Factors Associated With Success of Non-invasive Positive Pressure Ventilation in Patients With Amyotrophic Lateral Sclerosis: A Retrospective Cohort Study

Study Purpose:

This is a retrospective cohort study to assess the factor associated with success of non-invasive positive ventilation in ALS patients.

Study Status:

Not recruiting



Study Type:


Type of Intervention:


Intervention Name:






Study Chair(s)/Principal Investigator(s):

Jaewon Beom, PhD, Department of Rehabilitation Medicine, Seoul National University Bundang Hospital

Clinicaltrials.gov ID:


Neals Affiliated?


Coordinating Center Contact Information

Full Study Summary:

Patients with ALS who were admitted to a tertiary hospital for initially applying non-invasive positive pressure ventilation (NIPPV). The objective of this study was to investigate factors associated with optimal NIPPV initiation and adherence, and to assess the long-term effects of NIPPV adherence in ALS patients.

Study Sponsor:

Seoul National University Bundang Hospital

Estimated Enrollment:


Estimated Study Start Date:

10 / 18 / 2022

Estimated Study Completion Date:

09 / 22 / 2023

Posting Last Modified Date:

11 / 01 / 2022

Date Study Added to neals.org:

10 / 17 / 2022

Minimum Age:

19 Years

Maximum Age:


Inclusion Criteria:

- Patients fulfilling the El Escorial World Federation criteria for probable, or definite ALS

- Aged ≥ 19 years

- Patients who performed blood gas analysis including venous blood gas and arterial blood gas before NIPPV application.

Exclusion Criteria:

- Patients who had experience in applying the NIPPV or currently using NIPPV

- Patients who applied in outpatient settings

- Patients who did not perform blood gas analysis before NIPPV application

- Patietns who had a history of asthma or COPD,

- Patients who didn't have any record of NIPPV application time

Seoul National University Bundang Hospital

Seongnam-si 13620
Korea, Republic of