Contribution of a Multimodal Digital Platform in the Management and Follow-up of Patients With Amyotrophic Lateral Sclerosis Treated With Non-invasive Ventilation: Randomized Controlled Study

Study Purpose:

The median survival of patients with amyotrophic lateral sclerosis (ALS) is 3 to 5 years and mortality is mainly related to respiratory failure. Non-invasive ventilation (NIV) and multidisciplinary management improve the quality of life and survival of patients. However, patients have mobility difficulties related to the progressive worsening of functional disabilities. The research team hypothesize that the use of a multimodal digital platform, including in particular telemonitoring of NIV and teleconsultation, will slow down the evolution of the disabilities of patients with ALS and improve their quality of life.

Study Status:

Not yet recruiting


Amyotrophic Lateral Sclerosis

Study Type:


Type of Intervention:


Intervention Name:

Telerehabilitation solution (m-Rehab), Usual management including NIV.




Study Chair(s)/Principal Investigator(s):

Francois BUGHIN, MD, University Hospital, Montpellier ID:


Neals Affiliated?


Coordinating Center Contact Information

Francois BUGHIN, MD / email hidden; JavaScript is required /

Full Study Summary:

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease with a median life expectancy of 3 to 5 years. Respiratory failure due to alveolar hypoventilation is the main cause of mortality and respiratory impairment leads to a significant deterioration in quality of life.

Non-invasive ventilation (NIV) improves patient quality of life, improves gas exchange and improves patient survival. NIV should be initiated early, based on symptomatology and lung function, and monitored closely to adjust device parameters. NIV is a complex intervention that must be individualized for each patient.

In addition, multidisciplinary management involving different healthcare professionals, keeping the patient and caregivers at the center of the network, also allows for an improvement in the quality of life and survival of these patients.

However, patients with ALS have difficulty moving around and access to care becomes more complicated as the disease progresses. This phenomenon was increased during the COVID- 19 pandemic with a more rapid functional decline.

The development of new technologies should make it possible to rethink patient management, in particular through remote monitoring of NIV devices, teleconsultation, administration of questionnaires and better interprofessional organization. Several studies have confirmed the feasibility and acceptance of telemedicine solutions in this population.

In this project, The research team hypothesize that the use of a multimodal digital platform will slow the progression of disability in ALS patients and improve their quality of life, in particular by improving the quality of NIV and optimizing the coordination of a multidisciplinary team.

Study Sponsor:

University Hospital, Montpellier

Estimated Enrollment:


Estimated Study Start Date:

05 / 01 / 2023

Estimated Study Completion Date:

05 / 01 / 2025

Posting Last Modified Date:

05 / 01 / 2023

Date Study Added to

05 / 01 / 2023

Minimum Age:

30 Years

Maximum Age:

85 Years

Inclusion Criteria:

- Patients between 30 and 85 years old

- Diagnosis of ALS

- Indication and acceptance of non-invasive ventilation

- Patient equipped with suitable equipment (tablet, computer, telephone, etc.) with an internet connection at home

- Patient able to read and understand the procedure, and able to express consent for the study protocol

Exclusion Criteria:

- Treatment with non-invasive ventilation in the previous three months

- Refusal/inability to use a smart phone or digital device

- Patient currently participating or having participated in the month preceding inclusion in another clinical interventional research that could impact the study, this impact is left to the discretion of the investigator.

- Subject under guardianship or curators

- Subject not affiliated to a social security scheme, or not a beneficiary of such a scheme.

- Subject deprived of liberty by judicial or administrative decision

- Pregnant, parturient, breastfeeding women

- Refusal to give consent

Uh Montpellier

FRANCOIS BUGHIN, MD / Ext. 33 / email hidden; JavaScript is required

Montpellier 34295