyotrophic Lateral Sclerosis (ALS) Phenotypes Treated With Edaravone | Observational | N/A | Recruiting | os_enr p_Oint st_obs Loma Linda University state_California country_United States NCT04097158 |
Open Label, Off Label Study to Evaluate the Safety, Tolerability and Preliminary Efficacy of Ciprofloxacin/Celecoxib Combination in Patients With ALS | Interventional | Phase 1 | Not recruiting | p_1 os_nte st_wad p_Oint st_int country_United States state_Arizona NCT04090684 |
Validation of the "Exspiron©" in Patients With Amyotrophic Lateral Sclerosis; Non-invasive Monitoring of Respiratory Volume. | Interventional | N/A | Not yet recruiting | p_NA os_nye st_wad p_Oint st_int NCT04089696 |
A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase 2 Study of Cu(II)ATSM in Patients With Amyotrophic Lateral Sclerosis/Motor Neuron Disease | Interventional | Phase 2/Phase 3 | Not recruiting | p_2 p_3 os_nte st_plc st_int country_Australia state_New South Wales NCT04082832 |
An Open-label, Adaptive Design Study in Patients With Amyotrophic Lateral Sclerosis (ALS) to Characterize Safety, Tolerability and Brain Microglia Response, as Measured by TSPO Binding, Following Multiple Doses of BLZ945 Using Positron Emission Tomography (PET) With the Radioligand [11C]-PBR28 | Interventional | Phase 2 | Recruiting | p_2 os_enr st_wad st_int country_United States state_Connecticut state_Massachusetts state_New York country_Finland country_Sweden NCT04066244 |
A Phase 2b/3, Multi-Center, Randomized, Double-Blind, Placebo-Controlled, 12 Month Clinical Trial to Evaluate the Efficacy and Safety of MN-166 (Ibudilast) Followed by Open-Label Extension Phase in Subjects With Amyotrophic Lateral Sclerosis | Interventional | Phase 2/Phase 3 | Recruiting | p_2 p_3 os_enr st_plc st_int country_United States state_California state_Florida state_Georgia state_Indiana state_Kansas state_Maryland state_Minnesota state_New York state_North Carolina state_Oregon state_Pennsylvania state_Virginia state_Washington state_Alberta country_Canada state_Ontario state_Quebec state_Saskatchwean NCT04057898 COMBAT-ALS |
Phase 2a Study of the Expansion and Infusion of Autologous T-Regulatory Cells in Amyotrophic Lateral Sclerosis![]() | Interventional | Phase 2 | Not recruiting | p_2 os_nte st_plc _NAT st_int Houston Methodist Hospital state_Texas country_United States state_Massachusetts NCT04055623 |
Biomarkers in Neurodegenerative Diseases | Observational [Patient Registry] | N/A | Not recruiting | os_nte st_obs state_Minnesota country_United States NCT04055532 |
The E-health Application To Modify ORal Energy Intake and Measure Outcomes REmotely in ALS Clinical Trial (EAT MORE2)![]() | Observational | N/A | Not recruiting | os_nte _NAT p_Oint st_obs Massachusetts General Hospital state_Massachusetts country_United States NCT04051333 |
Real World Testing of a Brain-Computer Interface to Operate a Commercial Augmentative and Alternative Communication System | Observational | N/A | Recruiting | os_enr p_Oint st_obs University of Pittsburgh state_Pennsylvania country_United States NCT04026581 |
A Registered Cohort Study on Amyotrophic Lateral Sclerosis | Observational | N/A | Recruiting | os_enr st_obs state_Fujian country_China NCT04008329 |
A Pilot Study to Assess Transmembrane Electromyography (TM-EMG) for the Assessment of Neuromuscular Function in the Oropharynx | Interventional | N/A | Not recruiting | p_NA os_nte p_Oint st_int SENTA Clinic state_California country_United States NCT03986671 |
New Therapeutic Strategy in ALS Based on Metabolic Status and Associated Metabolic Pathways. | Interventional | N/A | Recruiting | p_NA os_enr p_Oint st_int country_France NCT03984708 |
A Multicenter, Open Label, Single-Ascending Dose Study to Evaluate Safety, Tolerability, and Pharmacokinetics of AP-101 in Familial and Sporadic Amyotrophic Lateral Sclerosis (ALS) | Interventional | Phase 1 | Not recruiting | p_1 os_nte st_wad p_Oint st_int state_Ontario country_Canada state_Quebec NCT03981536 |
Adaptation of a Psychological Therapy for Patients With ALS - a Pilot Study | Interventional | N/A | Not recruiting | p_NA os_nte p_Oint st_int state_Saxony country_Germany NCT03975608 |
Effects of Oral Levosimendan (ODM-109) on Respiratory Function in Patients With ALS: Open-Label Extension for Patients Completing Study 3119002 | Interventional | Phase 3 | Not recruiting | p_3 os_nte st_wad st_int state_Massachusetts country_United States state_Arizona state_California state_Connecticut state_District of Columbia state_Florida state_Georgia state_Illinois state_Maryland state_Michigan state_Minnesota state_Missouri state_Nebraska state_New York state_North Carolina state_Ohio state_Oregon state_Pennsylvania state_Texas state_Utah state_Washington state_New South Wales country_Australia state_Queensland state_South Australia state_Victoria state_Western Australia state_Tyrol country_Austria state_Upper Austria country_Belgium state_Alberta country_Canada state_New Brunswick state_Ontario state_Quebec country_Finland country_France country_Germany country_Ireland country_Italy country_Netherlands country_Spain country_Sweden country_United Kingdom NCT03948178 |
A Phase 1, Double-Blind, Placebo-Controlled, Single-Ascending-Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of BIIB100 Administered Orally to Adult Participants With Amyotrophic Lateral Sclerosis | Interventional | Phase 1 | Not recruiting | p_1 os_nte st_plc p_Oint st_int country_United States state_Arizona state_California state_Florida state_Maryland state_Massachusetts state_Missouri state_Nebraska state_Tennessee NCT03945279 |
Outcomes Mandate National Integration With Cannabis as Medicine | Interventional | Phase 2 | Recruiting | p_2 os_enr st_wad st_int state_Florida country_United States state_Ohio NCT03944447 |
Sinemet in ALS and PLS | Interventional | Phase 1 | Not recruiting | p_1 os_nte st_plc p_Oint st_int state_Missouri country_United States NCT03929068 |
Restore Motor Function Through Robotic Arm Exoskeleton and Brain Computer Interface | Interventional | N/A | Not recruiting | p_NA os_nte p_Oint st_int country_Denmark NCT03900247 |
A Pilot Study of Repetitive Transcranial Magnetic Stimulation for Improvement of Apathy in Amyotrophic Lateral Sclerosis | Interventional | N/A | Not recruiting | p_NA os_nte p_Oint st_int country_Poland NCT03892382 |
A Pilot Study of Repetitive Transcranial Magnetic Stimulation for Improvement of Depression in Amyotrophic Lateral Sclerosis | Interventional | N/A | Not recruiting | p_NA os_nte st_plc p_Oint st_int country_Poland NCT03892863 |
Systematic Laryngoscopic Evaluation of Upper Airways in Ventilated Amyotrophic Lateral Sclerosis (ALS) Patients in Portugal and in Norway | Interventional | N/A | Not recruiting | p_NA os_nte st_wad p_Oint st_int state_Hordaland country_Norway country_Portugal NCT03887338 |
Impact of Nuedexta on Bulbar Physiology and Function in ALS | Interventional | Phase 1/Phase 2 | Not recruiting | p_1 p_2 os_nte st_wad p_Oint st_int University of Florida state_Florida country_United States NCT03883581 |
Evaluation of Microglial Activation Using the PET Imaging Ligand [18F]PBR06 in Patients With Amyotrophic Lateral Sclerosis Compared to Healthy Volunteers | Interventional | Phase 1 | Not recruiting | p_1 os_nte st_wad p_Oint st_int state_Connecticut country_United States NCT03876002 |
Speech Analysis in ALS Patients With and Without Cognitive Abnormalities: Evaluation of Sensitivity and Disease Progression | Observational | N/A | Not recruiting | os_nte p_Oint st_obs Barrow Neurological Institute state_Arizona country_United States NCT03868345 |
Amyotrophic Lateral Sclerosis (ALS) Families Project | Observational | N/A | Recruiting | os_enr p_Oint st_obs Columbia University state_New York country_United States NCT03865420 |
Effects of Remote Ischemic Conditioning on Hand Use in Individuals With Spinal Cord Injury and Amyotrophic Lateral Sclerosis: A Preliminary Study | Interventional | N/A | Not recruiting | p_NA os_nte p_Oint st_int James J. Peters VA Medical Center state_New York country_United States NCT03851302 |
A Phase 2, Pilot Open Label, Sequential Group, Investigator Blinded Study of Magnetic Resonance Spectroscopy (31P-MRS) to Assess the Effects of CNM-Au8 for the Bioenergetic Improvement of Impaired Neuronal Redox State in Amyotrophic Lateral Sclerosis | Interventional | Phase 2 | Not recruiting | p_2 os_nte st_wad st_int state_Texas country_United States NCT03843710 |
Open Label, Non-randomized Extension Trial to Assess Long Term Safety and Efficacy of Arimoclomol in Subjects With Amyotropic Lateral Sclerosis Who Have Completed the ORARIALS-01 Trial | Interventional | Phase 3 | Not recruiting | p_3 os_nte st_wad st_int state_Arizona country_United States state_California state_Florida state_New York state_Oregon state_Pennsylvania state_Virginia country_Belgium state_Ontario country_Canada country_France country_Germany country_Italy country_Netherlands country_Poland country_Spain country_Sweden country_United Kingdom NCT03836716 |
Randomized, Double-blind, Safety and Efficacy of Recombinant Human Erythropoietin in Amyotrophic Lateral Sclerosis | Interventional | Phase 1/Phase 2 | Recruiting | p_1 p_2 os_enr st_plc p_Oint st_int country_Korea, Republic of NCT03835507 |
A Prospective, Non-randomized, Open Label Study to Assess the Safety and the Efficacy of Autologous Multipotent Mesenchymal Stromal Cells in the Treatment of Amyotrophic Lateral Sclerosis | Interventional | Phase 1/Phase 2 | Not recruiting | p_1 p_2 os_nte st_wad p_Oint st_int NCT03828123 |
EEG Based Awareness Detection and Communication in Prolonged Disorders of Consciousness and Physical Disability | Interventional | N/A | Recruiting | p_NA os_enr p_Oint st_int country_Ireland state_Warwickshire country_United Kingdom NCT03827187 |
Neurodevice Phase I: Wireless Implantable Neurodevice Microsystem for Neuroprosthesis and Neuroscience | Interventional | N/A | Not recruiting | p_NA os_nte st_wad p_Oint st_int country_Singapore NCT03811301 |
Sequential High-density Surface Electromyography (HDSEMG) Recordings in Motor Neurone Disease: Fasciculations as a Biomarker of Motor Neurone Health | Interventional | N/A | Not recruiting | p_NA os_nte st_wad p_Oint st_int country_United Kingdom NCT03809845 |
Department of Physical Medicine & Rehabilitation, Taipei Veterans General Hospital | Observational | N/A | Not recruiting | os_nte st_obs state_TW country_Taiwan NCT03806634 |
Taipei Veterans General Hospital | Observational | N/A | Not recruiting | os_nte st_obs state_TW country_Taiwan NCT03806647 |
Safety and Efficacy of Tauroursodeoxycholic (TUDCA) as add-on Treatment in Patients Affected by Amyotrophic Lateral Sclerosis (ALS) | Interventional | Phase 3 | Not recruiting | p_3 os_nte st_plc st_int country_Belgium country_France country_Germany country_Ireland country_Italy country_Netherlands country_United Kingdom NCT03800524 |
A Pilot Study to Evaluate the Use of the MN4000 for Treatment of Cystic Fibrosis (CF) and Motor Neuron Disease (MND) Patients in the Home Setting | Interventional | N/A | Not recruiting | p_NA os_nte st_wad p_Oint st_int state_Illinois country_United States NCT03797677 |
Perampanel Single Ascending Dose Transcranial Magnetic Stimulation Biomarker Study in Amyotrophic Lateral Sclerosis | Interventional | Phase 1 | Not recruiting | p_1 os_nte st_plc p_Oint st_int Mayo Clinic state_Florida country_United States NCT03793868 |
Inhibition of Rho Kinase (ROCK) With Fasudil as Disease-modifying Treatment for ALS | Interventional | Phase 2 | Not recruiting | p_2 os_nte st_plc st_int country_France country_Germany country_Switzerland NCT03792490 |
Development and Needs Assessment and Efficiency of Smart Communication System for Patients With ALS | Interventional | N/A | Not recruiting | p_NA os_nte st_wad p_Oint st_int country_Taiwan NCT03787420 |
