Study Purpose:
CRiALS is an umbrella protocol through which people are recruited to participate in a range of research studies being conducted by the ALS Research Collaboration (ARC).Study Status:
Recruiting
Disease:
Amyotrophic Lateral Sclerosis
Study Type:
Observational
Type of Intervention:
N/A
Intervention Name:
N/A
Placebo:
N/A
Phase:
N/A
Study Chair(s)/Principal Investigator(s):
Michael Benatar, MD, PhD., University of Miami
Clinicaltrials.gov ID:
Neals Affiliated?
No
Coordinating Center Contact Information
University of Miami Miller School of Medicine
Anne-Laure Grignon, MD / email hidden; JavaScript is required / 888-413-9315
1120 NW 14 Street, STE 1312
Miami, Florida, 33136 United States
Full Study Summary:
Research goals include elucidation of the complex relationship between ALS and related neurodegenerative disorders, development of both wet and dry biomarkers of disease, and delineation of the full course of the natural history of disease from the early pre-symptomatic stages through established and even late-stage disease. These goals are accomplished through the recruitment and evaluation of patients with ALS and related diseases, family members (including people at genetic risk for ALS, but who are not yet affected), and healthy controls.
Study Sponsor:
University of Miami
Estimated Enrollment:
10000
Estimated Study Start Date:
02 / 01 / 2005
Estimated Study Completion Date:
12 / 01 / 2027
Posting Last Modified Date:
03 / 10 / 2023
Date Study Added to neals.org:
08 / 29 / 2005
Minimum Age:
18 Years
Maximum Age:
N/A
Inclusion Criteria:1. At least 18 years of age.
2. Member of at least one of the following categories:
1. Individuals affected with ALS or a related neurodegenerative disease (sporadic or familial)
2. Unaffected individuals from fALS pedigrees, including pre-symptomatic individuals at genetic risk for ALS or individuals from pedigrees of ALS related diseases.
3. Healthy controls
3. Able and willing to comply with relevant procedures.
Exclusion Criteria:
1. Subject has a condition or is in a situation which, in the PI's opinion, could confound the study finding or may interfere significantly with the individual's participation and compliance with the study protocol -- including but not limited to neurological, psychological and/or medical conditions (e.g., multiple sclerosis, neuropathy, myelopathy).
University of Miami | Recruiting
Anne-Laure Grignon, MD / 888-413-9315 / email hidden; JavaScript is required
Miami, Florida
33136
United States