Study of Structural and Functional Brain Connectivity Changes in ALS (CoALS-II)

Study Purpose:

This study will try to understand the difference in brain structure between ALS patients and healthy people of similar age. ALS is a condition affecting the nervous system with disruption of the brain networks. This study aims to understand these disruptions and determine their significance in ALS.

Study Status:



Amyotrophic Lateral Sclerosis

Study Type:


Type of Intervention:


Intervention Name:






Study Chair(s)/Principal Investigator(s):



Neals Affiliated?


Coordinating Center Contact Information

Full Study Summary:

Participants and healthy controls will be consented into the study. After consent, details including age, duration of disease, ALSFRS score, and grip strength will be collected. Participants will be trained to perform a grip and release task using a foam ball for 1 minute while inside an MRI scanner. Anatomical, functional and diffusion MRI sequences will be acquired during the scanning, and total scan time will be approximately 1 hour.

Study Sponsor:

Dartmouth-Hitchcock Medical Center

Estimated Enrollment:


Estimated Study Start Date:

06 / 08 / 2022

Estimated Study Completion Date:

12 / 01 / 2023

Posting Last Modified Date:

06 / 15 / 2022

Date Study Added to

06 / 03 / 2022

Minimum Age:

18 Years

Maximum Age:


Inclusion Criteria:

- Based on El Escorial Criteria we will select Probable or Definite ALS.

- Healthy controls age matched to ALS patients

- Subjects should be able to lie down in a scanner and undergo an hour-long MRI study

- Subjects should be able to understand instructions, provide consent and perform a hand task while inside the scanner

Exclusion Criteria:

- Unable to undergo MRI due to any reason

- Age <18

- ALS patients having high aspiration risk

- Patients having cognitive limitations which prevents them from understanding the study requirements, providing consent or perform tasks inside the scanner.

Dartmouth-Hitchcock Medical Center | Recruiting

Charlotte Jeffreys, MLS / 603-650-3834 / email hidden; JavaScript is required

Lebanon, New Hampshire 03756
United States