Interplay Between Gut Microbiota and Adaptive Immunity in Amyotrophic Lateral Sclerosis: a Clinical Trial | Interventional | N/A | Not recruiting | p_NA os_nte p_Oint st_int country_Italy NCT03766321 |
An Observational Study in People With Amyotrophic Lateral Sclerosis to Validate Tidal /End-Tidal CO2, Measured by the N-Tidal C™ Against Directly Measured PaCO2 and to Determine the Ease of Home Use of the Device | Observational | N/A | Not recruiting | os_nte st_obs state_Cambridge country_United Kingdom NCT03764384 |
A Multicenter, Randomized, Placebo-Controlled, Double-Blind, Phase 1b Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of DNL747 in Subjects With Amyotrophic Lateral Sclerosis | Interventional | Phase 1 | Not recruiting | p_1 os_nte st_plc p_Oint st_int state_Florida country_United States state_Utah state_South Holland country_Netherlands NCT03757351 |
An Open-Label, Multi-Center, Follow up Study to Protocol 101/2 - Continued Treatment by Intravenously Administered IPL344 to Amyotrophic Lateral Sclerosis (ALS) Patients | Interventional | Phase 2 | Not recruiting | p_2 os_nte st_wad st_int country_Israel NCT03755167 |
Treatment of FUS-Related ALS With Betamethasone - The TRANSLATE Study | Interventional | Phase 1 | Not recruiting | p_1 os_nte st_wad p_Oint st_int University of Kentucky Medical Center state_Kentucky country_United States NCT03707795 |
A Phase II Pilot Single-arm Safety and Tolerability Study of ILB in Patients With Motor Neurone Disease (MND)/ Amyotrophic Lateral Sclerosis (ALS) | Interventional | Phase 2 | Not recruiting | p_2 os_nte st_wad st_int University Hospitals Birmingham NHS Foundation Trust state_West Midlands country_United Kingdom NCT03705390 |
Colchicine for Amyotrophic Lateral Sclerosis: a Phase II, Randomized, Double Blind, Placebo Controlled, Multicenter Clinical Trial | Interventional | Phase 2 | Not recruiting | p_2 os_nte st_plc st_int country_Italy NCT03693781 |
Evaluation and Characterization of Infraclinical Sensory Deficits in Amyotrophic Lateral Sclerosis by Brain Imaging and Electrophysiology | Interventional | N/A | Not recruiting | p_NA os_nte st_wad p_Oint st_int country_France NCT03694132 |
A Randomised, Double-blind, Single-centre Study on the Safety, Tolerability and Efficacy of Cannabis Based Medicine Extract (MediCabilis CBD Oil) in Slowing the Disease Progression in Amyotrophic Lateral Sclerosis or Motor Neurone Disease Patients | Interventional | Phase 3 | Not recruiting | p_3 os_nte st_plc st_int Gold Coast Hospital and Health Service state_Queensland country_Australia NCT03690791 |
Ultrasonography of the Neuromuscular Degeneration Behavior in ALS: a Longitudinal Study | Observational [Patient Registry] | N/A | Not recruiting | os_nte st_obs state_Murcia country_Spain NCT03683875 |
A Single Center Study to Evaluate the Effect of Riluzole Oral Soluble Film on Swallowing Safety in Individuals With Amyotrophic Lateral Sclerosis | Interventional | Phase 2 | Not recruiting | p_2 os_nte st_wad st_int state_Florida country_United States NCT03679975 |
Assessing Motor Neuron Disease Pathophysiology by Two Novel Methods - Threshold Tracking Transcranial Magnetic Stimulation and Magnetic Resonance Spectroscopy | Observational | N/A | Not recruiting | os_nte st_obs country_Denmark country_Turkey NCT03664206 |
Dietary Approach to Improving QoL in ALS | Interventional | N/A | Not recruiting | p_NA os_nte st_wad p_Oint st_int NCT03659422 |
A Phase I Study to Determine the Maximum Tolerated Dose (MTD) of HK-001 and to Evaluate Its Pharmacokinetic Profile in Healthy Volunteers | Interventional | Phase 1 | Not recruiting | p_1 os_nte st_plc p_Oint st_int country_Taiwan NCT03651349 |
Phase 1/2a, Multi-center, Open-Label, Dose-escalating Study to Assess Safety, Tolerability, and Pharmacokinetics of Intravenously Administered IPL344 for The Treatment of Amyotrophic Lateral Sclerosis (ALS) | Interventional | Phase 1/Phase 2 | Not recruiting | p_1 p_2 os_nte st_wad p_Oint st_int country_Israel NCT03652805 |
Acute Intermittent Hypoxia and Breathing in Neuromuscular Disease | Interventional | N/A | Recruiting | p_NA os_enr p_Oint st_int University of Florida state_Florida country_United States NCT03645031 |
A Phase 1 Multiple-Ascending-Dose Study to Assess the Safety, Tolerability, and Pharmacokinetics of BIIB078 Administered Intrathecally to Adults With C9ORF72-Associated Amyotrophic Lateral Sclerosis | Interventional | Phase 1 | Not recruiting | p_1 os_nte st_plc p_Oint st_int state_California country_United States state_Florida state_Georgia state_Maryland state_Massachusetts state_Missouri state_Nebraska state_New York state_Tennessee state_Alberta country_Canada state_Ontario state_Quebec country_Ireland country_Netherlands country_Switzerland state_Greater London country_United Kingdom state_South Yorkshire NCT03626012 |
Neuromuscular Magnetic Stimulation Counteracts Muscle Decline in ALS Patients | Interventional | Phase 2 | Not recruiting | p_2 os_nte st_int NCT03618966 |
A Single-centre, Open Single-arm Study Where the Safety, Tolerability and Efficacy of Subcutaneously Administered ILB Will be Evaluated in Patients With Amyotrophic Lateral Sclerosis | Interventional | Phase 2 | Not recruiting | p_2 os_nte st_wad st_int country_Sweden NCT03613571 |
Understanding Communication and Cognitive Impairments in Neurodegenerative Disorders | Interventional | N/A | Not recruiting | p_NA os_nte p_Oint st_int University of Missouri-Columbia state_Missouri country_United States state_Kansas NCT03613038 |
Measuring the Effects of a Music Therapy Protocol on Respiratory and Bulbar Functions of Patients With Early and Mid-stage Amyotrophic Lateral Sclerosis: Mixed Methods Single Case Study Series | Interventional | N/A | Not recruiting | p_NA os_nte st_wad p_Oint st_int country_Russian Federation state_Cambridgeshire country_United Kingdom NCT03604822 |
Tolerability and Efficacy of L-Serine in Patients With Amyotrophic Lateral Sclerosis: A Phase IIa Study | Interventional | Phase 2 | Not recruiting | p_2 os_nte st_wad st_int Dartmouth-Htichcock Medical Center state_New Hampshire country_United States NCT03580616 |
Cognitive Impairment in ALS: Screening Tools, Experiences and Prognosis | Observational | N/A | Recruiting | os_enr st_obs country_Norway NCT03578796 |
Cognitive Impairment in ALS: Screening Tools, Experiences and Prognosis | Observational | N/A | Recruiting | os_enr st_obs country_Norway NCT03579017 |
Presymptomatic Neuromuscular Junction Defects and Compensatory Mechanisms in Amyotrophic Lateral Sclerosis (ALS) | Interventional | N/A | Not recruiting | p_NA os_nte st_wad p_Oint st_int country_France NCT03573466 |
Investigation on the Cortical Communication (CortiCom) System | Interventional | N/A | Recruiting | p_NA os_enr p_Oint st_int Johns Hopkins Medicine state_Maryland country_United States NCT03567213 |
Identification of Acoustic and Perceptual Markers of Lower and Upper Motor Neuron Signs in Dysarthria of Patients With Amyotrophic Lateral Sclerosis : a Comparison With Primitive Lateral Sclerosis, Kennedy's Disease and Controls | Observational | N/A | Not recruiting | os_nte st_obs country_France NCT03560661 |
Japanese Early-stage Clinical Trial of Ultra-high Dose Methylcobalamin for Amyotrophic Lateral Sclerosis: a Pivotal Phase 3 Randomized Controlled Study | Interventional | Phase 3 | Not recruiting | p_3 os_nte st_plc st_int state_Aichi country_Japan state_Hiroshima state_Hokkaido state_Hyogo state_Ishikawa state_Kanagawa state_Shiga NCT03548311 |
Neurofeedback Rehabilitation Based on Motor Imaging in Patients in the Immobilization Phase | Interventional | N/A | Not recruiting | p_NA os_nte st_wad p_Oint st_int country_France NCT03545451 |
BHV-0223 Expanded Access Protocol in Patients With Amyotrophic Lateral Sclerosis | Expanded Access | N/A | No longer available | p_NA p_Oint st_ea country_United States NCT03537807 |
Cohort Study: Multidisciplinary Follow-up of Patients With Amyotrophic Lateral Sclerosis | Observational | N/A | Not recruiting | os_nte st_obs country_Switzerland NCT03536962 |
Open-Label Study to Evaluate Safety, Tolerability and Pharmacokinetics of Multiple Doses of BHV-0223 in Subjects With Amyotrophic Lateral Sclerosis | Interventional | Phase 1 | Not recruiting | p_1 os_nte st_wad p_Oint st_int country_United States state_Florida state_Nebraska state_North Carolina state_Tennessee state_Texas NCT03520517 |
A Pilot Study of the Utility of 3D Printed Masks for ALS Subjects | Interventional | N/A | Not recruiting | p_NA os_nte st_wad p_Oint st_int state_Michigan country_United States NCT03519880 |
REducing Disparities in the QUALity of Palliative Care for Older African Americans Through Improved Advance Care Planning (EQUAL ACP) | Interventional | N/A | Recruiting | p_NA os_enr p_Oint st_int state_Alabama country_United States state_Georgia state_South Carolina state_Texas NCT03516994 |
A Phase 2, Randomised, Double-Blind, Placebo-Controlled Study of IC14 for Treatment of Patients With Rapidly Progressive Motor Neuron Disease | Interventional | Phase 2 | Not recruiting | p_2 os_nte st_plc st_int state_Queensland country_Australia NCT03508453 |
A Pilot Trial of Triheptanoin for People With Amyotrophic Lateral Sclerosis (PALS) | Interventional | Phase 1/Phase 2 | Not recruiting | p_1 p_2 os_nte st_wad p_Oint st_int Duke University state_North Carolina country_United States NCT03506425 |
Effects of Oral Levosimendan (ODM-109) on Respiratory Function in Patients With ALS![]() | Interventional | Phase 3 | Not recruiting | p_3 os_nte st_plc _NAT st_int Massachusetts General Hospital state_Massachusetts country_United States state_Arizona state_California state_Colorado state_Connecticut state_District of Columbia state_Florida state_Georgia state_Illinois state_Kentucky state_Maryland state_Michigan state_Minnesota state_Missouri state_Nebraska state_New York state_North Carolina state_Ohio state_Oregon state_Pennsylvania state_Texas state_Utah state_Vermont state_Washington state_Wisconsin state_New South Wales country_Australia state_Queensland state_South Australia state_Victoria state_Western Australia state_Tyrol country_Austria state_Upper Austria state_Flemish Brabant country_Belgium state_Liege state_Oost-Vlaanderen state_Alberta country_Canada state_New Brunswick state_Ontario state_Quebec country_Finland country_France state_Baden-Württemberg country_Germany state_Hessen state_Mecklenburg-western-pommerania state_Niedersachsen state_Nordrhein-westfalen state_Nordrhein-Westfalen state_Sachsen state_Thuringen country_Ireland country_Italy state_Noord-Holland country_Netherlands state_Vizcaya country_Spain state_Vasterbotten country_Sweden state_England country_United Kingdom NCT03505021 |
A Phase 3, Randomised, Placebo-Controlled Trial of Arimoclomol in Amyotropic Lateral Sclerosis | Interventional | Phase 3 | Not recruiting | p_3 os_nte st_plc st_int state_Arizona country_United States state_California state_Florida state_Kansas state_New York state_Oregon state_Pennsylvania state_Texas state_Virginia country_Belgium state_Ontario country_Canada state_Quebec country_France country_Germany country_Italy country_Netherlands country_Poland country_Spain country_Sweden country_Switzerland country_United Kingdom NCT03491462 |
Open Label Extension Study of AMX0035 in Patients With ALS | Interventional | Phase 2 | Not recruiting | p_2 os_nte st_wad st_int Massachusetts General Hospital state_Massachusetts country_United States NCT03488524 |
EH301 for the Treatment of Amyotrophic Lateral Sclerosis: a Placebo-Controlled Study | Interventional | N/A | Not recruiting | p_NA os_nte st_plc p_Oint st_int country_Spain NCT03489200 |
A Phase 1b, Open-Label, Dose-Escalation, Safety and Pharmacokinetic Study of IC14 in Motor Neurone Disease | Interventional | Phase 1 | Not recruiting | p_1 os_nte st_wad p_Oint st_int state_Queensland country_Australia NCT03487263 |
Nutritional Prognostic Factors in Patients With Amyotrophic Lateral Sclerosis and Percutaneous Endoscopic Gastrostomy | Observational | N/A | Not recruiting | os_nte st_obs country_Italy NCT03487536 |
