Study Purpose:Introduction: About 50-60% of Amyotrophic Lateral Sclerosis (ALS) is characterized by hypermetabolism, defined as 10% or more excess resting energy expenditure (REE) compared to theoretical values. Harris and Benedict's (HB) formula is the equation mainly used to predict REE, but others are also applied in current practice. The present study aimed to assess REE in ALS patients compared to control populations and to compare six formulas commonly used to predict REE.
Nutritional assessments were performed in ALS patients and in two control populations without hypermetabolism: healthy elderly people (control 1) and patients with non-restrictive-eating disorders (control 2). Weight, height and body composition (by bioimpedance analysis) were assessed.
EE was measured (mREE) by indirect calorimetry and calculated (cREE) using HB 1919 and 1984, World Schofield, De Lorenzo, Johnstone and Mifflin formulas. Mann-Whitney and Chi2 tests were used to compare the equations.
Amyotrophic Lateral Sclerosis
Type of Intervention:
Study Chair(s)/Principal Investigator(s):
Coordinating Center Contact Information
University Hospital, Limoges
Estimated Study Start Date:
11 / 01 / 1996
Estimated Study Completion Date:
11 / 01 / 2014
Posting Last Modified Date:
12 / 22 / 2017
Date Study Added to neals.org:
12 / 22 / 2017
- ALS patients
- 18 years old or more
- IC and nutritional assessment within 1.5 months
- delay between diagnosis and IC < 12 months
Limoges 87 042