Study Purpose:
Amyotrophic lateral sclerosis (ALS) is a serious rapidly progressive disease of the nervous system. The average survival from the time of diagnosis is two to three years. The patient physical and psychological sufferings in ALS are immense, and apart from Riluzole, there is no effective treatment. Care of advanced ALS have an estimated cost of 4-8 million NOK per year. Perhaps the most challenging topic of ALS care is the decision to extend ventilation support into the stages of disease that require treatment both during day and night. In these cases, treatment is clearly life-sustaining and although quality of life may be maintained, the burden of caregiving imposed upon family or health care workers is huge, regardless of tracheostomy (TIV) or non-invasive (NIV) modality.The present study is a longitudinal questionnaire study in Norway measuring overall quality of life, health-related quality of life, and disease-specific quality of life in ALS patients, partners and children before and after the introduction of life sustaining ventilation support. The investigators aim to increase the knowledge on how life-sustaining ventilation support with NIV or TIV affects the quality of life in ALS patients, life partners and children. The results from the study may provide crucial information for clinicians and patients on one of the most difficult ethical issues of ALS treatment. The investigators anticipate that this information will facilitate a shared decision making processes, weighing benefits and disadvantages in a wider perspective.
Study Status:
Recruiting
Disease:
Amyotrophic Lateral Sclerosis , Motor Neuron Disease , Nervous System Diseases , Spinal Cord Diseases , Neurodegenerative Diseases , TDP-43 Proteinopathies
Study Type:
Interventional
Type of Intervention:
Device
Intervention Name:
Long term mechanical ventilation support, No long term mechanical ventilation support
Placebo:
Phase:
N/A
Study Chair(s)/Principal Investigator(s):
Ole-Bjørn Tysnes, Haukeland University Hospital
Clinicaltrials.gov ID:
Neals Affiliated?
No
Coordinating Center Contact Information
Ole-Bjørn Tysnes / email hidden; JavaScript is required / + 47 55975063
Study Sponsor:
Haukeland University Hospital
Estimated Enrollment:
200
Estimated Study Start Date:
04 / 12 / 2023
Estimated Study Completion Date:
08 / 21 / 2032
Posting Last Modified Date:
04 / 12 / 2023
Date Study Added to neals.org:
02 / 27 / 2023
Accepts healthy volunteers:
Yes
Minimum Age:
8 Years
Maximum Age:
N/A
Inclusion criteria for patients:1. A clinical diagnosis of probable ALS according to the revised El Escorial criteria
2. Progression of the illness leading the consulting physician to offer treatment with LTMV
3. Can communicate in Norwegian
Inclusion criteria for partners of ALS patients:
1. Partner of a patient with ALS with progression of the illness leading the consulting physician to offer treatment with LTMV
2. Can communicate in Norwegian
Inclusion criteria for children:
1. Children from 8 years and older having a parent who suffers from ALS with progression of the illness leading the consulting physician to offer treatment with LTMV
2. Can communicate in Norwegian
Exclusion criteria for patients, partners and children of ALS patients:
1. Potential participants with cognitive impairment or dementia.
Haukeland University Hospital | Recruiting
Ole-Bjørn Tysnes / +4755975063 / email hidden; JavaScript is required
Bergen
Norway
Akershus University Hospital | Not yet recruiting
Ola Nakken
Principal Investigator : Ola Nakken
Lørenskog
Norway
Oslo University Hospital | Not yet recruiting
Angelina Maniaol
Principal Investigator : Angelina Maniaol
Oslo
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Stavanger University Hospital | Not yet recruiting
Katrin Ruth Schlüter
Principal Investigator : Katrin Ruth Schlüter
Stavanger
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Universitetssykehuset Nord-Norge | Not yet recruiting
Margitta Kampmann
Principal Investigator : Margitta Kampmann
Tromsø
Norway
St. Olavs Hospital | Not yet recruiting
Helene Kvernmo
Principal Investigator : Helene Kvernmo
Trondheim
Norway