A Phase I/IIa, Open Label, Dose-escalating Clinical Study to Evaluate the Safety, Tolerability and Theraputic Effects of Transplantation of Astrocytes Derived From Human Embryonic Stem Cells (hESC), in Patients With Amyotrophic Lateral Sclerosis (ALS) | Interventional | Phase 1/Phase 2 | Not recruiting | p_1 p_2 os_nte st_wad p_Oint st_int Hadassah Ein Kerem Medical Center country_Israel NCT03482050 |
Pharyngeal Electrical Stimulation in Amyotrophic Lateral Sclerosis: A Pilot Study With 20 Patients | Interventional | Phase 1/Phase 2 | Not recruiting | p_1 p_2 os_nte p_Oint st_int country_Germany NCT03481348 |
A Phase 2a, Open-Label Biomarker Study of IC14 for the Treatment of Patients With | Interventional | Phase 2 | Not recruiting | p_2 os_nte st_wad st_int state_Queensland country_Australia NCT03474263 |
Safety and Efficacy of Ranolazine for the Treatment of Amyotrophic Lateral Sclerosis | Interventional | Phase 2 | Not recruiting | p_2 os_nte st_wad st_int University of Kansas Medical Center state_Kansas country_United States NCT03472950 |
A Multi-Center, Open Label Study to Assess the Safety and Tolerability of Riluzole Oral Soluble Film in Subjects With Amyotrophic Lateral Sclerosis Over 12 Weeks of Twice Daily Treatment. | Interventional | Phase 2 | Not recruiting | p_2 os_nte st_wad st_int country_United States state_Texas NCT03457753 |
The Effect of RNS60 on ALS Biomarkers | Interventional | Phase 2 | Not recruiting | p_2 os_nte st_plc st_int IRCCS Istituto di ricerche farmacologiche Mario Negri di Milano country_Italy state_Massachusetts country_United States NCT03456882 |
Predictive Factors for the Diagnosis of Early Noninvasive Ventilation Equipment in Patients With Amyotrophic Lateral Sclerosis | Interventional | N/A | Recruiting | p_NA os_enr p_Oint st_int country_France NCT03452618 |
SOD1 Kinetics Measurements in ALS Patients | Observational | N/A | Not recruiting | os_nte p_Oint st_obs Washington University in St. Louis state_Missouri country_United States NCT03449212 |
The Relationship Between Arterial Stiffness and Respiratory Failure: Using Motor Neurone Disease as a Paradigm to Assess the Consequence of Sleep Disordered Breathing on Arterial Stiffness | Observational | N/A | Not recruiting | os_nte st_obs country_United Kingdom NCT03444428 |
Safety and Tolerability of High Dose Biotin in Patients With Amyotrophic Lateral Sclerosis | Interventional | Phase 2 | Not recruiting | p_2 os_nte st_int country_Lebanon NCT03427086 |
Noninvasive Cervical Electrical Stimulation for ALS: Mechanistic and Safety Study | Interventional | N/A | Not recruiting | p_NA os_nte p_Oint st_int state_New York country_United States NCT03411863 |
Increased Resting Energy Expenditure Compared to Six Predictive Theoretical Equations in Amyotrophic Lateral Sclerosis: a Study Versus Controls | Observational | N/A | Not recruiting | os_nte st_obs country_France NCT03382392 |
Safety and Tolerability of Perampanel in Amyotrophic Lateral Sclerosis Patients | Interventional | Phase 2 | Not recruiting | p_2 os_nte st_wad st_int country_Lebanon NCT03377309 |
Optic Coherence Tomography in Patients With Amyotrophic Lateral Sclerosis | Interventional | N/A | Not recruiting | p_NA os_nte p_Oint st_int NCT03377868 |
Resting Energy Expenditure Equations in Amyotrophic Lateral Sclerosis, Creation of a ALS-specific Equation | Observational | N/A | Not recruiting | os_nte st_obs country_France NCT03378375 |
Epidemiology and Genetics of the Amyotrophic Lateral Sclerosis in the French West Indies | Interventional | N/A | Not recruiting | p_NA os_nte p_Oint st_int country_Guadeloupe country_Martinique NCT03367650 |
Investigation of the Epidemiological Factors Associated With the Development of Amyotrophic Lateral Sclerosis (ALS) | Observational [Patient Registry] | N/A | Recruiting | os_enr st_obs country_Israel NCT03366506 |
Novel MRI Biomarkers for Monitoring Disease Progression in ALS | Observational | N/A | Recruiting | os_enr p_Oint st_obs University of Alberta country_Canada state_Florida country_United States state_Utah state_Alberta state_British Columbia state_Ontario state_Quebec NCT03362658 |
Rapamycin (Sirolimus) Treatment for Amyotrophic Lateral Sclerosis | Interventional | Phase 2 | Not recruiting | p_2 os_nte st_plc st_int country_Italy NCT03359538 |
An Observational Proof-of-concept Study to Explore the Waveform Characteristics of Tidal Breathing Carbon Dioxide (CO2), Measured Using the N-Tidal C™ Device, in Different Breathing Conditions. | Observational | N/A | Not recruiting | os_nte st_obs state_Hampshire country_United Kingdom NCT03356288 |
An Open Label Study to Evaluate the Safety and Efficacy of FLX-787-ODT for Treatment of Fasciculations in the Tongue and Upper or Lower Extremity Muscles Most Affected in Subjects With Amyotrophic Lateral Sclerosis (ALS) | Interventional | Phase 1/Phase 2 | Not recruiting | p_1 p_2 os_nte st_wad p_Oint st_int country_United States state_North Carolina NCT03338114 |
An Open Label Study to Evaluate the Safety and Efficacy of FLX-787-ODT for Treatment of Fasciculations in the Tongue and One Appendicular Muscle in Adult Subjects With Amyotrophic Lateral Sclerosis (ALS) | Interventional | Phase 1/Phase 2 | Not recruiting | p_1 p_2 os_nte st_wad p_Oint st_int country_United States state_Massachusetts NCT03334786 |
Functional Assessment of the Melanopsin-Containing Retinal Ganglion Cells in Progressive Supranuclear Palsy Using Chromatic Pupillometry | Observational | N/A | Not recruiting | os_nte st_obs state_Massachusetts country_United States NCT03330353 |
The Role of Moderate Aerobic Exercise as Determined by Cardiopulmonary Exercise Testing in ALS | Interventional | N/A | Not recruiting | p_NA os_nte p_Oint st_int NCT03326622 |
A Study of Protein Metabolism, Microbiome and Investigational Probiotic Use in Patients With Amyotrophic Lateral Sclerosis (ALS) | Interventional | N/A | Not recruiting | p_NA os_nte st_wad p_Oint st_int state_South Dakota country_United States NCT03324399 |
Safety and Feasibility of Primary Motor Cortex Blood-Brain Barrier Opening Using Transcranial MR-Guided Focused Ultrasound With Intravenous Ultrasound Contrast Agent in Patients With Amyotrophic Lateral Sclerosis | Interventional | N/A | Not recruiting | p_NA os_nte st_wad p_Oint st_int state_Ontario country_Canada NCT03321487 |
Safety and Efficacy of Intraspinal Transplantation of Autologous ADRC in ALS Patients | Interventional | Phase 1 | Not recruiting | p_1 os_nte st_wad p_Oint st_int country_Poland NCT03296501 |
Conservative Iron Chelation as a Disease-modifying Strategy in Amyotrophic Lateral Sclerosis: Multicentre, Parallel-group, Placebo-controlled, Randomized Clinical Trial of Deferiprone | Interventional | Phase 2/Phase 3 | Not recruiting | p_2 p_3 os_nte st_plc st_int country_France NCT03293069 |
Rehabilitative Trial With Transcranial Direct Current Stimulation (tDCS) in Amyotrophic Lateral Sclerosis | Interventional | N/A | Not recruiting | p_NA os_nte p_Oint st_int state_BS country_Italy NCT03293394 |
Relationship Between Neurological Disability and Visual Impairment in Patients With ALS or Friedreich's Ataxia | Observational | N/A | Not recruiting | os_nte st_obs country_Spain NCT03285204 |
A Phase 3, Randomized Double-Blind, Placebo-Controlled Multicenter Study to Evaluate Efficacy and Safety of Repeated Administration of NurOwn® (Autologous Mesenchymal Stem Cells Secreting Neurotrophic Factors) in Participants With ALS | Interventional | Phase 3 | Not recruiting | p_3 os_nte st_plc st_int country_Israel state_California country_United States state_Massachusetts state_Minnesota NCT03280056 |
Treatment Effect of Edaravone in Patients With Amyotrophic Lateral Sclerosis (ALS) in a Representative Iranian Population | Interventional | Phase 2/Phase 3 | Not recruiting | p_2 p_3 os_nte st_wad st_int country_Iran, Islamic Republic of NCT03272802 |
A Phase II Randomized, Placebo-Controlled, Double Blinded, Multi-Centre Clinical Trial of Pimozide in Patients With Amyotrophic Lateral Sclerosis | Interventional | Phase 2 | Not recruiting | p_2 os_nte st_plc st_int University of Calgary state_Alberta country_Canada state_New Brunswick state_Ontario state_Quebec NCT03272503 |
A Phase II Study of Intrathecal Autologous Adipose-derived Mesenchymal Stromal Cells for Amyotrophic Lateral Sclerosis | Interventional | Phase 2 | Not recruiting | p_2 os_nte st_wad st_int Mayo Clinic in Rochester state_Minnesota country_United States state_Arizona state_Florida NCT03268603 |
Expansion and Infusion of T-Regulatory Cells in Amyotrophic Lateral Sclerosis | Interventional | Phase 1 | Not recruiting | p_1 os_nte st_wad p_Oint st_int state_Texas country_United States NCT03241784 |
Investigating Complex Neurodegenerative Disorders Related to Amyotrophic Lateral Sclerosis and Frontotemporal Dementia | Observational | N/A | Recruiting | os_enr p_Oint st_obs National Institutes of Health Clinical Center state_Maryland country_United States NCT03225144 |
Identification of New Biomarkers Useful to Define the Course of Multiple Sclerosis and Study of the Mechanisms That Promote Synaptic Damage | Observational | N/A | Recruiting | os_enr st_obs state_Isernia country_Italy NCT03217396 |
Remote Pulmonary Function Testing in Amyotrophic Lateral Sclerosis (Pilot) | Interventional | N/A | Not recruiting | p_NA os_nte p_Oint st_int state_Pennsylvania country_United States NCT03214224 |
An Open-label, Phase 1 Trial for Safety and Efficacy Study of 2nd Cycle Treatment After 6 Months of 1st Cycle HLA-haplo Matched Allogenic Bone Marrow Derived Stem Cell("HYNR-CS-Allo Inj") Treatment in Amyotrophic Lateral Sclerosis(ALS) | Interventional | Phase 1 | Not recruiting | p_1 os_nte st_wad p_Oint st_int state_Haengdang-dong, Seongdong-gu country_Korea, Republic of NCT03214146 |
A Randomized Clinical Trial, Double Blind, Placebo-controlled of Lithium and Valproate in Amyotrophic Lateral Sclerosis. | Interventional | Phase 2 | Not recruiting | p_2 os_nte st_plc st_int state_Distrito Federal country_Mexico NCT03204500 |
A Pilot Study of Lung Volume Recruitment Combined With Expiratory Muscle Strength Training in ALS | Interventional | N/A | Not recruiting | p_NA os_nte p_Oint st_int University of Minnesota state_Minnesota country_United States state_Florida NCT03202017 |
ALS Study Determining Various Biomarkers and Strength Comparison After Exercise | Interventional | N/A | Not recruiting | p_NA os_nte p_Oint st_int University of Kansas Medical Center state_Kansas country_United States NCT03201991 |
Physiological Flow of Liquids Used in Dysphagia Management | Observational | N/A | Not recruiting | os_nte p_Oint st_obs University Health Network - Toronto Rehabilitation Institute country_Canada state_Florida country_United States NCT03192358 |
Safety of Urate Elevation in Amyotrophic Lateral Sclerosis (ALS)![]() | Interventional | Phase 2 | Not recruiting | p_2 os_nte st_plc _NAT st_int Massachusetts General Hospital state_Massachusetts country_United States state_Florida state_Minnesota NCT03168711 |
A Phase 2, Multi-Center, Double-Blind, Randomized, Dose-Ranging, Placebo-Controlled Study to Evaluate the Efficacy, Safety and Tolerability of CK-2127107 in Patients With Amyotrophic Lateral Sclerosis (ALS)![]() | Interventional | Phase 2 | Not recruiting | p_2 os_nte st_plc _NAT st_int state_Arizona country_United States state_California state_Colorado state_Connecticut state_District of Columbia state_Florida state_Georgia state_Illinois state_Indiana state_Iowa state_Kansas state_Maryland state_Massachusetts state_Michigan state_Minnesota state_Missouri state_Nebraska state_New York state_North Carolina state_Ohio state_Oregon state_Pennsylvania state_Tennessee state_Texas state_Vermont state_Virginia state_Washington state_West Virginia state_Wisconsin state_New South Wales country_Australia state_Queensland state_South Australia state_Western Australia state_Alberta country_Canada state_Ontario state_Quebec state_Saskatchewan country_Ireland country_Netherlands country_Spain NCT03160898 |
