Clinical Research in Amyotrophic Lateral Sclerosis

Study Purpose:

CRiALS is an umbrella protocol through which people are recruited to participate in a range of research studies being conducted by the ALS Research Collaboration (ARC).

Study Status:



Amyotrophic Lateral Sclerosis

Study Type:


Type of Intervention:


Intervention Name:






Study Chair(s)/Principal Investigator(s):

Michael Benatar, MD, PhD., University of Miami ID:


Neals Affiliated?


Coordinating Center Contact Information

University of Miami Miller School of Medicine

Anne-Laure Grignon, MD / email hidden; JavaScript is required / 888-413-9315

1120 NW 14 Street, STE 1312
Miami, Florida, 33136 United States

Full Study Summary:

Research goals include elucidation of the complex relationship between ALS and related neurodegenerative disorders, development of both wet and dry biomarkers of disease, and delineation of the full course of the natural history of disease from the early pre-symptomatic stages through established and even late-stage disease. These goals are accomplished through the recruitment and evaluation of patients with ALS and related diseases, family members (including people at genetic risk for ALS, but who are not yet affected), and healthy controls.

Study Sponsor:

University of Miami

Estimated Enrollment:


Estimated Study Start Date:

02 / 01 / 2005

Estimated Study Completion Date:

12 / 01 / 2027

Posting Last Modified Date:

03 / 10 / 2023

Date Study Added to

08 / 29 / 2005

Minimum Age:

18 Years

Maximum Age:


Inclusion Criteria:

1. At least 18 years of age.

2. Member of at least one of the following categories:

1. Individuals affected with ALS or a related neurodegenerative disease (sporadic or familial)

2. Unaffected individuals from fALS pedigrees, including pre-symptomatic individuals at genetic risk for ALS or individuals from pedigrees of ALS related diseases.

3. Healthy controls

3. Able and willing to comply with relevant procedures.

Exclusion Criteria:

1. Subject has a condition or is in a situation which, in the PI's opinion, could confound the study finding or may interfere significantly with the individual's participation and compliance with the study protocol -- including but not limited to neurological, psychological and/or medical conditions (e.g., multiple sclerosis, neuropathy, myelopathy).

University of Miami | Recruiting

Anne-Laure Grignon, MD / 888-413-9315 / email hidden; JavaScript is required

Miami, Florida 33136
United States