NEALS Single Institutional Review Board (cIRB)

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Overview of the Single IRB

The single Institutional Review Board (sIRB) for selected NEALS clinical trials is the Mass General Brigham Human Research Committee, located in Boston, MA. It is the same sIRB that oversees all studies conducted by the NeuroNEXT Network ( ( Sites that participate in studies that utilize the NEALS sIRB must have an executed Reliance Agreement (RA) to rely on the Mass General Brigham IRB. Signing the NEALS RA does not preclude a site from participating in any other IRB authorization agreements that it may have or entered with other entities.

If your site is interested in executing a Reliance Agreement with the Mass General Brigham, please contact Alexi Drilea at email hidden; JavaScript is required and/or Melissa Cirino at email hidden; JavaScript is required 

List of Participating NEALS Sites with an Executed Reliance Agreement

Current as of June 2022

  • ALS Center at the Swedish Neuroscience Institute
  • Atrium Health
  • Augusta University
  • Barrow Neurological Institute
  • Beth Israel Deaconess Medical Center
  • Brigham and Women’s Hospital
  • California Pacific Medical Center
  • Cedars-Sinai Medical Center
  • Cleveland Clinic
  • Columbia University Medical Center
  • Dartmouth-Hitchcock
  • Drexel University
  • Duke University Medical Center
  • Emory University
  • Essentia Health
  • George Washington University
  • Georgetown University
  • Hackensack Meridian Health
  • Henry Ford Hospital
  • Holy Cross Hospital
  • Hospital for Special Care
  • Indiana University
  • Jefferson Weinberg ALS Center
  • Johns Hopkins University
  • Kaiser Permanente
  • Lahey Clinic
  • Las Vegas Clinic
  • Lehigh Valley Hospital
  • Loma Linda University
  • Massachusetts General Hospital
  • Mayo Clinic (includes Jacksonville, Phoenix, and Rochester)
  • Medical College of Wisconsin
  • Medical University of South Carolina
  • Methodist Neurological Institute
  • Minneapolis Medical Research Foundation
  • Mount Sinai Beth Israel
  • Neurology Associates
  • Neuromuscular Research Center
  • Northwestern University
  • Nova Southeastern University
  • Ochsner Neuroscience Institute
  • Ohio Health
  • Ohio State University
  • Oregon Health & Science University
  • Penn State University School of Medicine
  • Providence ALS Center, Portland, OR
  • Saint Alphonsus Regional Medical Center
  • Saint Louis University
  • Spectrum Health Medical Group
  • St. Luke’s Rehabilitation Institute
  • SUNY at Stony Brook
  • SUNY Upstate Medical Center
  • Temple University
  • Texas Neurology, P.A.
  • Twin Cities ALS Research Consortium
  • University of Arkansas for Medical Sciences
  • University of California, Davis
  • University of California, Irvine
  • University of California, Los Angeles
  • University of California, San Francisco
  • University of Chicago
  • University of Cincinnati
  • University of Colorado
  • University of Florida, Gainesville
  • University of Florida, Jacksonville
  • University of Iowa
  • University of Kansas Medical Center
  • University of Kentucky
  • University of Maryland
  • University of Massachusetts Medical School
  • University of Miami
  • University of Michigan
  • University of Minnesota
  • University of Missouri
  • University of Nebraska Medical Center
  • University of Pennsylvania
  • University of Pittsburgh
  • University of South Florida
  • University of Southern California
  • University of Texas Health Science Center, San Antonio
  • University of Utah
  • University of Virginia
  • University of Washington
  • Vanderbilt University Medical Center
  • Virginia Commonwealth University
  • Wake Forest University Health Sciences
  • Washington University in St. Louis
  • Wesley Neurology Clinic
  • Yale University

Resources for Sites:


NEALS Central IRB (cIRB) Model Webinar
September 12, 2016
This webinar was presented by the NEALS Central IRB. Covered in this webinar were general comments on central IRBs, a brief overview of the NEALS cIRB model, and a discussion on the NEALS Reliance Agreement.

Watch Here

The pilot initiative was made possible by the generous support of The ALS Association.