Feasibility and Sensitivity of a Symptom Monitoring Application in Real Time (SMART) for ALS

Study Purpose:

The purpose of this study is to determine if a smartphone application would be helpful in collecting research data to better inform us about ALS disease progression. This study asks each participant to use a smartphone application for a few minutes each week to answer a questionnaire and complete a voice recording. This is a pilot study in which a smartphone application was designed and customized for use in ALS clinical trials.

Study Status:



Amyotrophic Lateral Sclerosis (ALS) , Familial ALS , Sporadic ALS , Healthy Volunteer , Healthy Volunteer with a Family History of ALS

Study Type:


Type of Intervention:


Intervention Name:






Study Chair(s)/Principal Investigator(s):

James Berry, MD, MPH, Massachusetts General Hospital

Clinicaltrials.gov ID:

Neals Affiliated?


Coordinating Center Contact Information

Massachusetts General Hospital

Alison Clark / email hidden; JavaScript is required / 617-726-4284

55 Fruit Street
Boston, Massachusetts, 02114 United States

Full Study Summary:

Massachusetts General Hospital is seeking individuals to participate in a research study enrolling under the direction of James Berry, MD, MPH. The study is funded by Philanthropy, a NIH Grant, and the Neurological Clinical Research Institute. This study is recruiting adults with Amyotrophic Lateral Sclerosis (ALS) who are smartphone users and are able to download and use a smartphone application. All visits can now be conducted remotely over the phone.

Study Sponsor:

Philanthropy, NIH Grant, and the Neurological Clinical Research Institute

Participant Duration:

1 year

Estimated Study Start Date:

07 / 20 / 2016

Posting Last Modified Date:

12 / 01 / 2022

Date Study Added to neals.org:

12 / 08 / 2016

Minimum Age:


Can participants use Riluzole?


The study is currently recruiting participants who meet the following guideline:

Adults with Amyotrophic Lateral Sclerosis (ALS) and ability to download and use the smartphone application on their smartphone device (iPhone or Android).

Massachusetts General Hospital

Alison Clark / 617-726-4284 / email hidden; JavaScript is required

Amrita Iyer / 617-643-9550 / email hidden; JavaScript is required

Boston, Massachusetts 02114
United States