NEALS Central Institutional Review Board (cIRB)

Overview of the Central IRB

The central Institutional Review Board (cIRB) for selected NEALS clinical trials is the Mass General Brigham Human Research Committee, located in Boston, MA. It is the same cIRB that oversees all studies conducted by the NeuroNEXT Network (www.neuronext.org). Sites that participate in studies that utilize the NEALS cIRB must have an executed cIRB Authorization Agreement also called a Reliance Agreement (RA) to rely on the Mass General Brigham IRB. Signing the NEALS RA does not preclude a site from participating in any other IRB authorization agreements that it may have or entered with other entities. For each study that utilizes the NEALS cIRB, sites are asked to confirm that their institution agrees to rely on the cIRB (via the terms of the agreed upon RA), with an option to opt out of participation in any study if their institution does not agree.

If your site is interested in executing a Reliance Agreement with the Mass General Brigham, please contact Catherine Gladden, the cIRB Liaison Regulatory Manager, at email hidden; JavaScript is required.

List of Participating NEALS Sites with an Executed Reliance Agreement

Current as of June 2022

ALS Center at the Swedish Neuroscience Institute
Atrium Health
Augusta University
Barrow Neurological Institute
Beth Israel Deaconess Medical Center
Brigham and Women’s Hospital
California Pacific Medical Center
Cedars-Sinai Medical Center
Cleveland Clinic
Columbia University Medical Center
Dartmouth-Hitchcock
Drexel University
Duke University Medical Center
Emory University
Essentia Health
George Washington University
Georgetown University
Hackensack Meridian Health
Henry Ford Hospital
Holy Cross Hospital
Hospital for Special Care
Indiana University
Jefferson Weinberg ALS Center
Johns Hopkins University
Kaiser Permanente
Lahey Clinic
Las Vegas Clinic
Lehigh Valley Hospital
Loma Linda University
Massachusetts General Hospital
Mayo Clinic (includes Jacksonville, Phoenix, and Rochester)
Medical College of Wisconsin
Medical University of South Carolina
Methodist Neurological Institute
Minneapolis Medical Research Foundation
Mount Sinai Beth Israel
Neurology Associates
Neuromuscular Research Center
Northwestern University
Nova Southeastern University
Ochsner Neuroscience Institute
Ohio Health
Ohio State University
Oregon Health & Science University
Penn State University School of Medicine
Providence ALS Center, Portland, OR
Saint Alphonsus Regional Medical Center
Saint Louis University
Spectrum Health Medical Group
St. Luke’s Rehabilitation Institute
SUNY at Stony Brook
SUNY Upstate Medical Center
Temple University
Texas Neurology, P.A.
Twin Cities ALS Research Consortium
University of Arkansas for Medical Sciences
University of California, Davis
University of California, Irvine
University of California, Los Angeles
University of California, San Francisco
University of Chicago
University of Cincinnati
University of Colorado
University of Florida, Gainesville
University of Florida, Jacksonville
University of Iowa
University of Kansas Medical Center
University of Kentucky
University of Maryland
University of Massachusetts Medical School
University of Miami
University of Michigan
University of Minnesota
University of Missouri
University of Nebraska Medical Center
University of Pennsylvania
University of Pittsburgh
University of South Florida
University of Southern California
University of Texas Health Science Center, San Antonio
University of Utah
University of Virginia
University of Washington
Vanderbilt University Medical Center
Virginia Commonwealth University
Wake Forest University Health Sciences
Washington University in St. Louis
Wesley Neurology Clinic
Yale University

Resources for Sites:

Webinars:

NEALS Central IRB (cIRB) Model Webinar
September 12, 2016
This webinar was presented by the NEALS Central IRB. Covered in this webinar were general comments on central IRBs, a brief overview of the NEALS cIRB model, and a discussion on the NEALS Reliance Agreement.

Watch Here

The pilot initiative was made possible by the generous support of The ALS Association.