Study Purpose:
The purpose of this study is to collect biofluid samples for the banking and usage in ALS research. Through comparison of these samples, the researchers hope to learn more about the underlying cause of ALS, as well as find unique biological markers, which could be used to develop new therapies.Study Status:
Not recruiting
Disease:
Amyotrophic Lateral Sclerosis , Nervous System Diseases , Sclerosis , Motor Neuron Disease , Spinal Cord Diseases , Central Nervous System Diseases , Neurodegenerative Diseases , Neuromuscular Diseases , ALS
Study Type:
Observational
Type of Intervention:
N/A
Intervention Name:
N/A
Placebo:
N/A
Phase:
N/A
Study Chair(s)/Principal Investigator(s):
James D. Berry, MD, MPH, Massachusetts General Hospital
Clinicaltrials.gov ID:
Neals Affiliated?
Yes
Coordinating Center Contact Information
Mass General Hospital
Neurological Clinical Research Institute (NCRI)
Boston, Massachusetts, 02114 United States
Full Study Summary:
Study Sponsor:
Massachusetts General Hospital
Participant Duration:
up to 36 months
Estimated Enrollment:
139
Estimated Study Start Date:
07 / 31 / 2011
Estimated Study Completion Date:
12 / 31 / 2016
Posting Last Modified Date:
05 / 30 / 2017
Date Study Added to neals.org:
12 / 20 / 2011
Minimum Age:
18 Years
Maximum Age:
N/A
Can participants use Riluzole?
Yes
Inclusion Criteria:- Age 18 or older
- Diagnosis of suspected, possible, probable or definite ALS according to El Escorial Criteria
- Vital capacity (VC) at least 50 percent predicted
- Able to undergo multiple lumbar punctures
Exclusion Criteria:
- Abnormal CSF pressure or intracranial/intraspinal tumors
- Use of anticoagulant medication that cannot be safely withheld
- Bleeding disorders
- This is a partial listing.
Barrow Neurological Institute
Phoenix, Arizona
85013
United States
Mayo Clinic Jacksonville
Jacksonville, Florida
32224
United States
Emory University
Atlanta, Georgia
30322
United States
Massachusetts General Hospital
Boston, Massachusetts
02114
United States
University of Massachusetts Medical Center
Worcester, Massachusetts
01655
United States
University of Pittsburgh
Pittsburgh, Pennsylvania
15213
United States