Study Purpose:We are collecting blood samples, clinical and family information from ALS (amyotrophic lateral sclerosis) patients and their families to identify causes of ALS and ALS/dementia.
Amyotrophic Lateral Sclerosis (ALS) , Familial Amyotrophic Lateral Sclerosis , Amyotrophic Lateral Sclerosis With Frontotemporal Dementia , Lou Gehrig's Disease , Motor Neuron Disease , Primary Lateral Sclerosis
Type of Intervention:
Study Chair(s)/Principal Investigator(s):
Teepu Siddique, MD, Northwestern University Feinberg School of Medicine
Coordinating Center Contact Information
Northwestern University Feinberg School of Medicine
Chicago, Illinois, 60611 United States
Full Study Summary:
The investigators are collecting blood samples, family and medical histories of patients with all types of ALS, (familial and sporadic, with and without frontotemporal dementia, and primary lateral sclerosis and particular family members. Samples are coded to maintain confidentiality. Travel is not necessary.
As well as seeking to identify new genes implicated in ALS, the investigators continue our study of families with known genetic mutations to more fully characterize that disease mechanism.
Linkage analysis and affected relative pair analysis will be used to identify causative FALS genes and disequilibrium analysis and association studies are being done for sporadic ALS.
Results from these studies will provide insight into the underlying disease mechanisms of ALS and provide targets for therapeutic interventions.
Estimated Study Start Date:
01 / 01 / 1991
Estimated Study Completion Date:
12 / 01 / 2025
Posting Last Modified Date:
09 / 18 / 2020
Date Study Added to neals.org:
01 / 13 / 2009
Can participants use Riluzole?
- Patients with Amyotrophic Lateral Sclerosis or ALS and frontotemporal dementia
- Selected family members, generally brothers and sisters of an ALS patient, the patient's parents
- Under 18 years old
Northwestern University Feinberg School of Medicine | Recruiting
Principal Investigator : Teepu Siddique