Investigation of the Use of 1 Minute Sit to Stand Test to Evaluate Physical Capacity and Effort-Related Desaturation in Individuals With Amyotrophic Lateral Sclerosis

Study Purpose:

The aim of this study is to investigate the usability of the 1 Minute Sit to Stand Test (1 MSTS) in evaluating physical capacity and effort-related desaturation in individuals with Amyotrophic Lateral Sclerosis (ALS). In this context, patients diagnosed with ALS who meet the inclusion criteria will be included in the study. For the physical capacity assessment of patients with ALS at different ambulatory levels included in this study, a 6 minutes walking test (6 MWT) and a 1 MSTS will be applied. Before and at the end of the test, the severity of dyspnea and leg fatigue of the patients will be determined by the Modified Borg Scale; effort-induced desaturation and heart rate by fingertip pulse oximetry; peripheral muscle strength (for the quadriceps femoris muscle) will be evaluated with a hand held dynamometer. When the studies are examined, it has been determined that the 6 MWT is relatively difficult to tolerate in individuals with ALS, it may be difficult to provide the necessary space and equipment for the test, and a shorter, easy-to-apply, and practical evaluation method that can be used instead of this test in the clinic is needed. As a result of this study, the usability of the 1 MSTS in individuals with ambulatory ALS in evaluating physical capacity and desaturation due to effort will be revealed.

Study Status:

Not yet recruiting


Amyotrophic Lateral Sclerosis

Study Type:


Type of Intervention:


Intervention Name:






Study Chair(s)/Principal Investigator(s):

Gökşen KURAN ASLAN, Asst. Prof., Istanbul University - Cerrahpasa (IUC), İrem Kurt, Pt., MSc., Istanbul University - Cerrahpasa (IUC), Tuğba Akgüller, Pt., MSc., Istanbul University - Cerrahpasa (IUC), Feray Güngör, Pt., MSc., Istanbul University - Cerrahpasa (IUC), Nazlı Güngör, Pt., MSc., Istanbul University - Cerrahpasa (IUC) ID:


Neals Affiliated?


Coordinating Center Contact Information

Asena A. Gülnergiz, Pt., MSc. / email hidden; JavaScript is required / 000000000000

Study Sponsor:

Istanbul University - Cerrahpasa (IUC)

Estimated Enrollment:


Estimated Study Start Date:

05 / 30 / 2022

Estimated Study Completion Date:

03 / 01 / 2023

Posting Last Modified Date:

03 / 29 / 2022

Date Study Added to

12 / 09 / 2021

Minimum Age:

18 Years

Maximum Age:


Inclusion Criteria:

- Diagnosed with ALS

- 18 years and over

- Ambulatory

- Volunteer to participate in the study

Exclusion Criteria:

- Having a comorbidity that may affect the results of the study (orthopedic, cardiopulmonary, orthopedic, psychiatric, etc.)

- Not willing to participate in the study

Istanbul University-Cerrahpasa

Gökşen Kuran Aslan, Asst. Prof.