Study Purpose:The main objective is to determine the origin of somatosensory alteration in patients with ALS and to evaluate its impact on brain activity by coupling different imaging modalities and indirect electrophysiology.
The secondary objective is to evaluate whether the observed functional changes in MEG / EEG and functional MRI correlate with structural lesions revealed with diffusion MRI (anatomo-functional connectivity of the brain).
Amyotrophic Lateral Sclerosis
Type of Intervention:
functional MRI, structural MRI, EEG/MEG
Study Chair(s)/Principal Investigator(s):
Pierre-Francois Pradat, MD, PhD, Assistance Publique - Hôpitaux de Paris, Veronique Marchand-Pauvert, PhD, Institut National de la Santé Et de la Recherche Médicale, France
Coordinating Center Contact Information
Full Study Summary:
Functional MRI will be performed during electrical stimulation of ulnar nerve and during mechanical vibration of ADM tendon.
Brain diffusion MRI will be performed. Anatomical MRI will be done for source location. Brain resting state activity will be recorded with MEG/EEG and fMRI.
Institut National de la Santé Et de la Recherche Médicale, France
Estimated Study Start Date:
11 / 26 / 2018
Estimated Study Completion Date:
04 / 06 / 2022
Posting Last Modified Date:
12 / 21 / 2018
Date Study Added to neals.org:
10 / 03 / 2018
80 YearsInclusion Criteria:
- ALS, MRC score ≥ 4 at least in one hand
- Controls: no history of neurological disorders, right-handed
- contraindication to MRI
Hopital Pitie-Salpetriere | Recruiting