Staging System in Amyotrophic Lateral Sclerosis

Study Purpose:

Recently two staging systems have been proposed for amyotrophic lateral sclerosis (ALS), based on clinical milestones The King's college clinical staging system (1) and ALS Milano-Torino Staging (ALS-MITOS) (2). Further research to validate and develop an accurate staging system in different populations will improve our understanding of its pathogenesis, disease activity and progression.

General objective : To validate the two previously proposed staging system and to test the interest of considering Neurofilament biomarkers in these systems.

Specific objectives: 1) To validate the two classification systems in an independent cohort of patients with ALS followed-up in the ALS expert center of Limoges (France) 2) To assess the interest of Nf biomarkers to predict neurological decline

Study Status:

Recruiting

Disease:

Amyotrophic Lateral Sclerosis

Study Type:

Observational

Type of Intervention:

N/A

Intervention Name:

N/A

Placebo:

N/A

Phase:

N/A

Study Chair(s)/Principal Investigator(s):

N/A

Clinicaltrials.gov ID:

NCT04858555

Neals Affiliated?

No

Coordinating Center Contact Information

Study Sponsor:

University Hospital, Limoges

Estimated Enrollment:

50

Estimated Study Start Date:

12 / 02 / 2022

Estimated Study Completion Date:

12 / 02 / 2024

Posting Last Modified Date:

03 / 21 / 2023

Date Study Added to neals.org:

04 / 26 / 2021