A Treatment Continuation Study for Patients With Amyotrophic Lateral Sclerosis/Motor Neuron Disease Who Have Successfully Completed Study CMD-2016-001 | Interventional | Phase 1/Phase 2 | Not recruiting | p_1 p_2 os_nte st_wad p_Oint st_int state_New South Wales country_Australia NCT03136809 |
Phase 3 Study to Compare the Efficacy and Safety of Masitinib in Combination With Riluzole Versus Placebo in Combination With Riluzole in the Treatment of Patients Suffering From Amyotrophic Lateral Sclerosis (ALS) | Interventional | Phase 3 | Recruiting | p_3 os_enr st_plc st_int state_Alabama country_United States state_California state_Kentucky state_Maryland state_Massachusetts state_Virginia country_Belgium country_Denmark country_France country_Germany country_Greece country_Israel state_Modena country_Italy country_Norway country_Poland country_Portugal country_Russian Federation country_Serbia country_Slovenia country_Spain country_Sweden country_Ukraine NCT03127267 |
Evaluation of the Safety, Tolerability, Efficacy and Activity of AMX0035, a Fixed Combination of Phenylbutyrate (PB) and Tauroursodeoxycholic Acid (TUDCA), for the Treatment of ALS![]() | Interventional | Phase 2 | Not recruiting | p_2 os_nte st_plc _NAT st_int Massachusetts General Hospital, NCRI state_Massachusetts country_United States state_Arizona state_California state_Florida state_Georgia state_Iowa state_Kentucky state_Louisiana state_Maryland state_Michigan state_Minnesota state_Missouri state_Nebraska state_New York state_North Carolina state_Ohio state_Oregon state_Pennsylvania state_Texas state_Washington NCT03127514 |
NeuroCognitive Communicator Exploratory Safety Study of an Assistive Neuroprosthetic Device for Patients With Severe Upper Motor Disability. | Interventional | N/A | Recruiting | p_NA os_enr p_Oint st_int state_Ontario country_Canada NCT03100110 |
An Online Mindfulness Intervention for People With ALS and Their Caregivers | Interventional | N/A | Not recruiting | p_NA os_nte p_Oint st_int state_Pennsylvania country_United States NCT03095989 |
Longitudinal Study of Innate Lymphoid Cells in Peripheral Blood in ALS | Observational | N/A | Not recruiting | os_nte p_Oint st_obs University of Michigan state_Michigan country_United States NCT03090932 |
Observational Case-Control Study to Identify Circulating miR-218 as a Possible Non-invasive Biomarker of Amyotrophic Lateral Sclerosis (ALS) | Observational | N/A | Recruiting | os_enr st_obs country_Italy NCT03088839 |
An Extension Study to Assess the Long-Term Safety, Tolerability, Pharmacokinetics, and Effect on Disease Progression of BIIB067 Administered to Previously Treated Adults With Amyotrophic Lateral Sclerosis Caused by Superoxide Dismutase 1 Mutation | Interventional | Phase 3 | Not recruiting | p_3 os_nte st_wad st_int state_Arizona country_United States state_California state_Florida state_Georgia state_Illinois state_Maryland state_Massachusetts state_Minnesota state_Missouri state_Nebraska state_Ohio state_Oregon state_Tennessee country_Belgium state_Alberta country_Canada state_Ontario state_Quebec state_Puy De Dome country_France state_Baden Wuerttemberg country_Germany country_Italy country_Japan country_New Zealand state_South Yorkshire country_United Kingdom NCT03070119 |
A Multicenter, Double Blind, Placebo Controlled Study to Assess the Efficacy and Safety of H.P. Acthar® Gel in the Treatment of Subjects With Amyotrophic Lateral Sclerosis | Interventional | Phase 2/Phase 3 | Not recruiting | p_2 p_3 os_nte st_plc st_int state_Arizona country_United States state_California state_Colorado state_District of Columbia state_Florida state_Georgia state_Indiana state_Kansas state_Kentucky state_Maryland state_Massachusetts state_Michigan state_Nebraska state_Nevada state_New Jersey state_New York state_Oregon state_Pennsylvania state_Tennessee state_Texas state_Vermont state_Virginia state_Washington state_Wisconsin state_Buenos Aires country_Argentina state_Córdoba state_Mendoza state_Santa Fe state_Alberta country_Canada state_Quebec state_Región Metropolitana country_Chile country_Colombia state_Coahuila country_Mexico state_Nuevo Leon state_Querétaro state_Tlalnepantla De Baz state_Veracruz country_Peru NCT03068754 |
Protocol CC100B. CC100: Phase 1 Multiple-Dose Safety and Tolerability in Subjects With ALS | Interventional | Phase 1 | Not recruiting | p_1 os_nte st_plc p_Oint st_int Indiana University, IU Health Physicians Neurology state_Indiana country_United States NCT03049046 |
A Clinical Trial to Evaluate the Safety and Efficacy of Fycompa in Subjects With Amyotrophic Lateral Sclerosis (ALS) | Interventional | N/A | Not recruiting | p_NA os_nte st_plc p_Oint st_int Stony Brook University Medical Center state_New York country_United States NCT03020797 |
ALS Testing Through Home-based Outcome Measures (ALS AT HOME)![]() | Observational | N/A | Not recruiting | os_nte _NAT p_Oint st_obs Barrow Neurological Institute state_Arizona country_United States NCT03016897 |
Nebulized RNS60 for the Treatment of Amyotrophic Lateral Sclerosis | Interventional | Phase 2 | Not yet recruiting | p_2 os_nye st_plc st_int NCT02988297 |
Delineating Physiologic Mechanisms of Swallowing Impairment and Decline in ALS | Observational | N/A | Not recruiting | os_nte p_Oint st_obs University of Florida state_Florida country_United States NCT02962050 |
Human Neural Progenitor Cells Secreting Glial Cell Line-Derived Neurotrophic Factor (CNS10-NPC-GDNF) for the Treatment of Amyotrophic Lateral Sclerosis![]() | Interventional | Phase 1 | Not recruiting | p_1 os_nte _NAT p_Oint st_int Cedars-Sinai Medical Center state_California country_United States NCT02943850 |
A Phase 3, Open-Label Extension Study of Tirasemtiv for Patients With Amyotrophic Lateral Sclerosis (ALS) Who Completed VITALITY-ALS (CY 4031) | Interventional | Phase 3 | Not recruiting | p_3 os_nte st_wad st_int state_Arizona country_United States state_California state_Colorado state_Connecticut state_District of Columbia state_Florida state_Georgia state_Indiana state_Iowa state_Kansas state_Maryland state_Massachusetts state_Michigan state_Minnesota state_Missouri state_New Hampshire state_New York state_North Carolina state_Ohio state_Oregon state_Pennsylvania state_Tennessee state_Texas state_Virginia state_Washington state_West Virginia state_Wisconsin state_Vlaams Brabant country_Belgium state_Alberta country_Canada state_New Brunswick state_Nova Scotia state_Ontario state_Quebec country_France state_Baden-Wuerttemberg country_Germany state_Lower Saxony country_Ireland state_Lombardy country_Italy state_Piemonte country_Netherlands country_Portugal country_Spain country_United Kingdom NCT02936635 |
Case-control and Population Questionnaire Studying Environmental Risk Factors and Neurological Diseases | Observational | N/A | Not recruiting | os_nte p_Oint st_obs Cleveland Clinic Foundation state_Ohio country_United States NCT02916966 |
Pilot Study to Evaluate the Efficacy and Safety of Plasma Exchange With Albutein® 5% in Patients With Amyotrophic Lateral Sclerosis | Interventional | Phase 2 | Not recruiting | p_2 os_nte st_int Dartmouth-Hitchcock Medical Center state_New Hampshire country_United States NCT02872142 |
A Phase 1 Single and Multiple Dose Escalation and Pharmacokinetic Study of Cu(II)ATSM Administered Orally to Patients With Amyotrophic Lateral Sclerosis/Motor Neuron Disease | Interventional | Phase 1 | Not recruiting | p_1 os_nte st_wad p_Oint st_int state_New South Wales country_Australia state_Victoria NCT02870634 |
Amyotrophic Lateral Sclerosis and the Innate Immune System | Observational | N/A | Recruiting | os_enr st_obs country_Denmark NCT02869048 |
A Multicenter, 18-week Open Label Safety and Efficacy Trial of Dalfampridine in Primary Lateral Sclerosis | Interventional | Phase 1 | Not recruiting | p_1 os_nte st_wad p_Oint st_int Hospital for Special Surgery state_New York country_United States state_Florida state_Massachusetts NCT02868567 |
An Open-Label Pilot Study Comparing the Efficacy of Selective Serotonin Re-Uptake Inhibitors (SSRIs) Versus Tricyclic Antidepressants (TCAs) for Treating Depression in Amyotrophic Lateral Sclerosis | Interventional | Phase 1 | Not recruiting | p_1 os_nte st_wad p_Oint st_int Saint Louis University state_Missouri country_United States NCT02851914 |
Fluid Biomarkers With Deep Phenotyping in Patients With ALS![]() | Observational | N/A | Not recruiting | os_nte _NAT p_Oint st_obs Barrow Neurological Institute state_Arizona country_United States state_Michigan state_New York state_Oregon state_Pennsylvania state_South Carolina NCT02819765 |
Neurologic Bone Marrow Derived Stem Cell Treatment Study | Interventional | N/A | Recruiting | p_NA os_enr p_Oint st_int state_Connecticut country_United States state_Florida country_United Arab Emirates NCT02795052 |
A Phase 2 Randomized, Double-Blind, Placebo-Controlled, Multicenter Study of NP001 in Subjects With Amyotrophic Lateral Sclerosis (ALS) and Evidence of Elevated Systemic Inflammation![]() | Interventional | Phase 2 | Not recruiting | p_2 os_nte _NAT st_int Neuraltus country_United States state_Arizona state_California state_Florida state_Georgia state_Kansas state_Kentucky state_Massachusetts state_Minnesota state_Missouri state_New York state_North Carolina state_Ohio state_Oregon state_Texas state_Quebec country_Canada NCT02794857 |
Effect of Mexiletine on Cortical Hyperexcitability in Sporadic Amyotrophic Lateral Sclerosis (SALS)![]() | Interventional | Phase 2 | Not recruiting | p_2 os_nte _NAT st_int MGH - NCRI state_Massachusetts country_United States state_Arizona state_California state_Georgia state_Michigan state_New York state_Pennsylvania state_South Carolina state_Washington NCT02781454 |
A Study to Evaluate the Sensitivity, Specificity, and Overall Accuracy of an Amyotrophic Lateral Sclerosis Diagnostic Test Developed by Iron Horse Diagnostics![]() | Observational | N/A | Not recruiting | os_nte _NAT p_Oint st_obs Cleveland Clinic state_Ohio country_United States NCT02759913 |
A Single-Arm Prospective Investigation of the Effects of Laughter Therapy on Mood, Stress, and Self-Efficacy in People With Central Nervous System Disorders. | Interventional | N/A | Not recruiting | p_NA os_nte p_Oint st_int Evergreen Healthcare state_Washington country_United States NCT02750982 |
A Multi-Center, Open-Label Biomarker Study to Evaluate MN-166 (Ibudilast) in Subjects With Amyotrophic Literal Sclerosis (ALS)![]() | Interventional | Phase 1/Phase 2 | Not recruiting | p_1 p_2 os_nte _NAT p_Oint st_int Massachusetts General Hospital state_Massachusetts country_United States state_New York NCT02714036 |
The Impact of Respiratory Strength Training in Individuals With Amyotrophic Lateral Sclerosis (ALS) | Interventional | Phase 1 | Not recruiting | p_1 os_nte p_Oint st_int UF Health Shands state_Florida country_United States NCT02710110 |
Determination of Accurate Screening Tools for Dysphagia in Amyotrophic Lateral Sclerosis (ALS) | Interventional | Phase 1 | Not recruiting | p_1 os_nte p_Oint st_int University of Florida state_Florida country_United States NCT02710162 |
An Open-label, Single-center, 12-month Trial of a Lunasin Regimen for Patients With Amyotrophic Lateral Sclerosis (ALS) | Interventional | Phase 2 | Not recruiting | p_2 os_nte st_int Duke University state_North Carolina country_United States NCT02709330 |
Understanding Clinical Phenotype and Collecting Biomarker Samples in C9ORF72 ALS![]() | Observational | N/A | Not recruiting | os_nte _NAT p_Oint st_obs Washington University School of Medicine state_Missouri country_United States state_California state_Maryland state_Massachusetts state_New York state_Virginia country_Netherlands NCT02686268 |
