A Study on the Natural History and Clinical Features of Amyotrophic Lateral Sclerosis (ALS) in Mainland China

Study Purpose:

1. Describe the distribution of ALS in mainland China, to explore the differences in the number of ALS in different times, regions and populations in order to further explore the causes affecting the distribution of ALS;

2. To investigate the cause of ALS in mainland China in the crowd disease development process and the corresponding characteristics change ;

3. To explore the effect of prognosis of ALS;

Study Status:

Recruiting

Disease:

Amyotrophic Lateral Sclerosis

Study Type:

Observational

Type of Intervention:

N/A

Intervention Name:

N/A

Placebo:

N/A

Phase:

N/A

Study Chair(s)/Principal Investigator(s):

Dongsheng Fan, MD.PHD, Peking University Third Hospital

Clinicaltrials.gov ID:

NCT04454892

Neals Affiliated?

Coordinating Center Contact Information

Lu Tang, Msc / email hidden; JavaScript is required / 13811854649

Full Study Summary:

With the development of supportive measures, the natural history of ALS has changed. Researchers compared the natural history of ALS patients from 1999-2004 and 1984-1998 and found that the median survival time was significantly longer in the former than in the latter (4.32 years vs. 3.22 years) and that the disease progression was slower in the former, even after adjusting for other confounding factors. Although previous studies have provided reference for the diagnosis and treatment of ALS, the etiology of ALS is still unknown, and the relevant clinical features and natural history of ALS still lack the verification of large samples. Therefore, the research on the natural history of ALS is of great significance to further increase the understanding of ALS and provide new evidence for the diagnosis and treatment of ALS.

Study Sponsor:

Peking University Third Hospital

Estimated Enrollment:

3000

Estimated Study Start Date:

11 / 01 / 2019

Estimated Study Completion Date:

12 / 01 / 2030

Posting Last Modified Date:

07 / 02 / 2020

Date Study Added to neals.org:

07 / 02 / 2020

Minimum Age:

N/A

Maximum Age:

N/A

Inclusion Criteria:

- Patients were diagnosed with ALS recruited from all participant clinical centers.The diagnosis of ALS was made using the revised El Escorial criteria for definite, probable, lab-supported, and possible.

Exclusion Criteria:

- Decline to follow-up.

Peking University Third Hospital | Recruiting

Dongsheng Fan, PHD. MD

Beijing
China