Study Purpose:
The main objective is to determine the origin of somatosensory alteration in patients with ALS and to evaluate its impact on brain activity by coupling different imaging modalities and indirect electrophysiology.The secondary objective is to evaluate whether the observed functional changes in MEG / EEG and functional MRI correlate with structural lesions revealed with diffusion MRI (anatomo-functional connectivity of the brain).
Study Status:
Not recruiting
Disease:
Amyotrophic Lateral Sclerosis
Study Type:
Interventional
Type of Intervention:
Device
Intervention Name:
functional MRI, structural MRI, EEG/MEG
Placebo:
No
Phase:
N/A
Study Chair(s)/Principal Investigator(s):
Pierre-Francois Pradat, MD, PhD, Assistance Publique - Hôpitaux de Paris, Veronique Marchand-Pauvert, PhD, Institut National de la Santé Et de la Recherche Médicale, France
Clinicaltrials.gov ID:
Neals Affiliated?
No
Coordinating Center Contact Information
Veronique Marchand-Pauvert, PhD / email hidden; JavaScript is required / 142161120
Full Study Summary:
Functional MRI will be performed during electrical stimulation of ulnar nerve and during mechanical vibration of ADM tendon.
Brain diffusion MRI will be performed. Anatomical MRI will be done for source location. Brain resting state activity will be recorded with MEG/EEG and fMRI.
Study Sponsor:
Institut National de la Santé Et de la Recherche Médicale, France
Estimated Enrollment:
52
Estimated Study Start Date:
11 / 26 / 2018
Estimated Study Completion Date:
04 / 06 / 2022
Posting Last Modified Date:
12 / 21 / 2018
Date Study Added to neals.org:
10 / 03 / 2018
Minimum Age:
30 Years
Maximum Age:
80 Years
Inclusion Criteria:- ALS, MRC score ≥ 4 at least in one hand
- Controls: no history of neurological disorders, right-handed
Exclusion Criteria:
- contraindication to MRI
Hopital Pitie-Salpetriere | Recruiting
Veronique Marchand-Pauvert, PhD / 142161120 Ext. 33 / email hidden; JavaScript is required
Paris 75013
France