Utilization of Pulmonary Clearance Devices in Amyotrophic Lateral Sclerosis | Interventional | N/A | Not recruiting | p_NA os_nte p_Oint st_int Cedars-Sinai Medical Center state_California country_United States NCT02682030 |
DESIPHER Speech Degradation as an Indicator of Physiological Degeneration in ALS | Observational | N/A | Not recruiting | os_nte p_Oint st_obs James A. Haley Veterans' Hospital state_Florida country_United States NCT02675075 |
A Phase I, Double-Blind, Randomized, Placebo-Controlled, Multicenter, Single- and Multiple-Ascending-Dose Study to Determine Initial Safety, Tolerability, and Pharmacokinetics of GDC-0134 in Patients With Amyotrophic Lateral Sclerosis | Interventional | Phase 1 | Not recruiting | p_1 os_nte st_plc p_Oint st_int country_United States state_California state_Florida state_Georgia state_Maryland state_Massachusetts state_North Carolina state_Tennessee state_Quebec country_Canada country_Netherlands NCT02655614 |
A Study to Evaluate the Efficacy, Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of BIIB067 Administered to Adult Subjects With Amyotrophic Lateral Sclerosis and Confirmed Superoxide Dismutase 1 Mutation![]() | Interventional | Phase 3 | Not recruiting | p_3 os_nte st_plc _NAT SOD1 st_int Biogen country_United States state_Arizona state_California state_Florida state_Georgia state_Illinois state_Maryland state_Massachusetts state_Michigan state_Minnesota state_Missouri state_Nebraska state_New York state_Ohio state_Oregon state_Pennsylvania state_Tennessee state_Texas state_New South Wales country_Australia country_Belgium state_Alberta country_Canada state_Ontario state_Quebec country_Denmark country_France state_Baden Wuerttemberg country_Germany country_Italy country_Japan state_Gyeongsangnam-do country_Korea, Republic of country_Poland state_Greater London country_United Kingdom state_South Yorkshire NCT02623699 |
Methodology Study of Novel Electrophysiological, Physical, and Imaging Outcome Measures to Assess the Progression of Amyotrophic Lateral Sclerosis | Observational | N/A | Not recruiting | os_nte p_Oint st_obs country_United States state_California state_Florida state_Georgia state_Maryland state_Massachusetts state_Missouri state_Pennsylvania country_Belgium state_Ontario country_Canada state_Quebec state_Hérault country_France state_Paris country_Germany country_Ireland state_CX country_Netherlands country_Switzerland state_West Midlands country_United Kingdom NCT02611674 |
Multicenter, Randomised, Double-blind, Placebo-controlled, Parallel Group, Phase 2/3 Study to Compare the Efficacy and Safety of Masitinib | Interventional | Phase 2/Phase 3 | Not recruiting | p_2 p_3 os_nte st_int country_United States country_Spain NCT02588677 |
A Longitudinal Study of Imaging Biomarkers in Amyotrophic Lateral Sclerosis (ALS) | Observational | N/A | Not recruiting | os_nte p_Oint st_obs University of Minnesota state_Minnesota country_United States NCT02567136 |
Imaging and BioFluid Biomarkers in Amyotrophic Lateral Sclerosis![]() | Observational | N/A | Not recruiting | os_nte _NAT p_Oint st_obs Massachusetts General Hospital NCRI state_Massachusetts country_United States state_Texas NCT02559869 |
A Pilot Study of RNS60 in Amyotrophic Lateral Sclerosis (ALS)![]() | Interventional | Phase 1 | Not recruiting | p_1 os_nte _NAT p_Oint st_int Mass General Hospital state_Massachusetts country_United States NCT02525471 |
A Phase 3, Multi-National, Double-Blind, Randomized, Placebo-Controlled, Stratified, Parallel Group, Study to Evaluate the Safety, Tolerability and Efficacy of Tirasemtiv in Patients With Amyotrophic Lateral Sclerosis (ALS)![]() | Interventional | Phase 3 | Not recruiting | p_3 os_nte _NAT st_int MD Cytokinetics country_United States state_Arizona state_California state_Colorado state_Connecticut state_District of Columbia state_Florida state_Georgia state_Illinois state_Indiana state_Iowa state_Kansas state_Maryland state_Massachusetts state_Michigan state_Minnesota state_Missouri state_Nebraska state_New Hampshire state_New York state_North Carolina state_Ohio state_Oregon state_Pennsylvania state_Tennessee state_Texas state_Virginia state_Washington state_West Virginia state_Wisconsin state_Vlaams Brabant country_Belgium state_Alberta country_Canada state_New Brunswick state_Nova Scotia state_Ontario state_Quebec country_France state_Baden-Wuerttemberg country_Germany state_Lower Saxony country_Ireland country_Italy country_Netherlands country_Portugal country_Spain state_Devon country_United Kingdom NCT02496767 |
Neurogenic Dysphonia/Dysphagia Registry | Observational [Patient Registry] | N/A | Not recruiting | os_nte p_Oint st_obs country_United States state_California state_Georgia state_Massachusetts state_New York state_North Carolina state_Pennsylvania state_Texas state_Virginia NCT02493491 |
A Phase 1/2a Open-Label Study to Investigate the Safety of the Transplantation (by Injection) of Human Glial Restricted Progenitor Cells (hGRPs; Q-Cells®) Into Subjects With Amyotrophic Lateral Sclerosis (ALS): Assessment of Localized Therapeutic Activity by Blinded Observation and Lateral Transplantation (ALTA-BOLT) | Interventional | Phase 1/Phase 2 | Not yet recruiting | p_1 p_2 os_nye st_wad p_Oint st_int NCT02478450 |
A Phase 2 Randomized, Placebo Controlled Trial of Tocilizumab in ALS Subjects![]() | Interventional | Phase 2 | Not recruiting | p_2 os_nte _NAT st_int Mass General Hospital state_Massachusetts country_United States state_Arizona state_Kansas state_North Carolina state_Pennsylvania NCT02469896 |
Paired Stimulation to Increase Cortical Transmission to Hand Muscles: Pilot Study | Interventional | N/A | Not recruiting | p_NA os_nte p_Oint st_int James J. Peters VA Medical Center state_New York country_United States NCT02469675 |
A Registry-Based Randomized-Controlled, Double-Blinded Clinical Trial of Pimozide in Patients With Neuromuscular Junction Transmission Dysfunction Due to Amyotrophic Lateral Sclerosis | Interventional | Phase 2 | Not recruiting | p_2 os_nte st_int University of Calgary country_United States state_Alberta country_Canada NCT02463825 |
A Phase 2A Safety and Biomarker Study of EPI-589 in Subjects With Amyotrophic Lateral Sclerosis | Interventional | Phase 2 | Not recruiting | p_2 os_nte st_int country_United States state_California state_Oregon NCT02460679 |
Feasibility of a Consumer Based Accelerometer in Monitoring Outpatient Physical Activity: A Study in Patients With Cancer and Amyotrophic Lateral Sclerosis | Observational | N/A | Not recruiting | os_nte p_Oint st_obs Duke University Medical Center state_North Carolina country_United States NCT02457715 |
A Phase 2 Pharmacodynamic Trial of Ezogabine (Retigabine) on Neuronal Excitability in Amyotrophic Lateral Sclerosis![]() | Interventional | Phase 2 | Not recruiting | p_2 os_nte _NAT st_int Mass General Hospital - Neurological Clinical Research Institute state_Massachusetts country_United States state_Arizona state_California state_Florida state_Georgia state_Maryland state_Michigan state_New York state_North Carolina state_Pennsylvania NCT02450552 |
HERV-K Suppression Using Antiretroviral Therapy in Volunteers With Amyotrophic Lateral Sclerosis (ALS) | Interventional | Phase 1 | Not recruiting | p_1 os_nte st_wad p_Oint st_int National Institute of Neurological Disorders and Stroke (NINDS) state_Maryland country_United States NCT02437110 |
Electronic-health Application To Measure Outcomes REmotely Clinical Trial![]() | Interventional | N/A | Not recruiting | p_NA os_nte _NAT p_Oint st_int Mass General Hospital state_Massachusetts country_United States NCT02418546 |
F 18 T807 Tau PET Imaging in Familial Amyotrophic Lateral Sclerosis (IND 123119 Protocol B) | Observational | N/A | Not recruiting | os_nte st_obs Washington University School of Medicine state_Missouri country_United States NCT02414230 |
Accurate Test of Limb Isometric Strength (ATLIS) in ALS | Observational | N/A | Not recruiting | os_nte p_Oint st_obs Cedars-Sinai Medical Center state_California country_United States NCT02374606 |
Rare Diseases Clinical Research Network Advancing Research and Treatment for Frontotemporal Lobar Degeneration [ARTFL]: Research Projects 1 & 2 | Observational | N/A | Not recruiting | os_nte p_Oint st_obs University of California, San Francisco state_California country_United States state_Alabama state_Florida state_Illinois state_Maryland state_Massachusetts state_Minnesota state_Missouri state_New York state_North Carolina state_Ohio state_Pennsylvania state_Washington state_British Columbia country_Canada state_Ontario NCT02365922 |
Study of Predictive Factors of Progression of Motor Neurone Disease Prognosis and Endophenotype Biomarkers French Database Set up | Observational [Patient Registry] | N/A | Recruiting | os_enr st_obs country_France NCT02360891 |
A Multicenter Phase I/II Clinical Trial, Randomized, Controlled With Placebo, Triple Blind to Evaluate Safety, and Indications of Efficiency of the Intravenous Administration of the Therapy With 3 Doses of MSC in Patients With ASL Moderated to Severe | Interventional | Phase 1/Phase 2 | Not recruiting | p_1 p_2 os_nte p_Oint st_int country_Spain NCT02290886 |
A Pilot Study of Inosine in Amyotrophic Lateral Sclerosis (ALS)![]() | Interventional | Phase 1 | Not recruiting | p_1 os_nte _NAT p_Oint st_int Massachusetts General Hospital state_Massachusetts country_United States NCT02288091 |
A Single-center, Randomized, Double-blind, Placebo-controlled, 6-month Trial Followed by an Open-label Extension to Evaluate the Safety, Tolerability and Clinical Endpoint Responsiveness of Ibudilast (MN-166) in Subjects With (ALS)![]() | Interventional | Phase 2 | Not recruiting | p_2 os_nte _NAT st_int Carolinas Healthcare System state_North Carolina country_United States NCT02238626 |
Metabotropic Glutamate Receptor 5 (mGluR5) Imaging in Amyotrophic Lateral Sclerosis (ALS) Patients and Healthy Volunteers | Interventional | N/A | Not recruiting | p_NA os_nte p_Oint st_int Johns Hopkins University state_Maryland country_United States NCT02236897 |
Analysis of Post-Translational Modifications of a Critical Protein Implicated in Amyotrophic Lateral Sclerosis | Observational | N/A | Not recruiting | os_nte p_Oint st_obs UNC Neurology ALS Clinic state_North Carolina country_United States NCT02228915 |
Quantitative Ultrasonography and Electrical Impedance Myography: Speech and Swallowing Technologies for Use in Neurological Disorders | Observational | N/A | Recruiting | os_enr p_Oint st_obs Beth Israel Deaconess Medical Center state_Massachusetts country_United States NCT02118805 |
Phase 2B Study of Memantine for the Treatment of Amyotrophic Lateral Sclerosis | Interventional | Phase 2 | Not recruiting | p_2 os_nte st_plc st_int University of Kansas Medical Center state_Kansas country_United States state_Arizona state_California state_Florida state_Kentucky state_Missouri state_Oregon state_Pennsylvania state_Texas state_Washington NCT02118727 |
Innovative Ultrasound Technology in Neuromuscular Disease (AQUIRe) | Observational | N/A | Not recruiting | os_nte p_Oint st_obs Beth Israel Deaconess Medical Center state_Massachusetts country_United States NCT02104921 |
Immuno-modulation in Amyotrophic Lateral Sclerosis- a Phase II Study of Safety and Activity of Low Dose Interleukin-2 | Interventional | Phase 2 | Not recruiting | p_2 os_nte st_int CHRU de Montpellier - Hôpital Gui de Chauliac country_United States country_France NCT02059759 |
A Phase I/II, Open Label Study to Assess the Safety and Tolerability of VM202 in Subjects With Amyotrophic Lateral Sclerosis | Interventional | Phase 1/Phase 2 | Not recruiting | p_1 p_2 os_nte p_Oint st_int Northwestern University Stem Cell Institute country_United States state_Illinois NCT02039401 |
A Phase 2, Randomized, Double Blind, Placebo Controlled Multicenter Study to Evaluate Safety and Efficacy of Transplantation of Autologous Mesenchymal Stem Cells Secreting Neurotrophic Factors (MSC-NTF) in Patients With ALS | Interventional | Phase 2 | Not recruiting | p_2 os_nte st_int country_United States state_Massachusetts state_Minnesota NCT02017912 |
