Predictive Factors for the Diagnosis of Early Noninvasive Ventilation Equipment in Patients With Amyotrophic Lateral Sclerosis

Study Purpose:

To compensate for insufficiency of diagnostic tools, the present study propose to look for the predictive factors of an early fitting by noninvasive ventilation.

Study Status:



Amyotrophic Lateral Sclerosis

Study Type:


Type of Intervention:

Diagnostic Test

Intervention Name:

diagnosis variables




Study Chair(s)/Principal Investigator(s):

Marion Dupuis, MD, University Hospital, Toulouse ID:


Neals Affiliated?


Coordinating Center Contact Information

Marion Dupuis, MD / email hidden; JavaScript is required / 5 67 77 16 91

Full Study Summary:

Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease. The diagnosis of this diaphragmatic dysfunction in the ALS subject is done all too often on the occasion of a hospitalization for acute respiratory insufficiency, which aggravates then the prognosis of the patients.

The presence of these factors at diagnosis will allow more surveillance to detect early diaphragmatic insufficiency and establish a NIV (Non Invasive Ventilation), the only therapeutic measure definitely improving the quality of life and survival of patients. A clinical score will be established to determine the risk of early Non Invasive Ventilation (NIV) equipment.

Study Sponsor:

University Hospital, Toulouse

Estimated Enrollment:


Estimated Study Start Date:

12 / 14 / 2017

Estimated Study Completion Date:

12 / 14 / 2022

Posting Last Modified Date:

09 / 01 / 2021

Date Study Added to

03 / 02 / 2018

Minimum Age:

18 Years

Maximum Age:


Inclusion Criteria:

- diagnosis of amyotrophic lateral sclerosis just performed,

- Patient who do not have the criteria for fitting by NIV and who have a Vital capacity ≥ 70% of theoretical values

Exclusion Criteria:

- Patient under court bail/ guardianship

- Lack of consent for participation in the study

- Presence of criteria for setting up the NIV for diagnosis according to the HAS (HealthCare Analytics Summit) 2006 recommendations

- Vital capacity <70% of the theoretical values

- Patient under Continuous Positive Pressure (CPP) or NIV for a respiratory pathology other

University Hospital Toulouse | Recruiting

Marion Dupuis, MD / 5 67 77 16 91 Ext. 33 / email hidden; JavaScript is required

Toulouse 31052