A Registered Cohort Study on Amyotrophic Lateral Sclerosis

Study Purpose:

Amyotrophic lateral sclerosis (ALS) is a kind of motor neuron degeneration disorder without effective therapy. This registered cohort study will provide further insights into the clinical course of ALS, and investigate disease-relative risk factors and the genetic background of Chinese ALS patients.

Study Status:

Recruiting

Disease:

Amyotrophic Lateral Sclerosis

Study Type:

Observational

Type of Intervention:

N/A

Intervention Name:

N/A

Placebo:

N/A

Phase:

N/A

Study Chair(s)/Principal Investigator(s):

Ning Wang, MD,PhD, First Affiliated Hospital of Fujian Medical University

Clinicaltrials.gov ID:

NCT04008329

Neals Affiliated?

No

Coordinating Center Contact Information

Qi-Jie Zhang, PhD / email hidden; JavaScript is required / 086-591-87982772

Full Study Summary:

Amyotrophic lateral sclerosis (ALS) is the most common form of motor neuron disease (MND), which is characterized with highly clinical heterogeneity and no effective treatment is available now. The purpose of this registered cohort is to observe the natural history of ALS patients in China, and then identify some factors correlated with disease progression. Besides, ALS-related gene mutations will be screened and explore novel disease causing gene as well.

Study Sponsor:

First Affiliated Hospital of Fujian Medical University

Estimated Enrollment:

2000

Estimated Study Start Date:

07 / 05 / 2019

Estimated Study Completion Date:

07 / 01 / 2059

Posting Last Modified Date:

03 / 22 / 2021

Date Study Added to neals.org:

07 / 05 / 2019

Minimum Age:

N/A

Maximum Age:

N/A

Inclusion Criteria:

- Amyotrophic Lateral Sclerosis patients fulfilling the El Escorial criteria (including definite, probable and possible)

- Progressive muscular atrophy

- Primary lateral sclerosis

- Progressive bulbar palsy

Exclusion Criteria:

- History of serious head trauma or neuropsychiatric disease

- Decline to participate

Sub-Investigator : Wan-Jian Chen

Department of Neurology, First Affiliated Hospital of Fujian Medical University | Recruiting

Qi-Jie Zhang, PhD / 086-591-87982772 / email hidden; JavaScript is required

Ning Wang, PhD / 086-591-87982772 / email hidden; JavaScript is required

Principal Investigator : Ning Wang, MD,PhD

Fuzhou, Fujian 350005
China