Noninvasive Assessment of Neuromuscular Disease Using Electrical Impedance![]() | Observational | N/A | Not recruiting | os_nte _NAT p_Oint st_obs Mass General Hospital state_Massachusetts country_United States state_Arizona state_Florida state_New York state_North Carolina NCT02011204 |
Cervical Spinal Cord Metabolism and Microstructure in Amyotrophic Lateral Sclerosis(ALS) | Interventional | N/A | Not recruiting | p_NA os_nte p_Oint st_int University of Michigan state_Michigan country_United States NCT02000713 |
Developing a Discrimination Model to Diagnose ALS Using Advanced MRI Techniques | Interventional | N/A | Not recruiting | p_NA os_nte p_Oint st_int University of Michigan Hospital state_Michigan country_United States NCT01995903 |
A Phase 3, Multicenter, Double-Blind, Placebo-Controlled, Single-Treatment Efficacy and Safety Study of MYOBLOC® (Part A) Followed by Open-Label, Multiple-Treatment With MYOBLOC® (Part B) in the Treatment of Troublesome Sialorrhea in Adult Subjects | Interventional | Phase 3 | Not recruiting | p_3 os_nte st_int country_United States state_California state_Colorado state_District of Columbia state_Florida state_Indiana state_Maryland state_Michigan state_Missouri state_New Jersey state_New York state_Ohio state_Oklahoma state_South Carolina state_Tennessee state_Texas state_Utah state_Washington state_Irkutsk Region country_Russian Federation state_Leningrad Region state_Petrodvorets country_Ukraine NCT01994109 |
Establishment of a Human Tissue Bank for Studying the Microbial Etiology of Neurodegenerative Diseases | Observational | N/A | Not recruiting | os_nte p_Oint st_obs Carolinas Medical Center state_North Carolina country_United States NCT01954875 |
Establishment of a Tissue Bank (Blood, CSF) for the Understanding of the Disease Progression and Early Diagnosis of Motor Neuron Disease (MND). | Observational | N/A | Not recruiting | os_nte p_Oint st_obs Carolinas Medical Center - Dept of Neurology state_North Carolina country_United States NCT01950910 |
Identification of Diagnostic and Prognostic Biomarkers From Amyotrophic Lateral Sclerosis (ALS) Skin and Adipose Samples | Observational | N/A | Not recruiting | os_nte p_Oint st_obs Carolinas Medical Center - Dept of Neurology state_North Carolina country_United States NCT01948102 |
Multi-Center, Randomized Controlled Study of the NeuRx® Diaphragm Pacing System™ (DPS)In Participants With Amyotrophic Lateral Sclerosis (ALS)![]() | Interventional | Phase 2 | Not recruiting | p_2 os_nte _NAT st_int Massachusetts General Hospital state_Massachusetts country_United States state_Arizona state_California state_Connecticut state_Florida state_Iowa state_Michigan state_Missouri state_Nebraska state_New York state_North Carolina state_Ohio state_Oregon state_Pennsylvania state_Texas state_Vermont state_Washington NCT01938495 |
Natural History and Biomarkers of C9ORF72 Amyotrophic Lateral Sclerosis and Frontotemporal Dementia | Observational | N/A | Not recruiting | os_nte p_Oint st_obs National Institutes of Health Clinical Center state_Maryland country_United States NCT01925196 |
A Study to Explore the Safety and Tolerability of Acthar in Patients With Amyotrophic Lateral Sclerosis | Interventional | Phase 2 | Not recruiting | p_2 os_nte st_int country_United States state_Alabama state_Arizona state_California state_Florida state_Georgia state_Kansas state_Minnesota state_Nebraska state_Pennsylvania state_Tennessee state_Texas NCT01906658 |
Electrical Impedance Myography: Natural History Studies in Neuromuscular Disorders and Healthy Volunteers | Interventional | N/A | Recruiting | p_NA os_enr p_Oint st_int National Institutes of Health Clinical Center state_Maryland country_United States NCT01900132 |
A Novel Immunosuppression Intervention for the Treatment of Amyotrophic Lateral Sclerosis (ALS)![]() | Interventional | Phase 2 | Not recruiting | p_2 os_nte _NAT st_int Massachusetts General Hospital state_Massachusetts country_United States state_Georgia NCT01884571 |
Efficacy, Safety and Tolerability Study of 1 mg Rasagiline in Patients With Amyotrophic Lateral Sclerosis (ALS) Receiving Standard Therapy (Riluzole) - An AMG Trial With a Market Authorized Substance | Interventional | Phase 2 | Not recruiting | p_2 os_nte st_int University of Ulm country_United States state_Baden-Württemberg country_Germany state_Bayern state_Hessen state_Mecklenburg-Vorpommern state_Niedersachsen state_Nordrhein-Westfalen state_Nordrhrein-Westfalen state_Sachsen-Anhalt state_Sachsen state_Thueringen NCT01879241 |
GM604 Phase 2A Randomized Double-blind Placebo Controlled Pilot Trial in Amyotrophic Lateral Disease (ALS) | Interventional | Phase 2 | Not recruiting | p_2 os_nte st_int Genervon Biopharmaceuticals, LLC country_United States state_Massachusetts state_New York NCT01854294 |
A Safety and Tolerability Study of Mexiletine in Patients With Sporadic Amyotrophic Lateral Sclerosis (SALS)![]() | Interventional | Phase 2 | Not recruiting | p_2 os_nte _NAT st_int Mass General state_Massachusetts country_United States state_California state_Iowa state_Kansas state_Missouri state_New York state_Pennsylvania state_Texas state_Washington NCT01849770 |
Determining the Safety of L-Serine in Subjects With Amyotrophic Lateral Sclerois (ALS) at Varied Doses. | Interventional | Phase 1/Phase 2 | Not recruiting | p_1 p_2 os_nte p_Oint st_int Phoenix Neurological Associates country_United States state_Arizona state_California NCT01835782 |
Mexiletine for the Treatment of Muscle Cramps in ALS | Interventional | Phase 4 | Not recruiting | p_4 os_nte p_Oint st_int University of California, Davis state_California country_United States NCT01811355 |
The Experimental Treatment of Bulbar Dysfunction in Amyotrophic Lateral Sclerosis (ALS)![]() | Interventional | Phase 2 | Not recruiting | p_2 os_nte _NAT st_int Massachusetts General Hospital state_Massachusetts country_United States state_California state_District of Columbia state_Michigan state_Minnesota state_Nebraska state_Ohio state_Oregon NCT01806857 |
Noninvasive Assessment of Neuromuscular Disease Using Electrical Impedance Myography | Observational | N/A | Not recruiting | os_nte p_Oint st_obs Convergence Medical Devices state_Massachusetts country_United States NCT01803386 |
Phase 2 Study of Rasagiline for Treatment of Amyotrophic Lateral Sclerosis | Interventional | Phase 2 | Not recruiting | p_2 os_nte st_int University of Kansas state_Kansas country_United States state_Arizona state_California state_Missouri state_Nebraska state_New York state_Oregon state_Pennsylvania state_Texas NCT01786603 |
Ultrasonography in Amyotrophic Lateral Sclerosis as a Predictor of Disease Progression and Tool in Diagnosis: a Pilot Study | Observational | N/A | Not recruiting | os_nte p_Oint st_obs Duke University Medical Center state_North Carolina country_United States NCT01785550 |
Phase IIa Double-Blind, Placebo-Controlled Study to Evaluate the Safety of Oral Fingolimod in Patients With Amyotrophic Lateral Sclerosis (ALS)![]() | Interventional | Phase 2 | Not recruiting | p_2 os_nte _NAT st_int Massachusetts General Hospital state_Massachusetts country_United States state_California state_Georgia state_Texas NCT01786174 |
A Phase IIa, Open Label, Dose-escalating Clinical Study to Evaluate the Safety, Tolerability and Therapeutic Effects of Transplantation of Autologous Mesenchymal Bone Marrow Stromal Cells Secreting Neurotrophic Factors (MSC-NTF), in Patients With Amyotrophic Lateral Sclerosis (ALS). | Interventional | Phase 2 | Not recruiting | p_2 os_nte st_int Hadassah Medical Organization country_United States country_Israel NCT01777646 |
A Fase II, Randomized, Double-Blind, Placebo-Controlled, Multicentre Study for the Safety and Efficacy on Spasticity Symptoms of a Cannabis Sativa Extract in Motor Neuron Disease Patients | Interventional | Phase 2/Phase 3 | Not recruiting | p_2 p_3 os_nte st_int San Raffaele Scientific Institute country_United States country_Italy NCT01776970 |
The National Amyotrophic Lateral Sclerosis Registry | Observational [Patient Registry] | N/A | Recruiting | os_enr p_Oint st_obs CDC state_Georgia country_United States NCT01772602 |
Study NOG112264, a Phase II Study of Ozanezumab (GSK1223249) Versus Placebo in the Treatment of Amyotrophic Lateral Sclerosis | Interventional | Phase 2 | Not recruiting | p_2 os_nte st_int country_United States state_Massachusetts state_Michigan state_New York state_Ohio state_New South Wales country_Australia state_Queensland country_Belgium state_Alberta country_Canada state_Ontario state_Quebec country_France state_Baden-Wuerttemberg country_Germany state_Bayern state_Niedersachsen state_Nordrhein-Westfalen state_Thueringen state_Piemonte country_Italy state_Veneto country_Japan country_Korea, Republic of country_Netherlands state_Lancashire country_United Kingdom NCT01753076 |
Initiation of Long-term Home Non-invasive Ventilation in Amyotrophic Lateral Sclerosis (ALS) Using the iVAPS Mode During a Daytime Trial | Interventional | N/A | Not recruiting | p_NA os_nte p_Oint st_int Montreal Chest Institute country_United States state_Quebec country_Canada NCT01746381 |
A Phase II, Open-label, Dose Escalation and Safety Study of Human Spinal Cord Derived Neural Stem Cell Transplantation for the Treatment of Amyotrophic Lateral Sclerosis![]() | Interventional | Phase 2 | Not recruiting | p_2 os_nte _NAT st_int Emory University state_Georgia country_United States state_Massachusetts state_Michigan NCT01730716 |
A Phase IIb, Multi-National, Double-Blind, Randomized, Placebo-Controlled Study to Evaluate the Safety, Tolerability and Efficacy of CK-2017357 in Patients With Amyotrophic Lateral Sclerosis (ALS) (BENEFIT-ALS)![]() | Interventional | Phase 2 | Not recruiting | p_2 os_nte _NAT st_int country_United States state_Arizona state_California state_Connecticut state_District of Columbia state_Florida state_Georgia state_Indiana state_Iowa state_Kansas state_Maryland state_Massachusetts state_Michigan state_Minnesota state_Missouri state_Nebraska state_New Hampshire state_New York state_North Carolina state_Ohio state_Oregon state_Pennsylvania state_Tennessee state_Texas state_Virginia state_West Virginia state_Wisconsin state_Alberta country_Canada state_British Columbia state_New Brunswick state_Nova Scotia state_Ontario state_Quebec country_France country_Germany country_Ireland country_Netherlands country_Spain state_London country_United Kingdom NCT01709149 |
DNA, Blood and Skin Cell Repository for Research on ALS and Related Neurodegenerative Disorders at Mayo Clinic Florida | Observational | N/A | Not recruiting | os_nte p_Oint st_obs Mayo Clinic Florida state_Florida country_United States NCT01699451 |
Intra-spinal Cord Delivery of Human Neural Stem Cells in ALS Patients: Proposal for a Phase I Study/ Trapianto Intramidollare di Cellule Staminali Neurali Umane Come Terapia Putativa Per la SLA: Proposta di un Trial Clinico di Fase I | Interventional | Phase 1 | Not recruiting | p_1 os_nte p_Oint st_int Azienda Ospedaliera Santa Maria country_United States country_Italy NCT01640067 |
A Dose-escalation Safety Trial for Intrathecal Autologous Mesenchymal Stem Cell Therapy in Amyotrophic Lateral Sclerosis | Interventional | Phase 1 | Not recruiting | p_1 os_nte p_Oint st_int Mayo Clinic state_Minnesota country_United States NCT01609283 |
HDE Post-Approval Study (PAS) of NeuRx DPS for ALS | Interventional | N/A | Not recruiting | p_NA os_nte p_Oint st_int California Pacific Medical Center -- Forbes Norris MDA/ALS Research Center state_California country_United States state_Colorado state_Florida state_Illinois state_Kansas state_Nebraska state_New York state_North Carolina state_Ohio state_Oregon NCT01605006 |
