Effectiveness of Expiratory Muscle Strength Training for Improving Communication in ALS

Study Purpose:

A tele-health treatment study for individuals with early stage ALS with the aim to improve communication, cough response, and respiratory strength. All participants complete a respiratory strength training program using an Expiratory Muscle Strength Training (EMST 150) device from the comfort of their homes for 6 weeks.

Study Status:

Not recruiting


Amyotrophic Lateral Sclerosis

Study Type:


Type of Intervention:


Intervention Name:

Expiratory Muscle Strength Training (EMST-150)




Study Chair(s)/Principal Investigator(s):

Jessica E Huber, Ph.D., Purdue University

Clinicaltrials.gov ID:


Neals Affiliated?


Coordinating Center Contact Information

Purdue University

West Lafayette, Indiana, 47906 United States

Full Study Summary:

The investigators are looking for people with early stage ALS to participate in a completely tele-health (no in-person visits required) treatment study examining the effects of an Expiratory Muscle Strength Training device (EMST-150) on communication, cough, and respiratory strength. Participants will be required to attend 2 virtual baseline assessment sessions followed by 12 additional virtual training sessions (2 per week for 6 weeks). Participants should plan to be actively enrolled in the study for ~10 weeks (3 weeks of baseline monitoring followed by 6 weeks of training). Participants will also be required to fill out a series of questionnaires assessing the EMST's effectiveness via tele-health.

Study Sponsor:

Purdue University

Participant Duration:

~10 weeks (3 weeks of baseline monitoring followed by 6 weeks of training)

Estimated Enrollment:


Estimated Study Start Date:

01 / 01 / 2021

Estimated Study Completion Date:

08 / 01 / 2022

Posting Last Modified Date:

06 / 03 / 2022

Date Study Added to neals.org:

08 / 12 / 2021

Minimum Age:

40 Years

Maximum Age:

70 Years

Can participants use Riluzole?


Inclusion Criteria:

- Diagnosis of ALS

- Within the early stages of disease progression (i.e., able to talk, breathe, and eat independently)

- Speaker of English

- Have a family member/caregiver willing to assist as needed

- Have access to an electronic device and internet for tele-health

Exclusion Criteria:

- A history of neurological disease (besides ALS)

- A history of asthma or respiratory problems (e.g., COPD, emphysema)

- A history of head, neck, or chest surgery (except mastectomy)

- A history of smoking within the last 5 years

- Reliance on mechanical ventilation (including CPAP)

Purdue University

West Lafayette, Indiana 47906
United States