Study Purpose:The purpose of this study is to determine whether a physiological process known as oxidative stress has any impact on the rate of disease progression in sporadic PLS.
Primary Lateral Sclerosis (PLS)
Type of Intervention:
Study Chair(s)/Principal Investigator(s):
Hiroshi Mitsumoto, MD (Columbia University)
Coordinating Center Contact Information
The Eleanor and Lou Gehrig MDA/ALS Research Center
Jonathan Hupf / (212) 342-0949
710 West 168th Street, NI 9th Floor
New York, New York, 10032 United States
Full Study Summary:
Spastic Paraplegia Foundation
Estimated Study Start Date:
11 / 02 / 2016
Estimated Study Completion Date:
11 / 02 / 2016
Posting Last Modified Date:
01 / 31 / 2016
Date Study Added to neals.org:
08 / 02 / 2012
Diagnosis of definite sporadic PLS.
At least 5 years and no more than 15 years since symptom onset.
Age: 20 years or older.
If the patient has had testing for HSP, the results were normal.
Record of recent EMG done within the last 12 months. If not, patient must be willing to have an EMG done for diagnostic purposes.
Must have a reliable caregiver willing to participate (family member or good friend).
History of any other major neurological problems.
Any other unstable medical diseases that required treatment in the past 6 months.
Participating in any drug trials before baseline specimens collected.
University of Kansas Medical Center
Maureen Walsh / (913) 588- 0645
Kansas City, Kansas
University of Kentucky
Debby Taylor / (859) 257-5560
University of Texas Southwestern
Nina Gorham / (214) 648-0462
Western University London, Ontario
Christine Piechowicz / (519) 685-8500 x34858