A Multi-Center Longitudinal Biorepository Study to Provide Biospecimens & Clinical Data From Neurological Disease Patients To Approved Pre-Clinical And Clinical Investigators for Drug & Biomarker Studies | Observational | N/A | Not recruiting | os_nte p_Oint st_obs Sanguine Biosciences state_California country_United States NCT01592552 |
Cohort Study of the Relationship of Hyperlipidemia and Statin Therapy on Survival and Disease Progresssion in Amyotrophic Lateral Sclerosis | Observational | N/A | Not recruiting | os_nte p_Oint st_obs Methodist Neurological Institute state_Texas country_United States NCT01592084 |
Randomized Double Blind Placebo Controlled Cross-Over Study of Incobotulinum Toxin A (Xeomin®) for Troublesome Sialorrhea in Parkinson's Disease (PD)/Parkinsonism and Amyotrophic Lateral Sclerosis (ALS) | Interventional | Phase 2 | Not recruiting | p_2 os_nte st_int Beth Israel Deaconess Medical Center state_Massachusetts country_United States NCT01565395 |
An Open-Label Study to Assess the Effect of Cimetidine on the Pharmacokinetics of Dexpramipexole (BIIB050) in Healthy Volunteers | Interventional | Phase 1 | Not recruiting | p_1 os_nte p_Oint st_int Research Site state_Kansas country_United States NCT01536249 |
Trial of Resistance and Endurance Exercise in Amyotrophic Lateral Sclerosis (ALS)![]() | Interventional | N/A | Not recruiting | p_NA os_nte _NAT p_Oint st_int Johns Hopkins University state_Maryland country_United States state_California state_Massachusetts state_North Carolina NCT01521728 |
A Single-Center, Randomized, Blinded, Placebo- and Active-Controlled Crossover Study to Evaluate the Effect of Dexpramipexole (BIIB050) on the QTc Interval in Healthy Volunteers | Interventional | Phase 1 | Not recruiting | p_1 os_nte p_Oint st_int Research Site state_Kansas country_United States NCT01511029 |
PRE-Symptomatic Studies in Amyotrophic Lateral Sclerosis | Observational | N/A | Not recruiting | os_nte p_Oint st_obs University of Miami state_Florida country_United States NCT01508962 |
A Multicenter Study for the Discovery and Validation of ALS Biomarkers![]() | Observational | N/A | Not recruiting | os_nte _NAT p_Oint st_obs Mass General Hospital state_Massachusetts country_United States state_Arizona state_Florida state_Georgia state_Pennsylvania NCT01495390 |
Efficacy and Safety Study of MCI-186 for Treatment of the Patients With Amyotrophic Lateral Sclerosis (ALS) 2 | Interventional | Phase 3 | Not recruiting | p_3 os_nte st_int country_Japan NCT01492686 |
A Phase II, Multicenter, Double-Blind, Randomized, Placebo-Controlled Dose Titration Study to Evaluate the Safety, Tolerability and Pharmacodynamic Effects of CK-2017357 in Patients With Amyotrophic Lateral Sclerosis (ALS) | Interventional | Phase 2 | Not recruiting | p_2 os_nte st_int Cytokinetics state_California country_United States state_Connecticut state_Massachusetts state_Missouri state_New York state_North Carolina state_Ohio state_Oregon state_Texas NCT01486849 |
Family Studies in Neuromuscular Disorders | Observational | N/A | Recruiting | os_enr p_Oint st_obs University of Massachusetts Medical School state_Massachusetts country_United States NCT01459302 |
A Randomized, Blinded, Placebo-Controlled Ascending Dose Study of the Safety and Pharmacokinetics of Dexpramipexole in Healthy Volunteers | Interventional | Phase 1 | Not recruiting | p_1 os_nte p_Oint st_int Research Site state_Kansas country_United States NCT01449578 |
A Phase II, Double-Blind, Randomized, Placebo-Controlled Study to Evaluate the Effects of Multiple Doses of CK-2017357 in Patients With Amyotrophic Lateral Sclerosis (ALS) | Interventional | Phase 2 | Not recruiting | p_2 os_nte st_int Cytokinetics state_California country_United States state_Florida state_Kansas state_Maryland state_New York state_North Carolina state_Pennsylvania NCT01378676 |
PRISM Registry: Pseudobulbar Affect Registry Series | Observational | N/A | Not recruiting | os_nte p_Oint st_obs Avanir Pharmaceuticals state_California country_United States NCT01366027 |
Progression of Respiratory Dysfunction in Amyotrophic Lateral Sclerosis (ALS) Patients: A Comparison of Standard of Practice vs Polysomnography-Directed Nocturnal Non-Invasive Positive Pressure Ventilation | Interventional | N/A | Not recruiting | p_NA os_nte p_Oint st_int Columbia University Medical Center state_New York country_United States NCT01363882 |
A Phase l, Open-label, First in Human, Feasibility and Safety Study of Human Spinal Cord Derived Neural Stem Cell Transplantation for the Treatment of Amyotrophic Lateral Sclerosis![]() | Interventional | Phase 1 | Not recruiting | p_1 os_nte _NAT p_Oint st_int Massachusetts General Hospital state_Massachusetts country_United States state_Georgia NCT01348451 |
A Phase 2 Randomized, Double-Blind, Placebo-Controlled, Multicenter Study of NP001 in Subjects With Amyotrophic Lateral Sclerosis (ALS) | Interventional | Phase 2 | Not recruiting | p_2 os_nte st_int Forbes Norris ALS Treatment and Research, California Pacific Medical Center state_California country_United States state_Arizona state_Florida state_Georgia state_Kansas state_Kentucky state_Massachusetts state_New York state_North Carolina state_Ohio state_Oregon state_Texas state_Washington NCT01281631 |
A Randomized, Double-Blind, Placebo-Controlled, Multi-Center Study of the Safety and Efficacy of Dexpramipexole in Subjects With Amyotrophic Lateral Sclerosis![]() | Interventional | Phase 3 | Not recruiting | p_3 os_nte _NAT st_int Biogen Idec country_United States state_Arizona state_Arkansas state_California state_Connecticut state_Florida state_Georgia state_Illinois state_Indiana state_Iowa state_Kansas state_Maryland state_Massachusetts state_Michigan state_Minnesota state_Missouri state_Nebraska state_Nevada state_New Hampshire state_New York state_North Carolina state_Ohio state_Oregon state_Pennsylvania state_Tennessee state_Texas state_Utah state_Virginia state_Washington state_New South Wales country_Australia state_Queensland state_Victoria country_Belgium state_Alberta country_Canada state_Quebec country_France country_Germany country_Ireland country_Netherlands country_Spain country_Sweden country_United Kingdom NCT01281189 |
Phase 1 Open Label Study of Zinc Therapy in ALS Patients | Interventional | Phase 1/Phase 2 | Not recruiting | p_1 p_2 os_nte p_Oint st_int Phoenix Neurological Associates state_Arizona country_United States NCT01259050 |
Phase 2 Selection Trial of High Dosage Creatine and Two Dosages of Tamoxifen in Amyotrophic Lateral Sclerosis (ALS)![]() | Interventional | Phase 2 | Not recruiting | p_2 os_nte _NAT st_int country_United States state_Kansas state_Massachusetts state_Missouri state_New York state_North Carolina state_Pennsylvania state_Washington state_Wisconsin NCT01257581 |
A Multi-Center Controlled Screening Trial of Safety and Efficacy of Rasagiline in Subjects With Amyotrophic Lateral Sclerosis (ALS) | Interventional | Phase 2 | Not recruiting | p_2 os_nte st_int University of Kansas state_Kansas country_United States state_Arizona state_California state_Iowa state_Minnesota state_Nebraska state_Pennsylvania state_Tennessee state_Texas state_Quebec country_Canada NCT01232738 |
Trial of Ascertaining Individual Preferences for Loved One's Role in End-of-Life | Interventional | N/A | Not recruiting | p_NA os_nte p_Oint st_int Johns Hopkins University state_Maryland country_United States NCT01160367 |
A Randomized Crossover Study of Standard, Noninvasive Positive Pressure Ventilation (NIPPV) and Low Expiratory Pressure NIPPV in Amyotrophic Lateral Sclerosis (ALS) Patients | Interventional | N/A | Not recruiting | p_NA os_nte p_Oint st_int University of Michigan state_Michigan country_United States NCT01154283 |
Oxidative Stress in Motor Neuron Disease: COSMOS-PLS Add-On Study | Observational | N/A | Not recruiting | os_nte p_Oint st_obs National Institutes of Health Clinical Center state_Maryland country_United States NCT01143428 |
A Single Patient Treatment Protocol for Autologous Mesenchymal Stem Cell Intraspinal Therapy in Amyotrophic Lateral Sclerosis (ALS) | Interventional | Phase 1 | Not recruiting | p_1 os_nte p_Oint st_int Mayo Clinic state_Minnesota country_United States NCT01142856 |
A P300 Brain Computer Interface to Operate Power Wheelchair Tilt | Interventional | N/A | Not recruiting | p_NA os_nte p_Oint st_int University of Michigan state_Michigan country_United States NCT01123148 |
An In-home Study of Brain Computer Interfaces | Interventional | N/A | Not recruiting | p_NA os_nte p_Oint st_int University of Michigan state_Michigan country_United States NCT01123200 |
A Phase II, Double-Blind, Randomized, Placebo-Controlled, Three-Way Crossover, Pharmacokinetic and Pharmacodynamic Study of CK-2017357 in Patients With Amyotrophic Lateral Sclerosis (ALS)![]() | Interventional | Phase 2 | Not recruiting | p_2 os_nte _NAT st_int State University of New York - Upstate Medical University state_New York country_United States state_Arizona state_California state_Florida state_Kentucky state_Maryland state_Massachusetts state_Missouri state_North Carolina state_Oregon state_Pennsylvania state_Texas state_Vermont NCT01089010 |
Phase I/II Study of SOD1 Inhibition by Pyrimethamine in Familial ALS | Interventional | Phase 1/Phase 2 | Not recruiting | p_1 p_2 os_nte p_Oint st_int Weill Medical College of Cornell University state_New York country_United States state_Texas country_Germany country_Italy country_Sweden NCT01083667 |
Phase I, Single Center, Prospective, Non-randomized, Open Label, Safety/Efficacy Study of the Infusion of Autologous Bone Marrow-derived Stem Cells, in Patients With Amyotrophic Lateral Sclerosis | Interventional | Phase 1 | Not recruiting | p_1 os_nte p_Oint st_int TCA Cellular Therapy state_Louisiana country_United States NCT01082653 |
A Phase I/II, Open Label Study to Evaluate Safety, Tolerability and Therapeutic Effects of Transplantation of Autologous Cultured Mesenchymal Bone Marrow Stromal Cells Secreting Neurotrophic Factors (MSC-NTF), in ALS Patients. | Interventional | Phase 1/Phase 2 | Not recruiting | p_1 p_2 os_nte p_Oint st_int Hadassah University Hospital country_United States country_Israel NCT01051882 |
A Phase 1, Double-Blind, Placebo-Controlled, Dose-Escalation Study of the Safety, Tolerability, and Pharmacokinetics of ISIS 333611 Administered Intrathecally to Patients With Familial Amyotrophic Lateral Sclerosis Due to Superoxide Dismutase 1 Gene Mutations![]() | Interventional | Phase 1 | Not recruiting | p_1 os_nte _NAT p_Oint st_int Massachusetts General Hospital state_Massachusetts country_United States state_Maryland state_Missouri state_Texas NCT01041222 |
Safety and Tolerability of the Ketogenic Diet in ALS | Interventional | Phase 3 | Not recruiting | p_3 os_nte st_int Johns Hopkins ALS Clinic state_Maryland country_United States NCT01016522 |
Phase II Safety and Tolerability Study of High Fat/High Calorie Versus High Calorie Versus Optimal Nutrition in Subjects With Amyotrophic Lateral Sclerosis![]() | Interventional | Phase 2 | Not recruiting | p_2 os_nte _NAT st_int Massachusetts General Hospital state_Massachusetts country_United States state_Arizona state_California state_Florida state_Georgia state_Michigan state_New York state_North Carolina state_Oregon state_Pennsylvania state_Texas state_Vermont NCT00983983 |
Supported Treadmill Ambulation Training (STAT) for Patients Diagnosed With Amyotrophic Lateral Aclerosis | Interventional | Phase 1/Phase 2 | Not recruiting | p_1 p_2 os_nte p_Oint st_int Carolinas ALS Clinical Resarch Center state_North Carolina country_United States NCT00956488 |
Assessment of Postural Orientation and Equilibrium In Early Amyotrophic Lateral Sclerosis (ALS) | Observational | N/A | Not recruiting | os_nte p_Oint st_obs Carolinas ALS Clinical Research Center state_North Carolina country_United States NCT00956501 |
