The Pre-symptomatic Familial Amyotrophic Lateral Sclerosis (Pre-fALS) Study

Study Purpose:

Pre-fALS is a prospective natural history and biomarker study of people not yet affected with ALS, but who are at genetic risk for developing ALS. The investigators aim to recruit unaffected (healthy) people from familial ALS (fALS) pedigrees in which a known genetic mutation associated with ALS has been identified; for this study, a fALS pedigree is one with two biologically related individuals who have or have had ALS and/or FTD. Individuals who may be at genetic risk for ALS and who belong to families with at least one affected family member who has tested positive for a known ALS genetic mutation may also be eligible to participate. Our goal is to study the pre-symptomatic phase, onset and progression of ALS and to learn more about genetic and environmental factors that put people at risk for developing ALS.

Study Status:

Recruiting

Disease:

Amyotrophic Lateral Sclerosis

Study Type:

Observational

Type of Intervention:

N/A

Intervention Name:

N/A

Placebo:

N/A

Phase:

N/A

Study Chair(s)/Principal Investigator(s):

Michael G Benatar, MD, PhD., University of Miami

Clinicaltrials.gov ID:

NCT00317616

Neals Affiliated?

Yes

Coordinating Center Contact Information

Study Sponsor:

University of Miami

Participant Duration:

Until appearance of manifest disease

Estimated Enrollment:

500

Estimated Study Start Date:

04 / 01 / 2006

Estimated Study Completion Date:

12 / 01 / 2027

Posting Last Modified Date:

03 / 10 / 2023

Date Study Added to neals.org:

04 / 25 / 2006