Innovative Ultrasound Technology in Neuromuscular Disease (AQUIRe)

Study Purpose:

This study is utilizing ultrasound measurement to measure neuromuscular disease status in adult patients. The hypothesis is the by quantifying ultrasound data, it is possible that ultrasound can be utilized as a tool to determine if a disease is responding to therapy or progressing.

Study Status:

Not recruiting


Amyotrophic Lateral Sclerosis , Muscular Dystrophy , Radiculopathy , Myopathy , Polyneuropathy and Mononeuropathies , Trauma Injury , Orthopedic Disorder

Study Type:


Type of Intervention:


Intervention Name:






Study Chair(s)/Principal Investigator(s):



Neals Affiliated?


Coordinating Center Contact Information

Beth Israel Deaconess Medical Center

Boston, Massachusetts, 02215 United States

Full Study Summary:

Primary Outcome Measures:
-Quantitative ultrasound data, including quantified grayscale data and backscattered acoustic data [ Time Frame: 1 year ] [ Designated as safety issue: No ]
-Ultrasound data will be collected on multiple muscles in each person. The images will then be quantified using either 1. A grayscale technique in which the images themselves are analyzed via standard image software (e.g., Adobe Photoshop) as to level of echo intensity in a pre-specific region of interest or 2. the raw quantified backscatter data is captured by the transducer, expressed as a unit of power, in the same pre-specified area of interest

Study Sponsor:

Beth Israel Deaconess Medical Center

Estimated Enrollment:


Estimated Study Start Date:

12 / 01 / 2013

Estimated Study Completion Date:

03 / 01 / 2020

Posting Last Modified Date:

03 / 11 / 2022

Date Study Added to

04 / 07 / 2014

Minimum Age:

18 Years

Maximum Age:

90 Years

Inclusion Criteria:

- History of a well-defined, localized or generalized neuromuscular condition producing weakness or muscle atrophy, including disuse atrophy.

Exclusion Criteria:

- Multiple generalized neuromuscular conditions.

Beth Israel Deaconess Medical Center

Boston, Massachusetts 02215
United States