Case-control and Population Questionnaire Studying Environmental Risk Factors and Neurological Diseases

Study Purpose:

The proposed research is particularly relevant to the National ALS Registry and public environmental health issues because it addresses the potential environmental causes of sporadic ALS. The research will develop an ALS surveillance program in Ohio that can be compared with the national and State-Metro Surveillance Programs of the National ALS Registry, and novel methodologies to determine the role of the cyanobacterial toxin, BMAA (beta-methylamino-L-alanine), and other environmental toxins/toxicants as risk factors for ALS. This work will advance the mission of the Centers for Disease Control Agency for Toxic Substances and Disease Registry (CDC ATSDR) National ALS Registry by offering data on ALS cases in Ohio that address public health concerns over the effects of chronic exposure to cyanobacterial blooms in Lake Erie.

Study Status:

Not recruiting

Disease:

Amyotrophic Lateral Sclerosis

Study Type:

Observational

Type of Intervention:

N/A

Intervention Name:

N/A

Placebo:

N/A

Phase:

N/A

Study Chair(s)/Principal Investigator(s):

N/A

Clinicaltrials.gov ID:

NCT02916966

Neals Affiliated?

No

Coordinating Center Contact Information

Cleveland Clinic Foundation

Cleveland, Ohio, 44195 United States

Study Sponsor:

Dartmouth-Hitchcock Medical Center

Estimated Enrollment:

2000

Estimated Study Start Date:

10 / 01 / 2016

Estimated Study Completion Date:

12 / 01 / 2025

Posting Last Modified Date:

09 / 06 / 2022

Date Study Added to neals.org:

09 / 28 / 2016

Minimum Age:

18 Years

Maximum Age:

80 Years

Can participants use Riluzole?

Yes

Inclusion Criteria:

- ALS

- Non-neurodegenerative controls

- Can willingly give consent

- Over 18 years of age

Exclusion Criteria:

- Cannot give consent

- Under 18 years of age

Cleveland Clinic Foundation

Cleveland, Ohio 44195
United States