Cervical Spinal Cord Metabolism and Microstructure in Amyotrophic Lateral Sclerosis(ALS)

Study Purpose:

The investigators want to know if magnetic resonance imaging can accurately provide an early diagnosis of amyotrophic lateral sclerosis (ALS).

Study Status:

Not recruiting


Amyotrophic Lateral Sclerosis

Study Type:


Type of Intervention:


Intervention Name:

MRI, Clinical Exam




Study Chair(s)/Principal Investigator(s):

Bradley Foerster, M.D., University of Michigan Hospital

Clinicaltrials.gov ID:


Neals Affiliated?


Coordinating Center Contact Information

University of Michigan

Ann Arbor, Michigan, 48109 United States

Full Study Summary:

Currently there is no definitive diagnostic test for amyotrophic lateral sclerosis (ALS). The investigators' goal is to determine if magnetic resonance imaging can provide an accurate diagnosis of ALS by looking at chemical concentrations in the spinal cord at the neck level which show up in MRI imaging and compare these chemical concentrations to corresponding measures in healthy control subjects.

Study Sponsor:

University of Michigan

Estimated Enrollment:


Estimated Study Start Date:

10 / 01 / 2013

Estimated Study Completion Date:

08 / 01 / 2015

Posting Last Modified Date:

06 / 04 / 2018

Date Study Added to neals.org:

12 / 04 / 2013

Minimum Age:

18 Years

Maximum Age:

80 Years

Inclusion Criteria:

1. Adults age 18 to 80 years of age.

Exclusion Criteria:

1. Do not have active substance abuse

2. Do not have co-morbid psychiatric disease

3. Do not have opportunistic central nervous system infection

4. Do not have cerebrovascular disease

5. Do not have a contraindication for magnetic resonance imaging(MRI)(e.g. cardiac pacemaker, ferromagnetic or metallic implants).

6. Are not pregnant

7. Have not had cervical spinal surgery(neck) -

University of Michigan Hospital

Ann Arbor, Michigan 48109
United States