An Open-Label, Safety and Tolerability, Study Evaluating KNS-760704 in Patients With Amyotrophic Lateral Sclerosis (ALS)![]() | Interventional | Phase 2 | Not recruiting | p_2 os_nte _NAT st_int MGH NCRI state_Massachusetts country_United States state_Arkansas state_California state_Florida state_Kansas state_Maryland state_Missouri state_Nebraska state_New York state_Pennsylvania state_Tennessee state_Texas state_Utah state_Virginia state_Washington NCT00931944 |
Phase IIA Trial: Tretinoin and Pioglitazone HCL Combination Therapy in Amyotrophic Lateral Sclerosis | Interventional | Phase 1/Phase 2 | Not recruiting | p_1 p_2 os_nte p_Oint st_int Phoenix Neurological Associates, LTD state_Arizona country_United States NCT00919555 |
BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Tetraplegia | Interventional | N/A | Recruiting | p_NA os_enr p_Oint st_int Massachusetts General Hospital state_Massachusetts country_United States state_California state_Georgia state_Rhode Island NCT00912041 |
A Randomized, Double-blind Multicenter Pilot Study vs. Placebo for the Evaluation of Efficacy and Tolerability of Tauroursodeoxycholic Acid Administered by Oral Route as Add on Treatment in Patients Affected by Amyotrophic Lateral Sclerosis | Interventional | Phase 2 | Not recruiting | p_2 os_nte st_int Fondazione IRCCS Istituto neurologico Carlo Besta country_Italy NCT00877604 |
A Single and Repeat Dose Escalation Study of the Safety, Pharmacokinetics and Pharmacodynamics of GSK1223249 in ALS Patients | Interventional | Phase 1 | Not recruiting | p_1 os_nte p_Oint st_int country_United States state_Maryland state_New York state_North Carolina state_Ohio country_France state_Veneto country_Italy country_United Kingdom NCT00875446 |
Identification of Genes Causing Familial ALS or Increasing Risk for Sporadic ALS and ALS With Frontotemporal Dementia and Understanding Disease Mechanism. | Observational | N/A | Not recruiting | os_nte p_Oint st_obs Northwestern University Feinberg School of Medicine state_Illinois country_United States NCT00821132 |
A Multicenter, Double-Blind, Placebo-Controlled, Study to Investigate the Safety and Efficacy of Lithium in Combination With Riluzole in Volunteers With Amyotrophic Lateral Sclerosis (ALS)![]() | Interventional | Phase 2/Phase 3 | Not recruiting | p_2 p_3 os_nte _NAT st_int Massachusetts General Hospital state_Massachusetts country_United States state_Arizona state_California state_Florida state_Indiana state_Kentucky state_Maryland state_Michigan state_Minnesota state_Missouri state_New York state_North Carolina state_Ohio state_Pennsylvania state_Texas state_Vermont state_Virginia state_Alberta country_Canada state_British Columbia state_Manitoba state_New Brunswick state_Nova Scotia state_Ontario state_Quebec state_Saskatchewan NCT00818389 |
Derivation of Induced Pluripotent Stem Cells From an Existing Collection of Human Somatic Cells | Observational | N/A | Recruiting | os_enr st_obs country_Israel NCT00801333 |
Cooperative Studies Program (CSP) #567 - A Clinical Demonstration of EEG Brain-computer Interface for ALS Patients | Observational | N/A | Not recruiting | os_nte p_Oint st_obs Office of Veterans Affairs state_Ohio country_United States state_Connecticut state_New York state_North Carolina state_Rhode Island NCT00786032 |
A Phase 2 Repeat-Dosing Clinical Trial of SB-509 in Subjects With Amyotrophic Lateral Sclerosis | Interventional | Phase 2 | Not recruiting | p_2 os_nte st_int Sangamo Biosciences, Inc. state_California country_United States state_Kansas state_Maryland state_Texas NCT00748501 |
Comparing The Cyberlink Control System to the Manual Letter Board for Communication Purposes in the ALS Patient Population | Observational | N/A | Not recruiting | os_nte p_Oint st_obs MDA/ALS Center of Hope state_Pennsylvania country_United States NCT00718497 |
Assessment of the Cyberlink Control System for Use by the ALS Patient | Observational | N/A | Not recruiting | os_nte p_Oint st_obs MDA/ALS Center of Hope state_Pennsylvania country_United States NCT00718016 |
Satisfaction Survey for ALS Patients Comparing Rooms With and Without Assistive Technology | Observational | N/A | Not recruiting | os_nte p_Oint st_obs MDA/ALS Center of Hope state_Pennsylvania country_United States NCT00718107 |
Noninvasive Examination of the Work of Breathing in Patients With Amyotrophic Lateral Sclerosis (ALS). | Observational | N/A | Not recruiting | os_nte p_Oint st_obs MDA/ALS Center of Hope state_Pennsylvania country_United States NCT00718003 |
EEG-Based Brain-Computer Interface Project for Individuals With ALS | Observational | N/A | Not recruiting | os_nte p_Oint st_obs MDA/ALS Center of Hope state_Pennsylvania country_United States NCT00718458 |
ALS Tissue Donation Program | Observational | N/A | Not recruiting | os_nte p_Oint st_obs MDA/ALS Center of Hope state_Pennsylvania country_United States NCT00716131 |
Quantitative Measurement of Nutritional Substrate Utilization in Patients With ALS | Observational | N/A | Not recruiting | os_nte p_Oint st_obs MDA/ALS Center of Hope state_Pennsylvania country_United States NCT00714220 |
Non-Invasive Measurement of GI Motility in Patients With ALS | Observational | N/A | Not recruiting | os_nte p_Oint st_obs MDA/ALS Center of Hope state_Pennsylvania country_United States NCT00714805 |
Phase II/III Randomized, Placebo-Controlled Trial of Arimoclomol in SOD1 Positive Familial Amyotrophic Lateral Sclerosis (ALS)![]() | Interventional | Phase 2/Phase 3 | Not recruiting | p_2 p_3 os_nte _NAT st_int University of Miami state_Florida country_United States state_Massachusetts NCT00706147 |
A Multicenter Study for the Validation of ALS Biomarkers![]() | Observational | N/A | Not recruiting | os_nte _NAT p_Oint st_obs NCRI at the Massachusetts General Hospital state_Massachusetts country_United States state_Arizona state_California state_Florida state_Georgia state_Illinois state_Maryland state_Michigan state_Minnesota state_Missouri state_New Hampshire state_New Jersey state_New York state_North Carolina state_Ohio state_Oregon state_Pennsylvania state_Texas state_Utah state_Quebec country_Canada NCT00677768 |
Electrical Impedance Myography as an Outcome Measure in ALS Clinical Trials | Observational | N/A | Not recruiting | os_nte p_Oint st_obs Beth Israel Deaconess Medical Center state_Massachusetts country_United States state_Florida state_Georgia state_Maryland state_New York state_North Carolina state_Virginia NCT00620698 |
Validation of a New Device to Measure Neuromuscular Disease Progression![]() | Observational | N/A | Not recruiting | os_nte _NAT p_Oint st_obs Massachusetts General Hospital - East state_Massachusetts country_United States NCT00606918 |
University of Wisconsin-Madison: Wisconsin Brain Donor Program (WBDP) | Observational | N/A | Recruiting | os_enr p_Oint st_obs University of Wisconsin Madison state_Wisconsin country_United States NCT00585572 |
Pilot Placebo-Controlled Trial of Early Noninvasive Ventilation for ALS | Interventional | Phase 1 | Not recruiting | p_1 os_nte p_Oint st_int University of Michigan state_Michigan country_United States NCT00580593 |
Effect of Noninvasive Positive Pressure Ventilation on Pulmonary Function Testing in Amyotrophic Lateral Sclerosis | Interventional | N/A | Not recruiting | p_NA os_nte p_Oint st_int Columbia University state_New York country_United States NCT00537446 |
A Phase II/III Study in Patients With Amyotrophic Lateral Sclerosis (ALS) | Interventional | Phase 2/Phase 3 | Not recruiting | p_2 p_3 os_nte st_int country_Japan state_Aichi state_Akita state_Aomori state_Chiba state_Ehime state_Fukuoka state_Fukushima state_Gunma state_Hiroshima state_Hokkaido state_Ishikawa state_Iwate state_Kanagawa state_Kochi state_Kyoto state_Mie state_Miyagi state_Nagano state_Nagasaki state_Niigata state_Okayama state_Okinawa state_Osaka state_Saitama state_Shiga state_Shizuoka state_Tochigi state_Tokushima state_Tokyo state_Wakayama state_Yamagata state_Yamaguchi NCT00444613 |
A Long-Term Study in Patients With Amyotrophic Lateral Sclerosis (ALS) | Interventional | Phase 2/Phase 3 | Not recruiting | p_2 p_3 os_nte st_int country_United States state_Aichi country_Japan state_Aomori state_Chiba state_Ehime state_Fukuoka state_Fukushima state_Gunma state_Hiroshima state_Hokkaido state_Ishikawa state_Iwate state_Kanagawa state_Kochi state_Kyoto state_Mie state_Miyagi state_Nagano state_Nagasaki state_Niigata state_Okayama state_Okinawa state_Osaka state_Saitama state_Shizuoka state_Tochigi state_Tokushima state_Tokyo state_Wakayama state_Yamagata state_Yamaguchi NCT00445172 |
Collection of Blood Samples for DNA Analysis in Motor Neuron Diseases | Observational | N/A | Not recruiting | os_nte p_Oint st_obs National Institutes of Health Clinical Center state_Maryland country_United States NCT00362362 |
Clinical Trial Ceftriaxone in Subjects With Amyotrophic Lateral Sclerosis (ALS)![]() | Interventional | Phase 3 | Not recruiting | p_3 os_nte _NAT st_int Massachusetts General Hospital state_Massachusetts country_United States state_Arizona state_California state_Colorado state_Connecticut state_District of Columbia state_Florida state_Georgia state_Illinois state_Indiana state_Kansas state_Kentucky state_Michigan state_Minnesota state_Missouri state_Nebraska state_New Jersey state_New York state_North Carolina state_Ohio state_Oregon state_Pennsylvania state_South Carolina state_Tennessee state_Texas state_Utah state_Virginia state_Alberta country_Canada state_Nova Scotia state_Ontario state_Quebec NCT00349622 |
Cortical Function in Primary Lateral Sclerosis and Amyotrophic Lateral Sclerosis | Observational | N/A | Not recruiting | os_nte p_Oint st_obs National Institutes of Health Clinical Center state_Maryland country_United States NCT00334516 |
The Pre-symptomatic Familial Amyotrophic Lateral Sclerosis (Pre-fALS) Study![]() | Observational | N/A | Recruiting | os_enr _NAT p_Oint st_obs University of Miami Miller School of Medicine state_Florida country_United States NCT00317616 |
A Multicenter, Dose Ranging Safety and Pharmacokinetics Study of Arimoclomol in Amyotrophic Lateral Sclerosis (ALS)![]() | Interventional | Phase 2 | Not recruiting | p_2 os_nte _NAT st_int country_United States state_California state_Florida state_Kansas state_Massachusetts state_Minnesota state_New York state_North Carolina state_Pennsylvania state_Texas NCT00244244 |
Clinical Research in Amyotrophic Lateral Sclerosis | Observational | N/A | Recruiting | os_enr p_Oint st_obs University of Miami Miller School of Medicine state_Florida country_United States NCT00136500 CRiALS |
A Randomized, Double-Blind, Placebo-Controlled Study of Safety and Efficacy of Botulinum Toxin Type B (Myobloc) in Sialorrhea in Amyotrophic Lateral Sclerosis | Interventional | Phase 2/Phase 3 | Not recruiting | p_2 p_3 os_nte st_int country_United States state_Kansas state_North Carolina NCT00125203 |
Safety and Dose Escalating Study of Oral Sodium Phenylbutyrate in Subjects With Amyotrophic Lateral Sclerosis | Interventional | Phase 1/Phase 2 | Not recruiting | p_1 p_2 os_nte p_Oint st_int country_United States state_Iowa state_Kentucky state_Maryland state_Massachusetts state_New York state_North Carolina state_Ohio state_Pennsylvania state_Texas NCT00107770 |
Nuclear Magnetic Spectroscopy for the Evaluation of Primary Lateral Sclerosis, Hereditary Spastic Paraplegia and Amyotrophic Lateral Sclerosis | Observational | N/A | Not recruiting | os_nte p_Oint st_obs National Institute of Neurological Disorders and Stroke state_Maryland country_United States NCT00023075 |
Screening and Natural History: Primary Lateral Sclerosis and Related Disorders | Observational | N/A | Not recruiting | os_nte p_Oint st_obs National Institutes of Health Clinical Center state_Maryland country_United States NCT00015444 |
Clinical and Molecular Manifestations of Inherited Neurological Disorders | Observational | N/A | Recruiting | os_enr p_Oint st_obs National Institutes of Health Clinical Center state_Maryland country_United States NCT00004568 | Trial Name | Study Type | Phase | Status | KEY |
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