Cognitive Impairment in ALS: Screening Tools, Experiences and Prognosis

Study Purpose:

This study evaluate use of a translated Norwegian version of the Edinburgh cognitive and behavioral amyotrophic lateral sclerosis screen (ECAS-N) as an early predictor in car-driving, working and use of advanced life-prolonging therapy.

Study Status:

Recruiting

Disease:

Amyotrophic Lateral Sclerosis , Cognitive Impairment

Study Type:

Observational

Type of Intervention:

N/A

Intervention Name:

N/A

Placebo:

N/A

Phase:

N/A

Study Chair(s)/Principal Investigator(s):

Tina Taule, PhD, Haukeland University Hospital

Clinicaltrials.gov ID:

NCT03578796

Neals Affiliated?

No

Coordinating Center Contact Information

Tina Taule, PhD / email hidden; JavaScript is required / +47 41694143

Full Study Summary:

Cognitive impairment is present in about 30-50% of the patients with amyotrophic lateral sclerosis (ALS). Screening of cognitive and behavioral impairment is a distinct recommendation in ALS-specific health care. However, knowledge in how cognitive impairment shall influence health-care professionals' information given to patients and in decision making is lacking.

One of the major challenges in ALS management is the decision-making on advanced therapy. There is a lack of knowledge in how cognitive impairment in ALS shall be interfere on complex medical treatment that will affect quality of life or life itself. This means significant implications not only to the ALS patient and the community, but also the family and especially the spouse. Thus, further investigation of the ECAS-N and its potential in clinical use is needed. The scale may contribute a more proactive treatment better tailored to individual needs. The objective is to evaluate if the ECAS-N can be applied as an early predictor in car-driving, working and use of advanced life-prolonging therapy

Study Sponsor:

Haukeland University Hospital

Estimated Enrollment:

50

Estimated Study Start Date:

05 / 01 / 2017

Estimated Study Completion Date:

12 / 31 / 2022

Posting Last Modified Date:

08 / 09 / 2022

Date Study Added to neals.org:

07 / 06 / 2018

Minimum Age:

N/A

Maximum Age:

N/A

Inclusion Criteria:

- Voluntary informed consent

- Native Norwegian speaker

Exclusion Criteria:

- Great difficulties in writing or reading

- Comorbid medical history

- Neurological disorders others than ALS

- Psychiatric history of importance to cognitive function

Haukeland University Hospital | Recruiting

Tina Taule, PhD / +47 41694143 / email hidden; JavaScript is required

Ole-Bjørn Tysnes, Professor / email hidden; JavaScript is required

Bergen 5021
Norway