Study Purpose:Amyotrophic lateral sclerosis (ALS) is a disabling and rapidly progressive neurodegenerative disorder. There is no treatment that significantly slows progression. Our project aims to find new biomarkers in MRI at three levels: cerebral, medullary and muscular. These markers could allow an earlier diagnosis of the disease by showing more specific lesions of ALS and to quantify these lesions to measure the progression of the disease. This study will use advanced Magnetic Resonance Imaging (MRI) techniques High field (3T) and very high field (7T) MRI. Results from neurological and electrophysiological tests will be compared to the MRI. Subjects will be recruited from ALS center of Marseille, France. MRI will be done on ALS patients at baseline, at 3 month and at 6 month intervals.
Amyotrophic Lateral Sclerosis
Type of Intervention:
Muscular MRI, Electrophysiological exam, Brain MRI, Spinal cord MRI
Study Chair(s)/Principal Investigator(s):
Emilie Garrido Pradalié, Direction Recherche Santé APHM
Coordinating Center Contact Information
Assistance Publique Hopitaux De Marseille
Estimated Study Start Date:
06 / 16 / 2021
Estimated Study Completion Date:
12 / 31 / 2026
Posting Last Modified Date:
08 / 02 / 2022
Date Study Added to neals.org:
12 / 31 / 2020
- Patients will be adults with a diagnosis of ALS.
- Healthy controls will also be recruited and will be age- and gender-matched to patients.
- Patients able to undergo a brain MRI for approximately an hour.
- Subjects with other psychiatric or CNS or PNS diseases.
- Subjects ineligible for MRI investigation due to a pacemaker or other metallic foreign body, or significant claustrophobia that could affect the ability to have an MRI scan.
Shahram Attarian | Recruiting