Staging System in Amyotrophic Lateral Sclerosis

Study Purpose:

Recently two staging systems have been proposed for amyotrophic lateral sclerosis (ALS), based on clinical milestones The King's college clinical staging system (1) and ALS Milano-Torino Staging (ALS-MITOS) (2). Further research to validate and develop an accurate staging system in different populations will improve our understanding of its pathogenesis, disease activity and progression.

General objective : To validate the two previously proposed staging system and to test the interest of considering Neurofilament biomarkers in these systems.

Specific objectives: 1) To validate the two classification systems in an independent cohort of patients with ALS followed-up in the ALS expert center of Limoges (France) 2) To assess the interest of Nf biomarkers to predict neurological decline

Study Status:



Amyotrophic Lateral Sclerosis

Study Type:


Type of Intervention:


Intervention Name:






Study Chair(s)/Principal Investigator(s):



Neals Affiliated?


Coordinating Center Contact Information

Philippe Couratier, Pr / email hidden; JavaScript is required / 00335 55 05 65 61

Full Study Summary:

Amyotrophic lateral sclerosis (ALS) is a rare, fatal neurodegenerative disease of the human motor system. Recently two new staging systems have been proposed for ALS, based on clinical milestones related also to the spreading pattern of the disease (1,2). Furthermore, biomarker development is still an essential component of future therapeutic development in ALS. Thus, it is also important to acknowledge the value of biomarker research in supporting or revealing fundamental pathophysiological mechanisms in ALS.

The proposed staging systems: have been recently tested in two independent cohorts (3,4) with results that were not fully consistent (ii) did not considered the potential value of biomarkers.

Study Sponsor:

University Hospital, Limoges

Estimated Enrollment:


Estimated Study Start Date:

12 / 02 / 2022

Estimated Study Completion Date:

12 / 02 / 2024

Posting Last Modified Date:

03 / 21 / 2023

Date Study Added to

04 / 26 / 2021

Minimum Age:


Maximum Age:


Inclusion Criteria:

- ALS cases recruited for retrospectively (between) 2007 to 2016 for the retrospective cohort

- ALS cases recruited for prospectively by the ALS expert center of Limoges for one year.

Exclusion Criteria:

- Previous neurosurgical operations

- A recent history of neurotrauma

- Peripheral neuropathies

- ALS/frontotemporal dementia (ALS/FTD)

Limoges University Hospital | Recruiting

Philippe COURATIER, Pr

Limoges 87042

Tours University Hospital | Recruiting

Philippe CORCIA, Pr / 0033247473724 / email hidden; JavaScript is required

Tours 37044