Study Purpose:
To combine several brain imaging techniques to develop a new diagnostic test to help with earlier diagnosis of amyotrophic lateral sclerosis.Study Status:
Not recruiting
Disease:
Amyotrophic Lateral Sclerosis
Study Type:
Interventional
Type of Intervention:
Diagnostic Test
Intervention Name:
MRI(magnetic resonance imaging)
Placebo:
Phase:
N/A
Study Chair(s)/Principal Investigator(s):
Bradley Foerster, M.D., University of Michigan Hospital
Clinicaltrials.gov ID:
Neals Affiliated?
No
Coordinating Center Contact Information
University of Michigan Hospital
Ann Arbor, Michigan, 48109 United States
Full Study Summary:
Early diagnosis and lack of understanding of the pathophysiology of ALS remain a significant obstacle to making a timely intervention to help patients suffering from this fatal disease. We envision a future in which neuroimaging techniques will be a critical tool in the diagnostic work-up of ALS. Advanced neuroimaging techniques offer great potential in identifying central nervous system metabolite and cellular alterations in ALS. We propose an innovative approach to combine complementary advanced MRI techniques to interrogate brain chemistry (MRS), brain microstructure (DTI) and brain function (fcMRI) and develop a clinically relevant discriminatory disease model.
Study Sponsor:
University of Michigan
Estimated Enrollment:
50
Estimated Study Start Date:
04 / 01 / 2012
Estimated Study Completion Date:
10 / 01 / 2015
Posting Last Modified Date:
06 / 04 / 2018
Date Study Added to neals.org:
11 / 27 / 2013
Minimum Age:
18 Years
Maximum Age:
80 Years
Inclusion Criteria:1. 18 years of age or older
2. subjects with ALS (amyotrophic lateral sclerosis)
3. healthy subjects -
Exclusion Criteria:
1. Active substance abuse
2. Has co-morbid psychiatric disease
3. Has opportunistic CNS (central nervous system) infection
4. Has a history of head injury
5. Has a contraindication for MRI (e.g. cardiac pacemaker, ferromagnetic or metallic implants)
6. Pregnant
University of Michigan Hospital
Ann Arbor, Michigan
48109
United States